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KDELR3

  • Official Full Name

    KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

  • Overview

    Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment.Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae.This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER.In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein.Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described.KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins.Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described.
  • Synonyms

    KDELR3; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; ER lumen protein retaining receptor 3; KDEL receptor 3; KDEL endoplasmic reticulum protein retention receptor 3; ERD2L3;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Danio rerio (Zebrafish) (Brachydanio rerio)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Xenopus laevis (African clawed frog)
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • Zebrafish
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KDELR3-4998HCL Recombinant Human KDELR3 293 Cell Lysate HEK293 N/A
Human KDELR3-4999HCL Recombinant Human KDELR3 293 Cell Lysate HEK293 N/A
Mouse KDELR3-8584M Recombinant Mouse KDELR3 Protein Mammalian Cell His
Mouse KDELR3-4774M Recombinant Mouse KDELR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse KDELR3-4774M-B Recombinant Mouse KDELR3 Protein Pre-coupled Magnetic Beads HEK293
Danio rerio (Zebrafish) (Brachydanio rerio) RFL9072DF Recombinant Full Length Danio Rerio Er Lumen Protein Retaining Receptor 3(Kdelr3) Protein, His-Tagged E.coli expression system His Full Length (1-215)
Homo sapiens (Human) RFL29396HF Recombinant Full Length Human Er Lumen Protein Retaining Receptor 3(Kdelr3) Protein, His-Tagged E.coli expression system His Full Length (1-214)
Mus musculus (Mouse) RFL31749MF Recombinant Full Length Mouse Er Lumen Protein Retaining Receptor 3(Kdelr3) Protein, His-Tagged E.coli expression system His Full Length (1-214)
Xenopus laevis (African clawed frog) RFL9738XF Recombinant Full Length Xenopus Laevis Er Lumen Protein Retaining Receptor 3(Kdelr3) Protein, His-Tagged E.coli expression system His Full Length (1-214)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL23938XF Recombinant Full Length Xenopus Tropicalis Er Lumen Protein Retaining Receptor 3(Kdelr3) Protein, His-Tagged E.coli expression system His Full Length (1-214)
Zebrafish KDELR3-10912Z Recombinant Zebrafish KDELR3 Mammalian Cell His
Chicken KDELR3-2167C Recombinant Chicken KDELR3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KDELR3 Related Articles

KDELR3 involved in several pathways and played different roles in them. We selected most pathways KDELR3 participated on our site, such as IRE1alpha activates chaperones, Metabolism of proteins, Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with KDELR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
IRE1alpha activates chaperonesYIF1A;C19orf10;HYOU1;KDELR3;WIPI1;CTDSP2;PDIA6;KLHDC3;SEC63
Metabolism of proteinsFURINB;HSCB;B3GNT3;MBOAT4;TRAPPC5;NSMCE1;SFTPBB;SCMH1;TRAPPC9
Unfolded Protein Response (UPR)SEC63;PDIA6;KDELR3;CXXC1;YY2;HDGF;DNAJB9;KLHDC3;CTDSP2
Vibrio cholerae infectionATP6V1H;ATP6V0D1;ATP6V1G2;ATP6V0E1;PRKACB;ATP6V1B2;ATP6V1E2;PRKACG;ATP6V1F
XBP1(S) activates chaperone genesCXXC1;DDX11;FKBP14;TPP1;C19orf10;ASNA1;SERP1;DNAJB9;HDGF

KDELR3 has several biochemical functions, for example, ER retention sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDELR3 itself. We selected most functions KDELR3 had, and list some proteins which have the same functions with KDELR3. You can find most of the proteins on our site.

Function Related Protein
ER retention sequence bindingKIAA1199;KDELR2B;KDELR2A;KCNIP2;KDELR3

KDELR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDELR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KDELR3.

Lee, JH; Park, DY; et al. Intracellular Reprogramming of Expression, Glycosylation, and Function of a Plant-Derived Antiviral Therapeutic Monoclonal Antibody. PLOS ONE 8:-(2013).
VILLEVAL, JL; MITJAVILA, MT; et al. AUTOCRINE STIMULATION BY ERYTHROPOIETIN (EPO) REQUIRES EPO SECRETION. BLOOD 84:2649-2662(1994).
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