mapk10
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  • Official Full Name
  • mitogen-activated protein kinase 10
  • Background
  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3;
Cat.#:MAPK10-154HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK10 protein, His/MBP-tagged
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Cat.#:MAPK10-239HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK10 protein, His-tagged
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Cat.#:MAPK10-27604THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK10
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Cat.#:MAPK10-27605THTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK10
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Cat.#:MAPK10-339HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK10, GST-tagged, Active
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Cat.#:MAPK10-691HTag:His/GST
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 10, GST-His
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Cat.#:MAPK10-752HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 10
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Cat.#:MAPK10-2671RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAPK10 Protein, His-tagged
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Cat.#:MAPK10-3593ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK10
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Cat.#:MAPK10-1044HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 10, GST-tagged
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Cat.#:MAPK10-4497HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK10 293 Cell Lysate
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Cat.#:MAPK10-4498HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK10 293 Cell Lysate
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Cat.#:MAPK10-4499HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK10 293 Cell Lysate
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Involved Pathway

MAPK10 involved in several pathways and played different roles in them. We selected most pathways MAPK10 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP2K2; FGF13; FGF20B; RAC3A; FGF1B; NTF3; MAPK8; RAC3B; CACNB1; CASP3A
ErbB signaling pathway
PTK2AB; MAP2K1; MAPK10; PLCG2; PRKCBA; SHC4; STAT5B; MAP2K2; BTC; CAMK2D
Ras signaling pathway
PRKCA; FGF14; FGF22; NRAS; GAB2; RASAL2; GNG4; GNB1; RAC3; BAD
cAMP signaling pathway
CREB3L2; GABBR1; PIK3R5; CNGA4; GRIA1; GRIA2; PIK3CD; PIK3R3; FSHB; VAV1
FoxO signaling pathway
SMAD3; PLK4; TGFBR2; MAPK11; KRAS; IGF1RB; FOXO3B; INSR; PRKAB1B; FOXO6
Sphingolipid signaling pathway
CERS2; BID; MAPK12; SPTLC1; GNAQ; SPTLC2; PRKCE; PLD2; PDPK1; S1PR4
Protein processing in endoplasmic reticulum
LMAN1L; SEC61A1; SEC63; ATF4; HSPA8; BCL2A; AMFR; SYVN1; P4HB; DNAJC10
Wnt signaling pathway
DVL1B; MAPK8A; PRICKLE1A; FZD8; BAMBI; TBL1XR1; FZD3B; PRKCG; WNT11B; CTNNBIP1
Osteoclast differentiation
IL1A; CSF1R; NFATC2; PIK3CA; TAB2; SOCS1; SOCS3; AKT2; LILRB4; TNFRSF1A
Focal adhesion
THBS4A; FYNB; THBS1; PTK2; SHC3; ITGA10; CAV3; COL2A1A; EGFRA; PTK6
Toll-like receptor signaling pathway
IRF5; TLR4; IL6; AKT3A; CXCL11; TLR8; IFNAR2; IFNA16; CCL4L2; IFNPHI3
NOD-like receptor signaling pathway
PYCARD; CASP8; ERBB2IP; MAPK10; NLRP3; MAPK8A; TNFAIP3; NFKB1; HSP90AA1.2; HSP90AA1
RIG-I-like receptor signaling pathway
MAPK14A; NFKB1; DDX3; ISG15; CASP8; TNF; RNF125; TBK1; IFNA17; MAPK13
Fc epsilon RI signaling pathway
MAPK8; PLCG1; PLA2G4C; GM-CSF; INPP5D; LAT; FCER1G; GRB2; KRAS; RAF1
TNF signaling pathway
PIK3R5; MAP2K3; Ccl12; IKBKB; LTA; CXCL3; MAPK3; MAPK11; IL15; MAP3K7IP3
Neurotrophin signaling pathway
