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  • Official Full Name
  • male germ cell-associated kinase
  • Background
  • The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • MAK; male germ cell-associated kinase; serine/threonine-protein kinase MAK; dJ417M14.2; serine/threonine protein kinase MAK; male germ cell-associated kinase retinal-enriched isoform; RP62
Cat.#:MAK-35HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAK, GST-tagged
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Cat.#:MAK-712HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAK, GST-tagged
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Cat.#:MAK-9468MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAK Protein
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Cat.#:MAK-3547RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAK Protein
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Cat.#:MAK-10312ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAK
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Cat.#:MAK-1048HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAK cell lysate
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Involved Pathway

MAK involved in several pathways and played different roles in them. We selected most pathways MAK participated on our site, such as Coregulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Coregulation of Androgen receptor activity
KDM4C; SNURF; TGFB1I1; PA2G4; CMTM2A; NRIP1; CMTM2; MAK; CTDSP2; PAWR

Protein Function

MAK has several biochemical functions, for example, ATP binding, cyclin-dependent protein serine/threonine kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAK itself. We selected most functions MAK had, and list some proteins which have the same functions with MAK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein EPHB4B; UCK1; P2RX2; SETX; CCT3; LIMK1A; KIF2C; PRKACAB; HSPA7; GLUL
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein CDK9; CDK2; PFTK1; CDK5; MAK; NAT1; CDK8; CDK20; CDK1; CDK15
Function protein binding
Related Protein BCAR1; HNRPDL; PLEKHB1; COL6A5; PEF1; MYL12A; RARRES2; KLRB1B; SYNGR1; PPP5C
Function protein kinase activity
Related Protein PAK2A; CSNK1A1; NEK12; DCLK1A; LMTK2; NPR2; TRIM28; DCKL1B; WNK2; CLK2A
Function transcription coactivator activity
Related Protein JUND; MED12; DYRK1B; TUBB3; NPAT; MKL1B; KAT2B; NFATC4; NPM1; WWTR1

Interacting Protein

MAK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAK here. Most of them are supplied by our site. Hope this information will be useful for your research of MAK.
FZR1; AR; CDC37; CDK20; NDUFB7; PPP2CB; SND1; SLAMF7; SERINC1; ANAPC11

MAK Related Articles

Scalioni, LD; Cruz, HM; et al. Importance of Collection Methods and Stability of Oral Fluid Samples for Hepatitis B Surface Antigen Detection. JOURNAL OF CLINICAL LABORATORY ANALYSIS 27:186-194(2013).
Barrio, MM; Abes, R; et al. Human Macrophages and Dendritic Cells Can Equally Present MART-1 Antigen to CD8(+) T Cells after Phagocytosis of Gamma-Irradiated Melanoma Cells. PLOS ONE 7:-(2012).