magi2
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  • Official Full Name
  • membrane associated guanylate kinase, WW and PDZ domain containing 2
  • Background
  • The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.
  • Synonyms
  • MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; ACVRIP1; AIP1; ARIP1; KIAA0705; MAGI 2; WW and PDZ domain-containing protein 2; Activin receptor interacting protein 1; Acvri1; Acvrinp1; AIP 1; Aip-1; Atrophin 1 interacting protein 1; Atrophin 1 interacting protein A; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; MAGI-2; MAGI2_HUMAN; Membrane associated guanylate kinase 2; Membrane associated guanylate kinase inverted 2; Membrane associated guanylate kinase WW and PDZ domain containing 2; Membrane associated guanylate kinase WW and PDZ domain containing protein 2; Membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 2; S SCAM; SSCAM
Cat.#:MAGI2-334HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAGI2 Protein, MYC/DDK-tagged
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Cat.#:MAGI2-709HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAGI2, GST-tagged
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Cat.#:MAGI2-9462MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAGI2 Protein
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Cat.#:MAGI2-3542RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAGI2 Protein
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Cat.#:MAGI2-4374CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAGI2
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Cat.#:MAGI2-6569ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAGI2
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Involved Pathway

MAGI2 involved in several pathways and played different roles in them. We selected most pathways MAGI2 participated on our site, such as Rap signaling pathway, Tight junction, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAGI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
PRKCA; PDGFD; INSR; VEGFA; FGF20; FGF17; MAP2K1; CALM4; VASP; CALM2
Tight junction
CLDN17; ASH1L; CLDN10A; MYL10; SPTAN1; PPP2CA; EPB41L3B; EPB41L2; CRB3A; MYL2
TNF signaling pathway
TRADD; PGAM5; CREB5; CXCL1; BCL3; LTA; MMP3; MAP3K7; Ccl12; CXCL10

Protein Function

MAGI2 has several biochemical functions, for example, SMAD binding, beta-1 adrenergic receptor binding, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAGI2 itself. We selected most functions MAGI2 had, and list some proteins which have the same functions with MAGI2. You can find most of the proteins on our site.
Function
Related Protein
Function SMAD binding
Related Protein BMPR1B; PURB; TGFBR3; AXIN1; SOD3; SKOR1A; EP300; CTNNB1; COL5A2; TGFBR2
Function beta-1 adrenergic receptor binding
Related Protein DLG4; MAGI2
Function phosphatase binding
Related Protein PPP1R21; MAPK3; SH3RF2; CSRNP2; SYTL2; KLRAQ1; ELFN2; PPP1R18; PPP1R26; WNK1
Function protein binding
Related Protein USP42; ELF4; FIBPB; OLFM2; NRCAM; IPO4; NCLN; CHCHD1; NPM2; LRSAM1
Function receptor signaling complex scaffold activity
Related Protein MAGI2; CD3G; GRIP1; NCK1; ROPN1B; RGS14; CD3E; LRRK2; G3BP2; SPAG9
Function signal transducer activity
Related Protein OLFR5; CNOT7; CTNNB2; OPN4XA; TACR3A; OLFR15; TAS2R143; SHISA5; TAAR13C; STAT5A
Function type II activin receptor binding
Related Protein INHBA; MAGI2

Interacting Protein

MAGI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAGI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAGI2.
ADRB1; RAPGEF2; TGFA; POLR2A; POLR2B; AMOTL1; q8clu2_yerpe; DSCAML1; PLXNB3

MAGI2 Related Articles

Wolters, VM; Alizadeh, BZ; et al. Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability. HUMAN IMMUNOLOGY 71:392-396(2010).
McGovern, DPB; Taylor, KD; et al. MAGI2 Genetic Variation and Inflammatory Bowel Disease. INFLAMMATORY BOWEL DISEASES 15:75-83(2009).

MAGI2 Related Gene Family

TGF