lyn
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  • Official Full Name
  • v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
  • Background
  • Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells. Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396 (equivale
  • Synonyms
  • LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; tyrosine-protein kinase Lyn; JTK8; lck/Yes-related novel protein tyrosine kinase; p53Lyn; p56Lyn; FLJ26625
Cat.#:LYNA-760HTag:His&GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LYNA Protein, His/GST-tagged
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Cat.#:LYN-1343HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human LYN Protein, MYC/DDK-tagged
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Cat.#:LYN-4556HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LYN Protein, GST-tagged
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Cat.#:LYN-4557HTag:GST|His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LYN Protein, GST/His-tagged
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Cat.#:LYN-514HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LYN Protein, His-tagged
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Cat.#:LYN-252HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human LYN Protein, GST-tagged
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Cat.#:LYN-27984THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human LYN
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Cat.#:LYN-28760THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LYN
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Cat.#:LYN-61HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human LYN protein, Flag-tagged, Biotinylated
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Cat.#:LYN-643HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LYN, GST-tagged
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Cat.#:LYN-7218HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LYN, His-tagged
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Cat.#:LYN-9386MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LYN Protein
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Cat.#:LYN-3514RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LYN Protein
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Cat.#:LYN-1532CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LYN
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Cat.#:LYN-1267ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LYN
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Cat.#:LYN-1127HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, GST-tagged
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Cat.#:LYN-1254HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, His-tagged
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Cat.#:LYN-656HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human LYN cell lysate
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Involved Pathway

LYN involved in several pathways and played different roles in them. We selected most pathways LYN participated on our site, such as Chemokine signaling pathway, NF-kappa B signaling pathway, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
ARRB2; ROCK2; STAT1; JAK2; CCL3L3; GNGT1; GRK7; CCL18; IKBKG; CCL11
NF-kappa B signaling pathway
TNFSF11; GM13304; CARD11; RELB; CD40LG; Bcl2a1b; TNFSF13B; CXCL2; BTK; NFKBIA
Platelet activation
PPP1CC; ACTB; MAPK3; PRKACG; TBXAS1; PRKACB; ARHGEF1; P2RX1; PRKCI; PRKCZ
B cell receptor signaling pathway
PIK3CD; FCGR2B; NFATC2; ARPC4; ARPC5; MAPK1; ARPC2; BCL2L11; MAPK3; NFATC3
Fc epsilon RI signaling pathway
NRAS; PIK3CD; LYN; PIK3CA; SOS1; MAP2K2; RAF1; MS4A2; BTK; MAP2K1
Fc gamma R-mediated phagocytosis
DOCK2; ARPC5L; VAV2; CDC42; PRKCG; FCGR2B; PLA2G6; WASF2; RAC2; PPAP2C
Long-term depression
PPP2R1B; GRM1; GNAQ; PRKCB; IGF1R; PPP1R17; GNAZ; PRKCG; PLA2G4F; GRID2
Epithelial cell signaling in Helicobacter pylori infection
NFKBIA; JAM2; MAPK13; ATP6V1G2; ADAM17; MAPK11; ATP6V1F; LYN; ATP6V1C2; MAPK10
Epstein-Barr virus infection
IRF3; PTMA; CSNK2A2; IL10RB; MAP2K4; NFKB1; PIK3CA; HSPA1L; POLR3K; MAP2K7
Viral carcinogenesis
PKM; HIST1H4J; UBR4; HIST1H2BH; HLA-G; PIK3R2; MAD1L1; C3; HIST2H4; HIST1H2BQ

Protein Function

LYN has several biochemical functions, for example, ATP binding, SH3 domain binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LYN itself. We selected most functions LYN had, and list some proteins which have the same functions with LYN. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PDPK1B; NRK; STK32B; CLCN6; ACTR3; DHX35; CHKA; PFKP; PTK2; RAD51C
Function SH3 domain binding
Related Protein CTTNBP2; PAK3; REPS1; ILK; FAM125A; BCAR1; INPP5J; LYN; ENKUR; MAPT
Function enzyme binding
Related Protein HIST1H2AK; TRP53; RARA; EIF2AK3; PARK2; HYAL2; H2AFX; PRTN3; ATF7; HIST1H2AE
Function gamma-tubulin binding
Related Protein WASH; NDN; BRCA2; B9D2; RAD51D; PIFO; SPATC1; MARK4; BLOC1S2A; NME2
Function glycosphingolipid binding
Related Protein LAMA1; LAMB1; Il2; LAMC1; SELP; SELL; Cel; LYN
Function integrin binding
Related Protein MMP14; ANXA7; Tcam1; CTGFB; TSPAN8; FN1; ITGA6; ILK; SYK; ACTN2
Function ion channel binding
Related Protein PANX1; CIB1; KCNIP1; PRNP; PDE4D; FKBP1B; RIMS1; ACTN2; AKAP9; TCAP
Function non-membrane spanning protein tyrosine kinase activity
Related Protein DYRK1A; ABL2; TNK2B; Fert2; BAZ1B; TXK; FYNA; TYK2; YRK; BMX
Function phosphoprotein binding
Related Protein LRP11; SAG; PKD2; PRKCSH; PAFAH1B1; GPRIN1; APTX; CBX4; MID2; TRPV1
Function platelet-derived growth factor receptor binding
Related Protein IL1R1; PTPRJ; TYMP; LYN; FIGF; PDGFAA; PDGFRA; ITGB3; PDGFAB; PDGFC
Function protein binding
Related Protein VEGFA; FAM176B; HEBP2; GIP; NCOA5; SH2B1; BRSK1; EIF3J; LHX9; USP42
Function protein tyrosine kinase activity
Related Protein LCK; DYRK2; YES1; EK1; FER; ERBB3A; TEK; CLK2; JAK2B; FGFR2
Function receptor binding
Related Protein CADM2A; EPHX2; HLA-F; FGF24; TNFSF10; NRXN1; TMEM38A; UTS2; F7; TNFSF9
Function receptor signaling protein tyrosine kinase activity
Related Protein SYK; EGFR; ERBB4A; INSR; KITB; ERBB3B; EGFRA; ERBB4; ERBB2; LYN
Function ubiquitin protein ligase binding
Related Protein ABI2; RPA2; RANGAP1; RNF20; H2-AB1; SUMO1; HDAC6; EIF4E2; TRAF3; PARK2

Interacting Protein

LYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LYN here. Most of them are supplied by our site. Hope this information will be useful for your research of LYN.
EGFR; polg_hcvh; polg_hcvco; KHDRBS1; polg_hcvj4; PTK2; tip_shv2c

LYN Related Articles

Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
Xiao, ZG; Sperl, B; et al. Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status. ONCOTARGET 5:12877-12890(2014).