map3k11
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  • Official Full Name
  • mitogen-activated protein kinase kinase kinase 11
  • Background
  • The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
  • Synonyms
  • MAP3K11; mitogen-activated protein kinase kinase kinase 11; MLK3, PTK1; MEKK11; SPRK; mixed lineage kinase 3; protein-tyrosine kinase PTK1; SH3 domain-containing proline-rich kinase; src-homology 3 domain-containing proline-rich kinase; MLK3; PTK1; MLK-3
Cat.#:MAP3K11-9507MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAP3K11 Protein
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Cat.#:MAP3K11-3564RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAP3K11 Protein
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Cat.#:MAP3K11-2666RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAP3K11 Protein, His-tagged
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Cat.#:MAP3K11-1039HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 11, GST-Tagged
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Cat.#:MAP3K11-1257HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 11, GST-tagged
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Involved Pathway

MAP3K11 involved in several pathways and played different roles in them. We selected most pathways MAP3K11 participated on our site, such as MAPK signaling pathway, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CD14; MAPK13; CACNA1G; FGF2; CACNG6; MAP2K3; ARR3A; CDC25B; ACVR1C; HRAS
Non-alcoholic fatty liver disease (NAFLD)
CEBPA; MAPK8; IL1B; COX6B2; IRS2; SREBF1; GSK3B; ADIPOQ; CASP7; UQCRC1

Protein Function

MAP3K11 has several biochemical functions, for example, ATP binding, JUN kinase kinase kinase activity, Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K11 itself. We selected most functions MAP3K11 had, and list some proteins which have the same functions with MAP3K11. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RAD17; MYO10; NLRP7; ATP13A1; TK2; NUBP2; TRIP13; ATM; PLK3; MADD
Function JUN kinase kinase kinase activity
Related Protein MAP3K11; MAP3K10; MAP3K9; MAP3K1; ALPK2
Function Rac GTPase binding
Related Protein ARFIP2; EPS8; ITPKA; NCF2; ARHGAP4; SRGAP1; SRGAP2B; PAK6; CDKL5; PAK2A
Function identical protein binding
Related Protein TYROBP; MTSS1; GRB2; SSNA1; MRFAP1L1; CLDN16; CRYAB; TK1; PLN; SEPT7
Function mitogen-activated protein kinase kinase binding
Related Protein PIN1; ARRB1; BRAF; RAF1; MAPK8IP3; MAP3K11; TAOK2; TRIB2; KSR1; TRIB1
Function mitogen-activated protein kinase kinase kinase binding
Related Protein MAP4K2; PPEF2; MARVELD3; TRAF2; CDC42; MAPK9; STK38; CDC37; MAP2K1; MAPK8IP3
Function protein binding
Related Protein SLC30A1; IL1RN; AXIN2; F2RL1; PSMC2; BEGAIN; HOXD12; PRKAB2; SNX4; THY1
Function protein homodimerization activity
Related Protein NUDT16; CEACAM5; CARD8; DROSHA; KIF20B; B4GALT1; ANO6; TSG101; PON3; OLIG2
Function protein kinase activity
Related Protein GSG2; PDK4; CDK7; PLK5; MAPK14B; SCYL2; SNRKB; PTK2AB; ERBB3B; CDK12
Function protein serine/threonine kinase activity
Related Protein IRAK1; PAK1; CSNK1G3; ROCK2; SMOK3B; NEK11; CSNK2A2; NUAK1; MAPK14; STK32B
Function protein tyrosine kinase activity
Related Protein EGFR; ERBB2; FGR; MUSK; KIT; FGFR1A; CAMKK2; BAZ1B; WEE1; AXL

Interacting Protein

MAP3K11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K11.
NF2; q99ib8-pro_0000045602; CDC42; Map4k1; PIK3R1; saicar; PKM

MAP3K11 Related Articles

Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).