TRP53; MAPK9; RAC1; MAPK13; AKT2; CAMK2D; CALML3; ABL1; SHC2; MAPK3
Retrograde endocannabinoid signaling
GNB2; ABHD6; GABRR3; GABRA3; GRIA3; RIMS1; MAPK11; GNG2; GABRA4; NAPEPLD
Dopaminergic synapse
PPP2R5A; DRD5; GNG4; PRKCB; GNB4; PPP2R2B; CLOCK; CALML5; MAOA; GNB3
Inflammatory mediator regulation of TRP channels
HTR2B; MAP2K3; CALM4; ALOX12; CYP2C55; PPP1CA; KLK1B4; ASIC5; HTR2C; CAMK2D
Insulin signaling pathway
FOXO1; PYGM; AKT2; RAF1; PIK3CA; PPP1CAB; PIK3R2; HK1; CALM3B; RHOQ
GnRH signaling pathway
GNRHR; MAP2K4A; GNA11A; MAP3K4; MMP14A; MAPK7; HBEGFA; CAMK2B; MAPK14B; CALM2A
Progesterone-mediated oocyte maturation
PRKACAB; CPEB3; MAP2K1; CCNA1; PIK3CG; FZR1; ADCY1B; RPS6KA3B; MAPK13; CDK1
Prolactin signaling pathway
FOXO3; STAT5A; PIK3R5; SLC2A2; TNFSF11; PRL; KRAS; PRP2; STAT3; GALT
Adipocytokine signaling pathway
LEPB; PRKAB1A; ACSL4A; ADIPOQ; STAT3; MAPK8A; ACSL3; PRKCQ; PRKAG3; AKT3A
Type II diabetes mellitus
PIK3R5; ADIPOQ; PIK3CG; CACNA1G; INSR; INS1; HK2; PIK3R3; IRS1; MAPK10
Insulin resistance
FOXO1A; IKBKB; GSK3AA; INSRB; PTENB; NFKBIAB; CREB3L3A; AKT1; PRKAG3; RPS6KA1
Non-alcoholic fatty liver disease (NAFLD)
SOCS3; NDUFS7; PRKAG2; SREBF1; NDUFV2; IL-8; FASLG; TNFRSF1A; TGFB1; PIK3R3
Epithelial cell signaling in Helicobacter pylori infection
JAM3; ATP6V0A4; ATP6V1B1; ATP6V1E2; ATP6AP1; ATP6V0B; ATP6V0C; TJP1; MAP2K4; ATP6V1C2
Shigellosis
MAPK12; RAC1; IKBKB; MAD2L2; PFN4; IL-8; ITGB1; ELMO2; ROCK1; WASF1
Salmonella infection
MAPK8; DYNC2H1; IL18; MYH9; FLNC; CDC42L; TLR4BB; DYNC1LI2; LBP; PFN2L
Pertussis
NFKB1; C1RA; MAPK9; C4BPB; IL-8; TLR4; C4BPA; ITGB1; GM5077; IL12A
Chagas disease (American trypanosomiasis)
PPP2CB; PPP2R2A; PLCB1; CD3D; GNA15; SMAD3; MAPK9; TGFBR1; PPP2R2D; IFNG
Toxoplasmosis
MAP2K6; PPIF; LAMA2; CD40LG; BCL2L1; BIRC3; Casp3; PDPK1; PIK3R5; HSPA8
Tuberculosis
HLA-DRB3; IL18; ITGB2L; IFNA21; RFX5; TLR9; CLEC7A; BCL2; Casp3; FCGR1
Hepatitis C
OAS1A; CLDN11; BAD; IFNA5; TBK1; PPP2R1A; CLDN14; CLDN3; TRAF6; MAPK9
Hepatitis B
TP53; IL-8; NFATC4; IFNA5; Casp3; IKBKG; DDX3X; MAPK10; DDX58; IFIH1
Influenza A
HSPA1A; IL33; AKT1; HLA-DRB1; MAPK10; TLR4; STAT1; Ccl12; IFNGR2; KPNA2
Herpes simplex infection
IFNA6; PVRL1; PER1B; PVRL2; TLR2; OAS2; TRP53; IKBKG; SP100; STAT1
Epstein-Barr virus infection
HLA-DRB4; TRAF6; NFKBIB; CD38; POLR3F; PSMD8; PSMD4; PSMD1; GTF2B; EIF2AK3
Pathways in cancer
KRAS; FZD9; GNB2; Adcy4; SUFU; NKX3; BDKRB1; CDC42; TGFA; GSTP1
Colorectal cancer
TGFB2; FOS; BRAF; APC; APPL1; MAPK9; MSH6; BCL2; RAF1; MAP2K1
Pancreatic cancer
MAPK1; STAT1; TGFB1; RALGDS; SMAD2; PIK3CD; TRP53; STAT3; PIK3CB; RALBP1
Choline metabolism in cancer
PDGFRA; PIK3R1; PIP5K1C; PDPK1; RAF1; WAS; MAP2K1; SLC22A1; PIP5K1A; Pdgfa&Pdgfb

Protein Function

MAPK10 has several biochemical functions, for example, ATP binding, JUN kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK10 itself. We selected most functions MAPK10 had, and list some proteins which have the same functions with MAPK10. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KLHL8; NTPCR; TTLL2; NTRK2; CAMK1D; ALPK1; MAPK8; HSP104; HSP70L; NME6
Function JUN kinase activity
Related Protein MAPK8; ALPK2; MAPK10; MAPK9
Function MAP kinase kinase activity
Related Protein MAPKAPK5; MAP2K1; MAP2K7; MAP2K6; MAP2K3; MAPK10; ALPK2; MAP3K9; MAP2K2B; SBK3
Function protein binding
Related Protein MED1; TMEM183A; ADRB2; EPN3; SDHA; TBX5; APBB3; TYROBP; AIDA; LRP6

Interacting Protein

MAPK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK10.
ARRB1; JUN; HAX1; RELA; ARRB2; CEP290; GTF3C1; UNC119; TNIP1; CREBBP; PLIN2; KIF26A; linkable pd173955 analogue; gefitinib; WDR62

MAPK10 Related Articles

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).