kcnmb2
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  • Official Full Name
  • potassium large conductance calcium-activated channel, subfamily M, beta member 2
  • Background
  • MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Two variants encoding the same protein have been found for this gene.
  • Synonyms
  • KCNMB2; potassium large conductance calcium-activated channel, subfamily M, beta member 2; calcium-activated potassium channel subunit beta-2; hbeta2; hbeta3; BKbeta2; hCG1646471; slo-beta-2; k(VCA)beta-2; BK channel subunit beta-2; MaxiK channel beta 2 s
Cat.#:KCNMB2-273HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KCNMB2, His-tagged
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Cat.#:KCNMB2-8539MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KCNMB2 Protein
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Cat.#:KCNMB2-3216RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNMB2 Protein
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Cat.#:KCNMB2-2366RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KCNMB2 Protein, His-tagged
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Cat.#:KCNMB2-2192ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KCNMB2
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Cat.#:KCNMB2-5026HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KCNMB2 293 Cell Lysate
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Cat.#:KCNMB2-5027HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KCNMB2 293 Cell Lysate
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Involved Pathway

KCNMB2 involved in several pathways and played different roles in them. We selected most pathways KCNMB2 participated on our site, such as Ca2+ activated K+ channels, Hemostasis, Insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNMB2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ca2+ activated K+ channels
KCNN1B; KCNMB2; KCNN4; KCNMA1; KCNN1A; KCNN2; KCNMB1; KCNN3; KCNN1
Hemostasis
ITGB3A; GATA1; DGKG; NADL1.1; HBB-Y; F3B; PRTN3; RHOGA; DGKQ; CALU
Insulin secretion
PDX1; PRKCA; FFAR1; GNAS; PLCB4; KCNMA1; PLCB1; VAMP2; PRKACA; PLCB3
Neuronal System
DLG1L; KCNS3; AKAP5; KCNJ1B; GJA10; PANX1; KCNB2; PPFIA4; KCNN4; KCNH1A
Nitric oxide stimulates guanylate cyclase
KCNMB2; KCNMB1; PDE10A; KCNMA1
Platelet homeostasis
KCNMA1; APOER2; KCNMB1; KCNMB2; ATP2B1B; PDE10A; SLC8A2A; ATP2B3A
Potassium Channels
KCNH1; KCNH2A; KCNF1; HCN4; KCNH8; KCNC1B; KCNAB3; KCNJ1A.2; KCNV2; KCNC1
Vascular smooth muscle contraction
PRKG1A; PRKCE; GNA13A; ADCY1B; ROCK2A; GNA11B; GNA15.1; ADRA1BB; CALCRLA; PPP1R14AA

Protein Function

KCNMB2 has several biochemical functions, for example, calcium-activated potassium channel activity, ion channel inhibitor activity, potassium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNMB2 itself. We selected most functions KCNMB2 had, and list some proteins which have the same functions with KCNMB2. You can find most of the proteins on our site.
Function
Related Protein
Function calcium-activated potassium channel activity
Related Protein KCNN4; PKD2L1; KCNMB3; KCNMB4; KCNMB2; KCNN1; KCNMB1; KCNN1B; KCNN1A; HPN
Function ion channel inhibitor activity
Related Protein GNB2L1; KCNV1; KCNMB2; PDZD3; RSC1A1; ENSA; STOML1
Function potassium channel regulator activity
Related Protein KCNIP2; DPP10; KCNIP1; SGK2; DLG1; SGK1; NEDD4L; KCNMB1; KCNE1; KCNMB4

Interacting Protein

KCNMB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNMB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNMB2.
KCNMA1

KCNMB2 Related Articles

Beecham, GW; Hamilton, K; et al. Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias. PLOS GENETICS 10:-(2014).
Wong, AHC; Lipska, BK; et al. Cortical gene expression in the neonatal ventral-hippocampal lesion rat model. SCHIZOPHRENIA RESEARCH 77:261-270(2005).