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LATS1

Official Full Name

LATS, large tumor suppressor, homolog 1
Overview

LATS1 (Large tumor suppressor 1) is a putative serine/threonine kinase that belongs to the NDR family. It is a tumor suppressor that plays a critical role in the maintenance of ploidy. LATS1 localizes to the centrosome and the mitotic spindle and controls
Synonyms

LATS1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS (large tumor suppressor, Drosophila) homolog 1; serine/threonine-protein kinase LATS1; WARTS; h-warts; WARTS protein kinase; large tumor suppressor homolog 1; wts;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

HEK293
Mammalian Cell
Sf9 Insect Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LATS1-1423H	Active Recombinant Human LATS1, GST-tagged	Sf9 Insect Cell	GST	589 aa-end	Inquiry
Human	LATS1-974HCL	Recombinant Human LATS1 cell lysate		N/A		Inquiry
Mouse	LATS1-8971M	Recombinant Mouse LATS1 Protein	Mammalian Cell	His		Inquiry
Mouse	LATS1-5003M	Recombinant Mouse LATS1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	LATS1-5003M-B	Recombinant Mouse LATS1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	LATS1-2707Z	Recombinant Zebrafish LATS1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
LATS1 Related Articles

LATS1 involved in several pathways and played different roles in them. We selected most pathways LATS1 participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LATS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hippo signaling pathway	SNAI2;YWHAH;NKD1;PPP2R2D;FRMD6;CCND3;PPP2R1A;WTIP;MOBKL1A

LATS1 has several biochemical functions, for example, ATP binding, magnesium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LATS1 itself. We selected most functions LATS1 had, and list some proteins which have the same functions with LATS1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	MAP4K2;PANK1;MAPKAPK5;GCLC;MARS2;XRCC5;PPP1CA;MLKL;NUBP2
magnesium ion binding	ABL1;PRKACB;INPP1;THTPA;RPS6KAL;FARSB;STK3;NUDT18;FAN1
protein binding	DNAJB11;CTF1;ARL4A;DUSP19;NUPL1;TCEANC2;LRRK2;INCENP;HOMER3
protein kinase binding	SV2A;SOCS1;RHOD;CASP9;CADPS;STX1B;AKAP7;GRB2;CCNA2
protein serine/threonine kinase activity	GRK7B;ACVR1B;ULK4;SLC14A2;STK39;BMPR1AA;PRKCB;PRKACAA;STK30

LATS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LATS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LATS1.

YAP1; MOB1B; MOB1A

Meistermann, H; Gao, JJ; et al. A Novel Immuno-Competitive Capture Mass Spectrometry Strategy for Protein-Protein Interaction Profiling Reveals That LATS Kinases Regulate HCV Replication Through NS5A Phosphorylation. MOLECULAR & CELLULAR PROTEOMICS 13:3040-3048(2014).

Chan, SW; Lim, CJ; et al. Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 288:37296-37307(2013).