KLF12 Protein, Kruppel-like factor 12


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Official Full Name Kruppel-like factor 12
Background Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms KLF12; Kruppel-like factor 12; Krueppel-like factor 12; AP 2 repressor; AP 2rep; AP 2rep transcription factor; AP2REP; HSPC122; KLF12 zinc finger transcriptional repressor; AI315654; AP-2rep; B130052C06Rik; D530033K05Rik; OTTHUMP00000018503; 2700063E05Rik; AI225908; AP-2 repressor; AP-2rep transcription factor; Krueppel like factor 12; Transcriptional repressor AP 2rep; transcriptional repressor AP-2rep
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KLF12-602H Recombinant Human Kruppel-like factor 12, His-tagged E.coli His
    Mouse KLF12-8676M Recombinant Mouse KLF12 Protein Mammalian Cell His
    Rhesus Macaque KLF12-2413R Recombinant Rhesus monkey KLF12 Protein, His-tagged Mammalian Cell His

    KLF12 involved in several pathways and played different roles in them. We selected most pathways KLF12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    KLF12 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF12 itself. We selected most functions KLF12 had, and list some proteins which have the same functions with KLF12. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding MSL3; TADA2B; HOXC12A; ERCC3; MB21D2; TOP1L; PCBP2; ZFY1; ESR2B; TFDP2
    RNA polymerase II regulatory region sequence-specific DNA binding BARX2; RARA; RELA; NKX2-1; TAL2; NFIL3; ZIK1; H2AFY2; SOX13; ESRRG
    metal ion binding NRD1B; LHX8A; MTHFS; ERCC2; ZNF143A; ITGA1; TET3; COL5A1; LOXL2A; ZNF335
    protein binding ANXA9; FLVCR1; SMARCD3; CDC25A; DIAP1; CST3; C10orf137; CCDC64B; MAPK1; DEDD
    transcription corepressor activity PIAS1; NRIP1; LHX1A; PRMT5; BRD7; SKOR1; HIPK2; CDX2; SSX5; RUNX1T1
    transcription factor activity, sequence-specific DNA binding HELT; ZNF573; FOXA3; FOXN3; REST; ZNF238; MZF1; VAV1; ZFP354B; NOTCH1
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding MSX2; ZEB1; ZBTB12.2; ETV7; GLIS1; ASCL3; BCL6AB; CHCHD3; ZBTB4; ARHGAP35

    KLF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF12.


    Pentheroudakis, G; Kotoula, V; et al. A study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: a translational research study of the Hellenic Cooperative Oncology Group (HeCOG). BMC CANCER 14:-(2014).

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