mapk10
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  • Official Full Name
  • mitogen-activated protein kinase 10
  • Background
  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3;
Cat.#:MAPK10-154HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK10 protein, His/MBP-tagged
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Cat.#:MAPK10-239HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK10 protein, His-tagged
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Cat.#:MAPK10-27604THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK10
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Cat.#:MAPK10-27605THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPK10
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Cat.#:MAPK10-339HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK10, GST-tagged, Active
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Cat.#:MAPK10-691HTag:His|GST
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 10, GST-His
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Cat.#:MAPK10-752HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 10
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Cat.#:MAPK10-2671RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAPK10 Protein, His-tagged
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Cat.#:MAPK10-3593ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK10
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Cat.#:MAPK10-1044HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 10, GST-tagged
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Cat.#:MAPK10-4497HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPK10 293 Cell Lysate
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Cat.#:MAPK10-4498HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPK10 293 Cell Lysate
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Cat.#:MAPK10-4499HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPK10 293 Cell Lysate
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Involved Pathway

MAPK10 involved in several pathways and played different roles in them. We selected most pathways MAPK10 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PRKCBA; MAP2K4; PPP3CA; GNA12; PPP3R2; ARR3B; GADD45B; FGF1A; FGF5; MAPK4
ErbB signaling pathway
MAPK9; CAMK2B; PAK1; PIK3R3; AKT2L; CAMK2G1; NRG2B; MAP2K2; ELK1; ERBB3A
Ras signaling pathway
RAPGEF5; NFKB1; AKT1; BAD; PRKCB; CALML5; PLA2G4A; GNG10; ZAP70; RASA4
cAMP signaling pathway
PPP1CC; RRAS; GRIA2; VIPR2; GRIN1; OXTR; NFKB1; MAP2K1; NPY; HTR1F
FoxO signaling pathway
MAPK14A; KLF2; FBXO25; GABARAPL1; SMAD3A; G6PCA.1; RAF1A; G6PC2; KLF2A; CCND1
Sphingolipid signaling pathway
RAF1; LASS1; SMPD2; LASS2; SGPP2; PRKCZ; GNAQ; PIK3R3; RAC2; BID
Protein processing in endoplasmic reticulum
HSP26; HSP90AA1.2; HSP90B1; CRYAB; UBQLNL; MBTPS1; FBXO2; MOGS; EIF2S1B; DNAJC3
Wnt signaling pathway
PRKACA; FZD7B; CUL1; PRKCB; FZD1; PRKCA; FRAT2; VANGL2; PPP3R1B; DKK2
Osteoclast differentiation
IFNB1; TEC; TREM2; CSF1R; NFKB2; TNFSF11; MITF; OSCAR; FCGR2A; TYROBP
Focal adhesion
HGF; VAV3; PPP1CAA; ACTG1; PIK3CA; PTK2; PTEN; ARHGAP5; COL5A2; LAMC3
Toll-like receptor signaling pathway
MAP2K1; TLR9; CD14; TLR5B; IRAK4; MAPK12A; MAP2K2; TOLLIP; MAPK8; CCL4L1
NOD-like receptor signaling pathway
NFKBIAA; CARD18; NAIP1; CXCL1; PSTPIP1B; NFKBIAB; IL8L1; TAB3; PYDC1; MAP3K7
RIG-I-like receptor signaling pathway
DHX58; IFNPHI1; TRAF6; IFNA10; IFNB; MAPK9; IFNB1; IFNA17; ATG5; DDX3X
Fc epsilon RI signaling pathway
MAPK9; FCER1A; MAPK13; PIK3R2; IL5; PDPK1; MAPK12; GAB2; GRB2; RAF1
TNF signaling pathway
VEGFC; MAP2K6; RPS6KA4; MAP2K7; FAS; MAP3K7IP3; MAPK13; TAB2; BCL3; TRADD
Neurotrophin signaling pathway
