|Official Full Name||Kruppel-like factor 12|
|Background||Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||KLF12; Kruppel-like factor 12; Krueppel-like factor 12; AP 2 repressor; AP 2rep; AP 2rep transcription factor; AP2REP; HSPC122; KLF12 zinc finger transcriptional repressor; AI315654; AP-2rep; B130052C06Rik; D530033K05Rik; OTTHUMP00000018503; 2700063E05Rik; AI225908; AP-2 repressor; AP-2rep transcription factor; Krueppel like factor 12; Transcriptional repressor AP 2rep; transcriptional repressor AP-2rep|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
KLF12 involved in several pathways and played different roles in them. We selected most pathways KLF12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
KLF12 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF12 itself. We selected most functions KLF12 had, and list some proteins which have the same functions with KLF12. You can find most of the proteins on our site.
|DNA binding||MSL3; TADA2B; HOXC12A; ERCC3; MB21D2; TOP1L; PCBP2; ZFY1; ESR2B; TFDP2|
|RNA polymerase II regulatory region sequence-specific DNA binding||BARX2; RARA; RELA; NKX2-1; TAL2; NFIL3; ZIK1; H2AFY2; SOX13; ESRRG|
|metal ion binding||NRD1B; LHX8A; MTHFS; ERCC2; ZNF143A; ITGA1; TET3; COL5A1; LOXL2A; ZNF335|
|protein binding||ANXA9; FLVCR1; SMARCD3; CDC25A; DIAP1; CST3; C10orf137; CCDC64B; MAPK1; DEDD|
|transcription corepressor activity||PIAS1; NRIP1; LHX1A; PRMT5; BRD7; SKOR1; HIPK2; CDX2; SSX5; RUNX1T1|
|transcription factor activity, sequence-specific DNA binding||HELT; ZNF573; FOXA3; FOXN3; REST; ZNF238; MZF1; VAV1; ZFP354B; NOTCH1|
|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding||MSX2; ZEB1; ZBTB12.2; ETV7; GLIS1; ASCL3; BCL6AB; CHCHD3; ZBTB4; ARHGAP35|
KLF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF12.
CTBP1; THAP1; EHMT2