kdelr3
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  • Official Full Name
  • KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
  • Background
  • Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment.Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae.This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER.In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein.Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described.KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins.Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described.
  • Synonyms
  • KDELR3; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; ER lumen protein retaining receptor 3; KDEL receptor 3; KDEL endoplasmic reticulum protein retention receptor 3; ERD2L3
Cat.#:KDELR3-8584MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KDELR3 Protein
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Cat.#:KDELR3-2167CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KDELR3
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Cat.#:KDELR3-10912ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KDELR3
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Cat.#:KDELR3-4998HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human KDELR3 293 Cell Lysate
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Cat.#:KDELR3-4999HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human KDELR3 293 Cell Lysate
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Involved Pathway

KDELR3 involved in several pathways and played different roles in them. We selected most pathways KDELR3 participated on our site, such as IRE1alpha activates chaperones, Metabolism of proteins, Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with KDELR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
IRE1alpha activates chaperones
ADD1; DNAJB9; HDGF; SERP1; CTDSP2; YIF1A; ASNA1; SEC63; PDIA6; SEC61B
Metabolism of proteins
YKT6; SLC38A8; BCHE; IGFBP6; EXOC6; FBXL5; CPB2; EIF5; GPR119; ADAMTSL4
Unfolded Protein Response (UPR)
SEC63; YY2; WIPI1; TPP1; FKBP14; SERP1; YIF1A; PDIA6; C19orf10; DNAJB9
Vibrio cholerae infection
PLCG1; ATP6V1A; PRKACG; ATP6V0B; ATP6V1G1; ATP6V1E2; ATP6V1B2; ATP6V0C; ACTB; ERO1L
XBP1(S) activates chaperone genes
DNAJB9; CTDSP2; TPP1; C19orf10; WIPI1; HYOU1; KDELR3; DDX11; KLHDC3; SEC63

Protein Function

KDELR3 has several biochemical functions, for example, ER retention sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDELR3 itself. We selected most functions KDELR3 had, and list some proteins which have the same functions with KDELR3. You can find most of the proteins on our site.
Function
Related Protein
Function ER retention sequence binding
Related Protein KDELR3; KCNIP2; KDELR2B; KDELR2A; KIAA1199

KDELR3 Related Articles

Lee, JH; Park, DY; et al. Intracellular Reprogramming of Expression, Glycosylation, and Function of a Plant-Derived Antiviral Therapeutic Monoclonal Antibody. PLOS ONE 8:-(2013).
VILLEVAL, JL; MITJAVILA, MT; et al. AUTOCRINE STIMULATION BY ERYTHROPOIETIN (EPO) REQUIRES EPO SECRETION. BLOOD 84:2649-2662(1994).