mad2l2
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  • Official Full Name
  • MAD2 mitotic arrest deficient-like 2
  • Background
  • The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.
  • Synonyms
  • MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast); MAD2 (mitotic arrest deficient, yeast, homolog) like 2; mitotic spindle assembly checkpoint protein MAD2B; MAD2B; mitotic arrest deficient homolog like 2; REV7; hREV7; REV7 homolog; MAD2-like protein 2
Cat.#:MAD2L2-685HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAD2L2 Protein, MYC/DDK-tagged
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Cat.#:MAD2L2-683HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAD2L2, GST-tagged
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Cat.#:MAD2L2-3528RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAD2L2 Protein
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Cat.#:MAD2L2-2620RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAD2L2 Protein, His-tagged
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Cat.#:MAD2L2-2212CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAD2L2
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Cat.#:MAD2L2-4567HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAD2L2 293 Cell Lysate
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Involved Pathway

MAD2L2 involved in several pathways and played different roles in them. We selected most pathways MAD2L2 participated on our site, such as Bacterial invasion of epithelial cells, Cell cycle, DNA Damage Bypass, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAD2L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Bacterial invasion of epithelial cells
CAV2; RHOG; ARPC3; CBLC; ARPC4; ARPC1B; CRKL; WASL; ARPC5; DNM2
Cell cycle
DBF4; SDCCAG8; CENPL; CDK1; TUBG1; CDKN1C; TCTN2; CUL1B; SMC2; HIST2H3C
DNA Damage Bypass
MAD2L2; ZBTB32; KIAA0101; USP43A; POLD3; RAD18; DDB1; USP10; UBE2L6; USP43
DNA Repair
BARD1; PPP4CB; COPS3; INO80E; INO80C; RNF111; RBBP8; RAD9; RNF168; POLD3
Oocyte meiosis
ESPL1; CALM2; CALML3; PPP3CCB; PLK1; MAPK1; MAPK12B; IGF1RB; PRKACAA; YWHAH
Progesterone-mediated oocyte maturation
PRKACBB; RPS6KA3A; FZR1A; CPEB3; IGF1RB; ANAPC1; CDK1; MAPK8; CCNB2; GNAIA
Shigellosis
ARPC5L; RIPK2; U2AF1; UBE2D2; HCLS1; RELA; CDC42; BTRC; MAD2L2; NFKB1
Translesion synthesis by POLI
MAD2L2; POLI

Protein Function

MAD2L2 has several biochemical functions, for example, JUN kinase binding, RNA polymerase II activating transcription factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAD2L2 itself. We selected most functions MAD2L2 had, and list some proteins which have the same functions with MAD2L2. You can find most of the proteins on our site.
Function
Related Protein
Function JUN kinase binding
Related Protein MAPK8IP3; PTK2; GSTP1; SPAG9; MAD2L2; SPAG9A
Function RNA polymerase II activating transcription factor binding
Related Protein PITX2; TBX3; NFE2L2; BEX1; CREBBP; BHLHE40; SMAD3; HIPK2; TBX20; ZFPM1
Function protein binding
Related Protein UNC13D; THY1; DCP2; DUSP2; RAB17; RFPL3; SCOC; STX5; GAS1; BABAM1

Interacting Protein

MAD2L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAD2L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAD2L2.
CHAMP1; REV3L; ADAM9; ipaB; SFI1