LCK

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LCK

Official Full Name lymphocyte-specific protein tyrosine kinase
Background Lck is a 56 kD tyrosine protein kinase and a member of the src subfamily that contains both an SH2 and SH3 domain. Alternatively spliced isoforms of Lck have been reported. Lck is a cytoplasmic protein bound to CD4 and CD8 in T lymphocytes that participat
Synonyms LCK; lymphocyte-specific protein tyrosine kinase; tyrosine-protein kinase Lck; leukocyte C-terminal Src kinase; p56(LSTRA) protein-tyrosine kinase; t cell-specific protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; lymphocyte cell-specif
    • Type:
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LCK-1424H Recombinant Human LCK (Active), GST-tagged Sf9 Insect Cell GST
    Human LCK-16H Recombinant Human LCK, His-tagged E.coli His
    Human LCK-173H Recombinant Human LCK E.coli N/A
    Human LCK-174H Recombinant Human LCK, SH3 Domain, GST-tagged E.coli GST
    Human LCK-273H Recombinant Human LCK, MYC/DDK-tagged HEK293 Myc/DDK
    Human LCK-29218TH Recombinant Human LCK E.coli N/A
    Human LCK-29937TH Recombinant Human LCK N/A
    Human LCK-342H Recombinant Human LCK, GST-tagged, Active Sf9 Insect Cell GST
    Human LCK-573H Recombinant Human LCK, GST-tagged Sf9 Insect Cell GST
    Human LCK-60H Recombinant Human LCK protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human LCK-681HCL Recombinant Human LCK cell lysate Insect Cell N/A
    Human LCK-692H Recombinant Human LCK, His-tagged S.frugiperda His
    Human LCK-776H Recombinant Human LCK, GST tagged Insect Cell GST
    Rat LCK-3365R Recombinant Rat LCK Protein Mammalian Cell His
    Zebrafish LCK-220Z Recombinant Zebrafish LCK Mammalian Cell His
    Kit-0508 p56Lck Kinase (Human) Assay/Inhibitor Screening Assay Kit N/A

    LCK involved in several pathways and played different roles in them. We selected most pathways LCK participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with LCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway LTB; GM13304; XIAP; LYN; BCL10; CCL21; UBE2I; LTA; TNFSF13B; GM10591
    Osteoclast differentiation MAPK1; PIK3CG; SOCS1; TYK2; LILRB2; ITGB3; PIK3CA; FOS; PPP3R2; IFNAR1
    Natural killer cell mediated cytotoxicity FAS; CD48; PPP3CB; IFNA4; PTPN6; HLA-C; MAP2K2; IFNA8; SHC2; VAV1
    T cell receptor signaling pathway GRB2; BCL10; MAPK3; AKT2; PIK3R1; CD247; PIK3CD; MAPK11; SLA1; IKBKB
    HTLV-I infection AKT2; PRKACA; SLC25A31; ANAPC2; H2-Q10; PPP3CB; MAP3K3; ATM; HLA-DQA1; PDGFRA
    Primary i CD8B1; CD8A; CD4; AICDA; CD3D; UNG; PTPRC; ORAI1; TAP1; LCK
    nodeficiency LCK; ZAP70; Cd79a, Cd79b; AIRE; TAP2; CD40; DCLRE1C; CD8B; CD4; CD19

    LCK has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by LCK itself. We selected most functions LCK had, and list some proteins which have the same functions with LCK. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding BLM; CDC34A; MST1R; MET; DAPK2; DYNC2H1; SIK2; ACTB; ACOT12; DDX24
    ATPase binding ATP1B3; ESR1; ATP1B1; FXYD3; EZR; SVIP; NR1H2; TAF9; BBC3; ATP6V0A1
    CD4 receptor binding LCK; SPG21; PLSCR4; FYN; PLSCR1
    CD8 receptor binding FYN; LCK
    SH2 domain binding SHCBP1; SIT1; INPPL1; DAG1; JAK2; PAG1; CRK; SH3PXD2B; NUP62; MS4A2
    antigen binding MHC1UKA; IGLC2; IGHM; FCN3; LCK; IL7R; PPP2R1A; LILRA2; HNRNPM; IGKV1-5
    glycoprotein binding Serpina1c; VWF; BBC3; CD4; PTBP3; FYN; RGMA; LDLR; DNAJA2; Serpina1b
    identical protein binding S100A1; SKP2; CALHM1; CEACAM16; SDK2; TRIM39; SP100; SH3GLB1; SIAH1A; SIRT1
    non-membrane spanning protein tyrosine kinase activity PTK2; TXK; SYK; PKDCC; ZAP70; SRC; SRMS; FYNA; ABL1; FES
    phosphatidylinositol 3-kinase binding INSR; DAB1; IRS2; CALM3; INSRB; TYRO3; INSRA; CALM1; INSRR; PDGFRB
    protein C-terminus binding CALCOCO1; HAND2; FIGN; DYNLL1; XRCC5; DST; EFHC1; PRKAA1; LCK; TNNI3K
    protein binding TNS1; PDZK1; ZNF473; MAGEA9; KIF2A; ITGA2; RNF182; CSF2; RBM39; CD163
    protein complex binding CCND1; STK11; NDUFA8; KHDRBS1; CAPG; PDCL; PCSK2; DAG1; PDX1; LAMB3
    protein kinase binding PAK2; TRAP1; MAG; TRAF6; ZC3HC1; MAP2K3; RICTOR; CALM3; PTPN6; FER
    protein phosphatase binding HSF4; GRB2; KAT2A; KCNN4; CDC27; PPP1R3C; TRAF3; RPA2; ANAPC5; CDH5
    protein serine/threonine phosphatase activity PDP1; PPM1BA; ILKAP; PPM1H; PPM1BB; DULLARD; PPM1N; PPM1DB; PPP6C; CDC14C
    protein tyrosine kinase activity TEK; JAK2; CLK4; EPHA4A; CAMKK2; SYK; HCK; CSF1RA; FES; FYNB

    LCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LCK here. Most of them are supplied by our site. Hope this information will be useful for your research of LCK.

    PTPRC; KHDRBS1; tip_shv2c

    Guo, N; Zhang, K; et al. CD147 and CD98 complex-mediated homotypic aggregation attenuates the CypA-induced chemotactic effect on Jurkat T cells. MOLECULAR IMMUNOLOGY 63:253-263(2015).
    Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).

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