mapk10
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  • Official Full Name
  • mitogen-activated protein kinase 10
  • Background
  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3;
Cat.#:MAPK10-154HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK10 protein, His/MBP-tagged
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Cat.#:MAPK10-239HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK10 protein, His-tagged
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Cat.#:MAPK10-27604THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK10
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Cat.#:MAPK10-27605THTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK10
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Cat.#:MAPK10-339HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK10, GST-tagged, Active
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Cat.#:MAPK10-691HTag:His/GST
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 10, GST-His
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Cat.#:MAPK10-752HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 10
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Cat.#:MAPK10-2671RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAPK10 Protein, His-tagged
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Cat.#:MAPK10-3593ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK10
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Cat.#:MAPK10-1044HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 10, GST-tagged
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Cat.#:MAPK10-4497HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK10 293 Cell Lysate
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Cat.#:MAPK10-4498HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK10 293 Cell Lysate
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Cat.#:MAPK10-4499HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK10 293 Cell Lysate
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Involved Pathway

MAPK10 involved in several pathways and played different roles in them. We selected most pathways MAPK10 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
GRB2; PRKACA; ATF4; PRKACB; MKNK2B; FGFR4; FGF11; MKNK2A; Fasl; TGFB1
ErbB signaling pathway
RPS6KB1; MAP2K4B; NCK1; CDKN1BA; CBLB; HRASA; PAK6B; AREG; SHC1; PAK1
Ras signaling pathway
RALBP1; PLA2G4F; ABL1; FIGF; RELA; FGFR3; PIK3R2; RIN1; PDGFB; FLT1
cAMP signaling pathway
RELA; VAV2; GLP1R; GABBR1; FSHB; CALML3; RAC3; MC2R; GNAI3; HTR1E
FoxO signaling pathway
SGK2B; EP300; PRKAB1A; ATM; PIK3R2; CCND2; MAPK14A; PTENB; FOXG1A; PRKAG3B
Sphingolipid signaling pathway
PLCB4; BID; KRAS; PIK3R3; GNA12; SGPL1; FCER1G; NFKB1; PPP2R2A; PLCB1
Protein processing in endoplasmic reticulum
CAPN1A; SEC24D; SAR1B; BAG1; UBE2D2; SEC31B; SEC61G; PKZ; RRBP1B; WFS1
Wnt signaling pathway
MAP3K7; PRKACAA; FOSL1; PRKACAB; SENP2; PRKCB; EP300; FZD3; CAMK2G; DVL1B
Osteoclast differentiation
PPP3R1; TGFBR1; FCGR3B; MAPK3; TRAF6; MAP3K7; IFNAR2; TRAF2; FCGR3A; TYK2
Focal adhesion
FYNA; MYL12B; FN1; ITGB3; VASPA; CAPN2; ITGA4; BCAR1; LAMC2; CCND3
Toll-like receptor signaling pathway
TLR1; TLR4BB; CCL3; IL12BA; RELA; IFNAR1; MAPK1; IFNA7; Ifna11; CCL5
NOD-like receptor signaling pathway
IKBKG; IL8L2; SUGT1; MAPK1; NLRP1; MAP3K7; NFKBIAA; IKBKB; RIPK2; CXCL1
RIG-I-like receptor signaling pathway
NFKB1; IFNA3; MAPK8B; IKBKE; IL12B; IFNA4; IRF3; TBKBP1; MAPK14B; ATG12
Fc epsilon RI signaling pathway
PDPK1; FYN; GAB2; GRB2; INPP5D; GM-CSF; BTK; SOS1; SYK; IL5
TNF signaling pathway
MAP2K1; CASP8; DNM1L; Casp3; IL6; PIK3CB; NFKBIA; IL15; PIK3CG; ATF4
Neurotrophin signaling pathway