MATK; KRAS; RPS6KA5; CDC42; IRAK2; IKBKB; MAP3K1; MAPKAPK2; MAP2K1; NGF
Retrograde endocannabinoid signaling
GRM5; GABRA2; GNB4; GNG2; PRKCA; PRKACG; PLCB2; GABRB3; GNG12; GNG13
Dopaminergic synapse
PRKCA; AKT1; GNG4; KIF5B; GNG7; PPP2R2D; CREB3L2; PPP2R1B; MAPK12; GNAI2
Inflammatory mediator regulation of TRP channels
CALM1; MAPK13; TRPV1; TRPM8; SRC; ASIC5; MAPK11; IGF1; PLCG2; NTRK1
Insulin signaling pathway
PHKG1A; PHKG1B; MKNK2; CALM2A; MAPK8B; PRKCZ; MAPK9; FOXO1B; PIK3R2; PPARGC1A
GnRH signaling pathway
CAMK2G; PRKCA; MAPK14A; LHB; GNA15.4; CAMK2D; PRKACG; CALM2B; CAMK2D1; MAP2K1
Progesterone-mediated oocyte maturation
PRKACA; PIK3R1; GNAI2; PIK3R3A; CPEB2; HSP90AA1; AKT1; GNAI3; ANAPC11; RPS6KA3A
Prolactin signaling pathway
SOCS1; STAT1; STAT5B; MAPK12; MAP2K1; PIK3R3; SOCS7; PIK3R1; INS1; SOCS6
Adipocytokine signaling pathway
PCK2; ACACB; PTPN11B; NFKBIAB; ADIPOQ; LEPB; TNF; CD36; ACSL3; PRKAG3
Type II diabetes mellitus
PIK3R2; IRS2; SOCS4; PIK3R3; MTOR; MAFA; INSR; INS1; SOCS3; HK2
Insulin resistance
PRKCE; ACACB; SOCS3; PRKAG3B; TRIB3; NFKB1; PRKAB1; PTPN11A; PTPN11; PRKCBA
Non-alcoholic fatty liver disease (NAFLD)
MAP3K5; PKLR; PIK3R3; PIK3CA; INSR; CDC42; UQCRB; IL-8; TGFB1; NDUFA13
Epithelial cell signaling in Helicobacter pylori infection
ADAM17; PLCG1; ATP6V0A2; NOD1; ATP6AP1; MAPK12; ATP6V0B; ATP6V1D; CXCR2; ATP6V1B2
Shigellosis
MAPK12; RAC1; IKBKG; ROCK2; CTTN; FBXW11; MAPK13; MAPK10; WASF1; ARPC5L
Salmonella infection
RAC1; TLR4; IL8L2; RHOGD; NOS2A; IL18; MYD88; MAPK3; MAPK12A; TLR4BB
Pertussis
C4BPB; CALM4; MAPK10; Hc; CALM1; TLR4; MAPK1; CASP7; IRAK1; IL12A
Chagas disease (American trypanosomiasis)
NFKBIA; MAPK10; MAPK13; PPP2R2A; PPP2R1B; MAPK11; IFNGR1; PPP2R2B; IL1B2; Il2
Toxoplasmosis
HLA-DRA; MAPK9; IFNGR2; H2-AA; STAT1; IRGM1; HLA-DQA2; Toxoplasma Gondii Microneme Protein MIC3; RELA; BIRC3
Tuberculosis
TNFRSF1A; IFNA17; RAB5C; SPHK1; IFNA8; ITGB2L; TNF; SPHK2; FCGR3B; FCER1G
Hepatitis C
IFNA14; MAPK1; MAPK11; IRF7; EIF2AK2; PPP2R2A; EIF2AK4; OAS1; PPP2R2C; CLDN23
Hepatitis B
ATF4; STAT2; SRC; MAP3K1; TGFB3; BAX; TP53; IFNA10; IFNA14; IRF7
Influenza A
IFNA4; PABPN1; EIF2AK4; STAT2; IFNA17; TLR7; IFNAR1; IFNA7; TNFRSF1A; AKT2
Herpes simplex infection
GTF2IRD1; IFNA3; SRSF1B; CUL1A; CD74; TYK2; HLA-DMA; IL6; PER3; TAP2
Epstein-Barr virus infection
HLA-DRB4; PIK3R2; PRKACA; POLR2I; HLA-DPB1; NEDD4; CD58; TRADD; HDAC4; EIF2AK4
Pathways in cancer
RAD51; STAT5B; PPARD; FIGF; HSP90AB1; PTCH2; WNT7A; FGF4; BRCA2; ABL1
Colorectal cancer
CCND1; RAC2; RAF1; RAC3; PIK3R3; MAPK8; RALGDS; LEF1; TGFB3; TRP53
Pancreatic cancer
RELA; PIK3R5; KRAS; RALBP1; BRCA2; RALGDS; BRAF; PIK3CG; AKT2; TGFBR2
Choline metabolism in cancer
SLC22A5; AKT2; MAPK1; HIF1A; MAP2K2; AKT1; MAPK10; PPAP2B; EGF; MAPK8

Protein Function

MAPK10 has several biochemical functions, for example, ATP binding, JUN kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK10 itself. We selected most functions MAPK10 had, and list some proteins which have the same functions with MAPK10. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PCXB; DAPK2A; MTOR; IDE; MAPK14A; PAPSS2B; SRPK1; TESK1; CDC42BPB; SRPK1A
Function JUN kinase activity
Related Protein MAPK8; ALPK2; MAPK9; MAPK10
Function MAP kinase kinase activity
Related Protein MAP3K9; MAP2K3; ALPK2; SBK3; PAK3; LRRK2; MAPK14; MAPKAPK5; MAP3K20; MAP2K7
Function protein binding
Related Protein WDYHV1; NKX2; ZNF434; ITGB3BP; BDKRB2; MTMR2; MBNL3; CHMP5; CCDC121; ISYNA1

Interacting Protein

MAPK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK10.
ARRB1; JUN; HAX1; RELA; ARRB2; CEP290; GTF3C1; UNC119; TNIP1; CREBBP; PLIN2; KIF26A; linkable pd173955 analogue; gefitinib; WDR62

MAPK10 Related Articles

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).