lyn
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  • Official Full Name
  • v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
  • Background
  • Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells. Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396 (equivale
  • Synonyms
  • LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; tyrosine-protein kinase Lyn; JTK8; lck/Yes-related novel protein tyrosine kinase; p53Lyn; p56Lyn; FLJ26625
Cat.#:LYN-1343HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human LYN Protein, MYC/DDK-tagged
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Cat.#:LYN-4556HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LYN Protein, GST-tagged
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Cat.#:LYN-4557HTag:GST/His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LYN Protein, GST/His-tagged
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Cat.#:LYN-514HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LYN Protein, His-tagged
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Cat.#:LYN-252HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human LYN Protein, GST-tagged
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Cat.#:LYN-27984THTag:
Source (Host):Species:Human
Product nameRecombinant Human LYN
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Cat.#:LYN-28760THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LYN
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Cat.#:LYN-61HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LYN protein, Flag-tagged, Biotinylated
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Cat.#:LYN-643HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LYN, GST-tagged
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Cat.#:LYN-7218HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LYN, His-tagged
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Cat.#:LYN-9386MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LYN Protein
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Cat.#:LYN-3514RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LYN Protein
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Cat.#:LYN-1532CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LYN
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Cat.#:LYN-1267ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LYN
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Cat.#:LYN-1127HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, GST-tagged
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Cat.#:LYN-1254HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, His-tagged
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Cat.#:LYN-656HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human LYN cell lysate
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Involved Pathway

LYN involved in several pathways and played different roles in them. We selected most pathways LYN participated on our site, such as Chemokine signaling pathway, NF-kappa B signaling pathway, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
SHC1; CCL4L2; BRAF; CCL19; SHC4; PF4V1; FOXO3; GNG7; GSK3B; CXCL3
NF-kappa B signaling pathway
GM13304; PRKCB; IRAK1; TAB2; NFKB1; PLAU; MAP3K7IP3; LCK; TICAM2; NFKB2
Platelet activation
VWF; FCER1G; MYL12A; PLA2G4C; VASP; GNAQ; GNAS; F2R; ACTG1; TBXAS1
B cell receptor signaling pathway
CD72; PTPN6; PIK3R5; DOK3; LYN; RAF1; CDK4; RAC3; SLA2; RASGRP3
Fc epsilon RI signaling pathway
PDPK1; PIK3R2; GAB2; MAPK13; SYK; PIK3CD; GRB2; GM-CSF; MAPK12; PLCG1
Fc gamma R-mediated phagocytosis
MARCKSL1; WASL; ARPC5L; PLA2G4F; MAPK1; LAT; VAV3; PRKCG; PIK3R2; NCF1
Long-term depression
PLA2G4D; GNA11; KRAS; GNAI3; PPP2R1B; PLA2G4F; GNA12; ITPR3; PRKG2; MAP2K1
Epithelial cell signaling in Helicobacter pylori infection
ATP6V0C; IKBKB; ATP6V1H; ATP6V1G1; ADAM17; ATP6V1G2; MET; MAPK10; TJP1; MAPK11
Epstein-Barr virus infection
RBPJL; MAPK13; POLR2I; CD38; CD19; HLA-G; MAP2K6; SPN; POLR2G; HLA-DQA1
Viral carcinogenesis
TRAF1; PXN; CREB3L1; HIST1H2BO; KRAS; LYN; CCNA1; MRPS18B; HIST2H4A; GTF2A1

Protein Function

LYN has several biochemical functions, for example, ATP binding, SH3 domain binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LYN itself. We selected most functions LYN had, and list some proteins which have the same functions with LYN. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DYRK1B; MTHFD1; HK1; NLRP1; PEX1; PDK1; RIOK2; ABCB7; MYO3B; PLK5
Function SH3 domain binding
Related Protein EVLB; ZFP106; INPP5D; REPS1; MYPN; SH3BP5; ADAM19; ADAM12; DOCK1; ELMO2
Function enzyme binding
Related Protein TUT1; PPARG; MAPK8; ACAT1; UGT1A6B; NOP14; MSH3; YWHAH; EHHADH; JUN
Function gamma-tubulin binding
Related Protein CEP57; NME2; RAB11FIP5; NDRG1; TUBGCP2; TUBGCP4; TUBGCP5; B9D2; TUBGCP3; BLOC1S2A
Function glycosphingolipid binding
Related Protein Il2; LAMB1; SELL; LAMA1; SELP; Cel; LAMC1; LYN
Function integrin binding
Related Protein THBS4; PPAP2B; TNN; IGF1; SFRP2; CALR; EMP2; ECM2; ICAM3; ADAMTS13
Function ion channel binding
Related Protein FHL1; KCNH1; KCNQ1; KCNC1; PDE4B; SRI; EPN1; CAV3; FGF13; KCNB1
Function non-membrane spanning protein tyrosine kinase activity
Related Protein STYK1; EIF2AK2; ZNF143B; JAK2; FES; PKDCC; TXK; JAK3; HCK; FER
Function phosphoprotein binding
Related Protein PRKCSH; YWHAE; YWHAB; RRAGA; RB1; SNCA; DPYSL3; TOX3; SAG; PAFAH1B1
Function platelet-derived growth factor receptor binding
Related Protein PDGFA; TYMP; PTPRJ; PDGFB; Pdgfa&Pdgfb; ITGA5; LYN; PTEN; PDGFRA; FIGF
Function protein binding
Related Protein TBKBP1; DSCAM; MEF2D; Aatk; PTPRJ; RANBP2; C14orf169; SAC3D1; ZMAT2; NPRL2
Function protein tyrosine kinase activity
Related Protein EGFR; CLK4; TYK2; KITA; DYRK3; KITB; ALK; LCK; INSRB; CSF1RA
Function receptor binding
Related Protein CRAT; CNTFR; IDH1; Fgf15; CADM1; Itga10&Itgb1; TNFSF4; REN; ECH1; PTK2B
Function receptor signaling protein tyrosine kinase activity
Related Protein KITB; TYRO3; INSR; EGFR; ERBB4A; KIT; SYK; ERBB2; ERBB3B; EGFRA
Function ubiquitin protein ligase binding
Related Protein UBE2G1A; UBE2T; TP53; RAD18; C10orf46; TXNIP; AXIN1; UBE2V2; CCDC50; FBXW7

Interacting Protein

LYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LYN here. Most of them are supplied by our site. Hope this information will be useful for your research of LYN.
EGFR; polg_hcvh; polg_hcvco; KHDRBS1; polg_hcvj4; PTK2; tip_shv2c

LYN Related Articles

Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
Xiao, ZG; Sperl, B; et al. Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status. ONCOTARGET 5:12877-12890(2014).