lck
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  • Official Full Name
  • lymphocyte-specific protein tyrosine kinase
  • Background
  • Lck is a 56 kD tyrosine protein kinase and a member of the src subfamily that contains both an SH2 and SH3 domain. Alternatively spliced isoforms of Lck have been reported. Lck is a cytoplasmic protein bound to CD4 and CD8 in T lymphocytes that participat
  • Synonyms
  • LCK; lymphocyte-specific protein tyrosine kinase; tyrosine-protein kinase Lck; leukocyte C-terminal Src kinase; p56(LSTRA) protein-tyrosine kinase; t cell-specific protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; lymphocyte cell-specif
Cat.#:LCK-16HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LCK, His-tagged
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Cat.#:LCK-173HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LCK
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Cat.#:LCK-273HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human LCK, MYC/DDK-tagged
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Cat.#:LCK-29218THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LCK
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Cat.#:LCK-29937THTag:
Source (Host):Species:Human
Product nameRecombinant Human LCK
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Cat.#:LCK-573HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human LCK, GST-tagged
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Cat.#:LCK-60HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LCK protein, Flag-tagged, Biotinylated
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Cat.#:LCK-776HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human LCK, GST tagged
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Cat.#:LCK-3365RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LCK Protein
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Cat.#:LCK-220ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LCK
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Cat.#:LCK-174HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LCK, SH3 Domain, GST-tagged
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Cat.#:LCK-342HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human LCK, GST-tagged, Active
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Cat.#:LCK-692HTag:His
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human LCK, His-tagged
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Cat.#:LCK-1424HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human LCK (Active), GST-tagged
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Cat.#:LCK-681HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human LCK cell lysate
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Cat.#:Kit-0508Tag:
Source (Host):Species:
Product namep56Lck Kinase (Human) Assay/Inhibitor Screening Assay Kit
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Involved Pathway

LCK involved in several pathways and played different roles in them. We selected most pathways LCK participated on our site, such as NF-kappa B signaling pathway, Osteoclast differentiation, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with LCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
LAT; NFKB1; UBE2I; GM13304; CCL21B; IL1R1; DDX58; VCAM1; BIRC3; ICAM1
Osteoclast differentiation
RELB; PLCG2; IFNAR1; LILRB2; SIRPA; STAT1; LILRA2; FOS; MAPK13; CYBB
Natural killer cell mediated cytotoxicity
IFNAR1; PIK3R2; HRAS; VAV2; SHC2; SHC1; PRKCA; NCR3; Raet1a; Casp3
T cell receptor signaling pathway
CD8A; BCL10; SOS1; PPP3CB; CDC42; CD4; NFKBIA; Il2; PIK3R2; IKBKG
HTLV-I infection
IL15RA; MSX2; IL2RB; CRTC1; MAP3K14; HLA-DQA1; IL1R1; CDC16; PPP3R1; ATM
Primary i
ICOS; IL2RG; RFXAP; DCLRE1C; PTPRC; AICDA; IKBKG; AIRE; ZAP70; CD79A
nodeficiency
PTPRC; UNG; CD40; BLNK; RFX5; RFXANK; CD8A; IKBKG; ORAI1; IGLL1

Protein Function

LCK has several biochemical functions, for example, ATP binding, ATPase binding, CD4 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LCK itself. We selected most functions LCK had, and list some proteins which have the same functions with LCK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein EPHA1; UBE2Q1; TCP1; GLULC; ATP10A; DDX21; ATP2B1B; DYRK1A; YME1L1B; PDK1
Function ATPase binding
Related Protein ATP6V1G3; TCIRG1; CAV1; NKAIN1; SNX10; USP25; FXYD3; SLC26A9; WFS1; CHRNA7
Function CD4 receptor binding
Related Protein FYN; PLSCR4; SPG21; LCK; PLSCR1
Function CD8 receptor binding
Related Protein FYN; LCK
Function SH2 domain binding
Related Protein SRC; LILRB1; PTK2; SIT1; DLC1; NUP62; LAX1; SYNGR3; DAG1; ARHGAP5
Function antigen binding
Related Protein LAG3; IGKV1-5; IGJ; SLAMF1; IGLL1; HNRNPM; Ighg; LILRA1; CD40; TOPORS
Function glycoprotein binding
Related Protein THBS1; IDE; LCK; DNAJC5; FBXO6; LDLR; Itgam&Itgb2; ACE2; CNTN1; Serpina1b
Function identical protein binding
Related Protein EID3; PIK3AP1; SOX10; THG1L; ROBO1; VPS41; Serpina1c; DRG1; CIDEB; ZDHHC17
Function non-membrane spanning protein tyrosine kinase activity
Related Protein HCK; ABL1; ZNF143B; JAK3; MELK; FYNB; FGR; PTK2AA; PTK2BB; STYK1
Function phosphatidylinositol 3-kinase binding
Related Protein CALM2; INSRR; CALM1; CALM3; INSR; IGF1RB; IRS2; PDGFRB; IRS1; FLT3
Function protein C-terminus binding
Related Protein MYO1C; LIG4; TBL1X; PEX5; ECM1; VGLL1; ATF4; PHB; PXK; BLOC1S2A
Function protein binding
Related Protein MSH5; HEATR5B; WRNIP1; BAZ1B; PML; NMU; MKL1; NBR1; PALB2; CIC
Function protein complex binding
Related Protein UGT1A6A; PFKP; UQCRFS1; TRAF2; TMED10; STRN; TULP2; KCTD5; PAFAH1B1; UFD1L
Function protein kinase binding
Related Protein DOK7; DUSP3; MAPKAP1; TRIM5; NCS1; BCL2L1; PGAM1; PRKAB1; RELA; TRPV4
Function protein phosphatase binding
Related Protein RPA2; ANAPC5; JAK1; ANAPC7; ROS1; JUP; ERBB2; DRD1; STAT3; PARD3
Function protein serine/threonine phosphatase activity
Related Protein PPM1H; DUSP23; PPM1LB; PPP3CA; PPA2; CDC14B; DULLARD; PPM1AA; CDC14C; PPP6C
Function protein tyrosine kinase activity
Related Protein SRMS; MAP3K9; TNK2; EPHA4A; FGFR1A; PDGFRB; IGF1R; HCK; TYK2; ZNF143B

Interacting Protein

LCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LCK here. Most of them are supplied by our site. Hope this information will be useful for your research of LCK.
PTPRC; KHDRBS1; tip_shv2c

LCK Related Articles

Guo, N; Zhang, K; et al. CD147 and CD98 complex-mediated homotypic aggregation attenuates the CypA-induced chemotactic effect on Jurkat T cells. MOLECULAR IMMUNOLOGY 63:253-263(2015).
Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).