LATS1

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LATS1

Official Full Name LATS, large tumor suppressor, homolog 1
Background LATS1 (Large tumor suppressor 1) is a putative serine/threonine kinase that belongs to the NDR family. It is a tumor suppressor that plays a critical role in the maintenance of ploidy. LATS1 localizes to the centrosome and the mitotic spindle and controls
Synonyms LATS1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS (large tumor suppressor, Drosophila) homolog 1; serine/threonine-protein kinase LATS1; WARTS; h-warts; WARTS protein kinase; large tumor suppressor homolog 1; wts
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LATS1-1423H Recombinant Human LATS1 (Active), GST-tagged Sf9 Insect Cell GST
    Human LATS1-974HCL Recombinant Human LATS1 cell lysate N/A
    Mouse LATS1-8971M Recombinant Mouse LATS1 Protein Mammalian Cell His
    Zebrafish LATS1-2707Z Recombinant Zebrafish LATS1 Mammalian Cell His

    LATS1 involved in several pathways and played different roles in them. We selected most pathways LATS1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with LATS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hippo signaling pathway GDF5; WWC1; DVL3; NF2; YAP1; FZD3; WNT6; SAV1; FZD1; WNT5A

    LATS1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by LATS1 itself. We selected most functions LATS1 had, and list some proteins which have the same functions with LATS1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding NRBP2; KCNJ11; NMNAT1; ACVR2AA; STK32B; EPHB3; ADCK3; WARS; MVD; CENPE
    magnesium ion binding TSSK4; CIB4; ADPRH; HPGDS; ATP10A; PGM3; CIB3; FOXK2; IRAK3; OPA1
    protein binding KIT; CLCNKB; COL1A2; NAT8B; CALM3; VDAC2; SUV39H1; LRCH3; EFCAB11; GLI2
    protein kinase binding FAM83A; CENPJ; CDKN2B; USP37; MAVS; EEF2; PRKAG2; CAV1; KIF11; CADPS
    protein serine/threonine kinase activity DCLK3; MAP3K11; BMPR1AB; CAMK1DA; STRC; SRPK1B; CLK3; MAP3K14; MAPK4; SRPK1A

    LATS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LATS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LATS1.

    YAP1; MOB1B; MOB1A

    Meistermann, H; Gao, JJ; et al. A Novel Immuno-Competitive Capture Mass Spectrometry Strategy for Protein-Protein Interaction Profiling Reveals That LATS Kinases Regulate HCV Replication Through NS5A Phosphorylation. MOLECULAR & CELLULAR PROTEOMICS 13:3040-3048(2014).
    Chan, SW; Lim, CJ; et al. Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 288:37296-37307(2013).

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