KRAS; PRKCD; TRP53; RAPGEF1; TP53; BRAF; SH2B1; NTRK2; PRDM4; CDC42
Retrograde endocannabinoid signaling
GNG8; GABRA5; Adcy4; GRIA4; GABRA3; GABRD; SLC17A8; GABRB1; PRKCA; GABRQ
Dopaminergic synapse
GNAI2; MAPK12; PLCB3; ITPR1; GRIN2A; SLC18A2; GSK3A; SLC6A3; ARRB2; CREB3
Inflammatory mediator regulation of TRP channels
MAPK11; PRKCH; ALOX12E; TRPV4; ASIC1; ITPR3; PLCG1; CYP2C38; PLA2G4F; CALM4
Insulin signaling pathway
RAF1B; PIK3CA; MTOR; CALM2; CALM4; SH2B2; IKBKB; PRKAR1AB; G6PC2; INPPL1A
GnRH signaling pathway
RAF1B; CALM3B; GNAS; GNRH2; CACNA1D; GRB2; CAMK2D; RAF1; CDC42L2; CAMK2D2
Progesterone-mediated oocyte maturation
Adcy4; RPS6KA3B; CDC25C; ADCY2B; IGF1; MAPK10; HSP90AA1; GNAI2; PLK1; CCNB2
Prolactin signaling pathway
STAT5A; MAPK10; ELF5; PIK3R3; PIK3R5; FOS; MAP2K2; RELA; SOS1; LHB
Adipocytokine signaling pathway
ACSBG1; G6PC2; TNFRSF1B; MAPK8A; STAT3; CAMKK2; RXRAA; PTPN11A; MAPK10; ACSL4A
Type II diabetes mellitus
PRKCZ; PIK3R2; IRS4; IRS2; PKM; HKDC1; MAFA; PIK3R3; TNF; MAPK9
Insulin resistance
PRKCBB; PRKAB2; STAT3; RPS6KA1; PDPK1B; SLC27A1B; PPARGC1A; PPP1CA; SOCS3B; RPS6KA2
Non-alcoholic fatty liver disease (NAFLD)
NDUFV3; NDUFB10; COX4I2; NDUFA9; SDHD; GSK3A; PRKAA2; EIF2AK3; FASLG; NDUFS8
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1F; MAPK9; TJP1; TCIRG1; IL-8; MAPK13; RAC1; ATP6V1E2; JAM3; ATP6V0E1
Shigellosis
DIAPH1; ARPC5L; SRC; IKBKG; WASF1; PFN4; MAPK8; CTTN; U2AF1L4; ABL1
Salmonella infection
TLR4BA; ROCK2; IL1A; TLR4; MAPK1; CCL4; TJP1; MAPK10; RAC1A; CCL4L1
Pertussis
FOS; Il23a; Il12b; MAPK9; IL23; Casp3; MAPK8; CALML3; TRAF6; NFKB1; Hc
Chagas disease (American trypanosomiasis)
ACE; NOS2; GNAQ; MAPK13; GNAL; TLR6; NFKBIA; TNF; TICAM1; IL10
Toxoplasmosis
TRAF6; TNF; HSPA1B; NFKB1; H2-AA; STAT3; Toxoplasma Gondii Dense Granule Protein 7; PIK3R1; LY96; HLA-DOA
Tuberculosis
C3; RAF1; RAB7; PPP3R1; RFXANK; IFNA8; NFYC; FADD; SPHK2; MAPK9
Hepatitis C
CLDN22; CLDN6; IFNA14; CLDN5; PIK3R2; PPP2R2D; TYK2; TP53; IFNA12; OCLN
Hepatitis B
TICAM2; NFATC3; IKBKE; CCNA1; VDAC3; MYD88; PIK3R3; IFNA17; CREB3L3; IFNA12
Influenza A
CYCS; FASLG; BLB1; RSAD2; IL8L1; EP300; TLR7; MAP2K3; IL1B; LOC780933
Herpes simplex infection
TAB2; HLA-C; CLOCKA; NFKBIA; SRSF2B; CSNK2A2A; MHC2DCB; TAF5; CLOCK; FB06F03
Epstein-Barr virus infection
HLA-B; PSMC5; CCNA1; CD19; EIF2AK1; HLA-DRB5; POLR3B; RIPK1; PSMC1; POLR3C
Pathways in cancer
GNA12; FZD1; MAP2K2; FOXO1; ITGA6; HDAC1; TCF7; PIK3R3; MAPK3; HIF1A
Colorectal cancer
TGFB1; RAC2; DCC; MAPK8; RALGDS; MSH2; MLH1; BAD; RAC1; FOS
Pancreatic cancer
BRAF; SMAD3; MAPK3; TGFB1; AKT1; PIK3CA; TGFBR1; RAC2; RELA; IKBKG
Choline metabolism in cancer
DGKE; SOS1; PRKCG; CHKB; MAPK9; CHKA; MTOR; PLA2G4F; GRB2; DGKD

Protein Function

MAPK10 has several biochemical functions, for example, ATP binding, JUN kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK10 itself. We selected most functions MAPK10 had, and list some proteins which have the same functions with MAPK10. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KIF5AA; NME2A; PTK2BB; IARS; EIF2AK4; ABCF3; BMPR2B; KLHL8; NEK3; TOR2A
Function JUN kinase activity
Related Protein MAPK8; MAPK9; ALPK2; MAPK10
Function MAP kinase kinase activity
Related Protein MAPK10; ALPK2; MAP2K3; MAP3K20; MAP2K1; MAP2K7; MAP3K9; MAP2K2A; PAK3; MAP3K14
Function protein binding
Related Protein GFM2; SRPK1; LAMA1; NEK6; BCL7A; UBAC1; ALOX5AP; TOR1AIP2; STK24; SEC61B

Interacting Protein

MAPK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK10.
ARRB1; JUN; HAX1; RELA; ARRB2; CEP290; GTF3C1; UNC119; TNIP1; CREBBP; PLIN2; KIF26A; linkable pd173955 analogue; gefitinib; WDR62

MAPK10 Related Articles

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).