lats2
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  • Official Full Name
  • large tumor suppressor kinase 2
  • Background
  • This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
  • Synonyms
  • LATS2; large tumor suppressor kinase 2; KPM; serine/threonine-protein kinase LATS2; warts-like kinase; serine/threonine kinase KPM; large tumor suppressor homolog 2; serine/threonine-protein kinase kpm; LATS, large tumor suppressor, homolog 2; kinase phosphorylated during mitosis protein; LATS (large tumor suppressor, Drosophila) homolog 2;
Cat.#:LATS2-28502THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human LATS2
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Cat.#:LATS2-381HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human LATS2, GST-tagged
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Cat.#:LATS2-6686ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LATS2
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Cat.#:LATS2-6821ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LATS2
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Cat.#:LATS2-1541HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human LATS2, Unactive, GST-tagged
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Cat.#:LATS2-4813HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human LATS2 293 Cell Lysate
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Involved Pathway

LATS2 involved in several pathways and played different roles in them. We selected most pathways LATS2 participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LATS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hippo signaling pathway
STK3; WNT10B; APC2; SMAD4; BMP6; MPP5; TEAD2; BMPR1A; WNT11; LLGL2

Protein Function

LATS2 has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LATS2 itself. We selected most functions LATS2 had, and list some proteins which have the same functions with LATS2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein Abca2; DAPK1; NMNAT3; TEX14; CDC42BPG; ATP12A; ATP1A1B; RECQL5; ATP5B; TWF2
Function metal ion binding
Related Protein ZNF256; ZFP410; ZNF831; ITGA5; LMX1BB; MFNG; CYP51; ACSM5; WT1A; BMPR1A
Function protein binding
Related Protein FKBPL; NCOA1; CSRP2; ZNF423; RABGEF1; MAPRE2; OXR1; SYK; BTG3; RGS19
Function protein serine/threonine kinase activity
Related Protein CSNK1E; PRKCBB; CLK1; ADCK4; TNIK; ACVR2B; MTOR; NUAK2; BMPR1A; MAP4K3

Interacting Protein

LATS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LATS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LATS2.
MOB1A; MOB1B; AJUBA; VPRBP; SNAI1; UBI1; LATS1; LMNA

LATS2 Related Articles

Meistermann, H; Gao, JJ; et al. A Novel Immuno-Competitive Capture Mass Spectrometry Strategy for Protein-Protein Interaction Profiling Reveals That LATS Kinases Regulate HCV Replication Through NS5A Phosphorylation. MOLECULAR & CELLULAR PROTEOMICS 13:3040-3048(2014).
Chan, SW; Lim, CJ; et al. Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 288:37296-37307(2013).