lats1
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  • Official Full Name
  • LATS, large tumor suppressor, homolog 1
  • Background
  • LATS1 (Large tumor suppressor 1) is a putative serine/threonine kinase that belongs to the NDR family. It is a tumor suppressor that plays a critical role in the maintenance of ploidy. LATS1 localizes to the centrosome and the mitotic spindle and controls
  • Synonyms
  • LATS1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS (large tumor suppressor, Drosophila) homolog 1; serine/threonine-protein kinase LATS1; WARTS; h-warts; WARTS protein kinase; large tumor suppressor homolog 1; wts
Cat.#:LATS1-8971MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LATS1 Protein
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Cat.#:LATS1-2707ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LATS1
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Cat.#:LATS1-1423HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human LATS1 (Active), GST-tagged
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Cat.#:LATS1-974HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LATS1 cell lysate
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Involved Pathway

LATS1 involved in several pathways and played different roles in them. We selected most pathways LATS1 participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LATS1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hippo signaling pathway
PPP2R1B; PRKCZ; WNT3; APC; BIRC2; TEAD3; GSK3B; WNT8A; TGFBR1; BMP4

Protein Function

LATS1 has several biochemical functions, for example, ATP binding, magnesium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LATS1 itself. We selected most functions LATS1 had, and list some proteins which have the same functions with LATS1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CKMA; TUT1; HSP90AA1.2; PIK3CD; TNIK; POMK; MAPK8B; MCM4; NAT1; JAK1
Function magnesium ion binding
Related Protein PSPH; ILVBL; ALPP; RPS6KA3; IMPA1; ENO1; STK36; RPS6KA6; EYA2; PKM2
Function protein binding
Related Protein C9orf100; DCUN1D4; ABLIM3; TSPAN15; FAM109A; STX4; RBFOX2; Aatk; RTN4A; CD200R3
Function protein kinase binding
Related Protein SPDYE2; GATA4; CLTC; AP2A1; PTPN23; HSPB1; APC; KIF20A; CAMK2N1; CD4
Function protein serine/threonine kinase activity
Related Protein MAPK4; PAK2; GM4922; SRPK1A; CAMK2A; ALPK2; STK39; TTN; MAP3K12; DSTYK

Interacting Protein

LATS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LATS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LATS1.
YAP1; MOB1B; MOB1A

LATS1 Related Articles

Meistermann, H; Gao, JJ; et al. A Novel Immuno-Competitive Capture Mass Spectrometry Strategy for Protein-Protein Interaction Profiling Reveals That LATS Kinases Regulate HCV Replication Through NS5A Phosphorylation. MOLECULAR & CELLULAR PROTEOMICS 13:3040-3048(2014).
Chan, SW; Lim, CJ; et al. Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 288:37296-37307(2013).