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Official Full Name mitogen-activated protein kinase 10
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Synonyms MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK10-3584H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Mapk10-3938M Recombinant Mouse Mapk10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human MAPK10-4539H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK10-1044H Recombinant Human Mitogen-Activated Protein Kinase 10, GST-tagged E.coli GST
    Human MAPK10-154H Recombinant Human MAPK10 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK10-239H Recombinant Human MAPK10 protein, His-tagged E.coli His
    Human MAPK10-27604TH Recombinant Human MAPK10 E.coli N/A
    Human MAPK10-27605TH Recombinant Human MAPK10 N/A
    Human MAPK10-339H Recombinant Human MAPK10, GST-tagged, Active Sf9 Insect Cell GST
    Human MAPK10-4497HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-4498HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-4499HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-691H Recombinant Human Mitogen-activated Protein Kinase 10, GST-His S.frugiperda His/GST
    Human MAPK10-752H Recombinant Human Mitogen-activated Protein Kinase 10 E.coli N/A
    Rhesus Macaque MAPK10-2671R Recombinant Rhesus monkey MAPK10 Protein, His-tagged Mammalian Cell His
    Zebrafish MAPK10-3593Z Recombinant Zebrafish MAPK10 Mammalian Cell His

    MAPK10 involved in several pathways and played different roles in them. We selected most pathways MAPK10 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway NTRK1; RASGRP3; DUSP3; RAP1AB; PPP3R1B; GRB2A; FGF12A; AKT3A; RAC3A; AKT2
    ErbB signaling pathway SOS1; SHC1; RPS6KB2; PIK3CA; CBLB; PRKCBA; CDKN1BB; MAP2K7; HRAS; MAP2K2B
    Ras signaling pathway FGF20; PLCG1; MAPK9; PRKCB; PDGFC; MAPK10; FGF5; FLT4; RASA4; GNG3
    cAMP signaling pathway PIK3R5; CAMK2D; CREB3L3; CALM1; GNAI2; GHSR; CNGA2; GRIN2D; CALML3; PDE4A
    FoxO signaling pathway PRKAA1; G6PC; TGFBR1B; IGF1; RAF1; IGF1R; INSB; MAPK8B; PDPK1B; CCND2
    Sphingolipid signaling pathway AKT2; SGPP2; PPP2R1B; LOC100328615; ASAH2; GNA12; RELA; GNAI3; PPP2R5E; FYN
    Protein processing in endoplasmic reticulum SEC61A1; ERP29; NPLOC4; MAN1A; HSP70L; NFE2L2; HSPA1A; MAPK8A; SAR1B; DNAJB12A
    Wnt signaling pathway CCND2; WNT5B; SKP1; BTRC; DKK2; MAPK8; SOST; RAC3B; PRICKLE1A; CSNK2A2A
    Osteoclast differentiation AKT1; FOSL2; SYK; LILRA4; FCGR2B; NFATC1; LILRB3; IFNG; PIK3R3; TNFRSF1A
    Focal adhesion TNXB; PDPK1; FLT1; ERBB2; SPP1; ROCK2; PIK3CD; KDRL; HRAS; SEPP1
    Toll-like receptor signaling pathway IRF7; IFNA21; TLR4BA; CD40; PIK3R2; MAPK8A; IL8L1; CD14; CCL3L3; CCL4L1
    NOD-like receptor signaling pathway CASPA; NLRC4; IL8L2; NAIP6; NFKBIAA; CXCL2; IKBKB; MAPK1; TAB2; HSP90AA1.1
    RIG-I-like receptor signaling pathway MAPK8B; IL12B; MAPK12; DDX3; MAPK14A; IKBKG; AZI2; ATG5; MAPK12B; IL-8
    Fc epsilon RI signaling pathway INPP5D; PLA2G4C; MAP2K2; SYK; MAPK8; VAV1; TNF; LCP2; PLA2G4A; FCER1G
    TNF signaling pathway PTGS2; FADD; CXCL10; LIF; CASP8; CCL5; CREB3L3; ICAM1; TNFRSF1B; ATF4
    Neurotrophin signaling pathway NTRK1; NTF3; CALM4; TRAF6; PIK3CA; BAD; NRAS; ATF4; SH2B3; NFKBIA
    Retrograde endocannabinoid signaling GABRG3; MAPK10; MAPK9; ITPR1; PLCB2; DAGLB; GNB4; GNG12; GNAI1; GABRA4
    Dopaminergic synapse GNG7; PPP1CA; PPP1CB; DRD5; KIF5B; PPP2R5C; AKT2; PLCB2; GNAI1; GRIA1
    Inflammatory mediator regulation of TRP channels MAPK11; PLA2G4F; CYP4A10; CAMK2G; PTGER2; SRC; PRKCB; PIK3R2; CALML5; PRKCD
    Insulin signaling pathway TSC1; MAP2K2B; INPP5K; FOXO1A; GYS2; PYGM; SOCS2; MAPK3; HK3; PTPRFB
    GnRH signaling pathway MAPK14A; RAF1; GNAQ; LHB; PLD1; MAP2K6; PRKACBA; PRKACAA; CALM1; MAP2K2
    Progesterone-mediated oocyte maturation RAF1B; CDC25B; MAPK8; PIK3R2; ADCY2B; PIK3CD; MAPK12; INS2; CDC16; CPEB4
    Prolactin signaling pathway CSH; MAP2K1; SOCS7; PIK3R5; LHCGR; NEK3; MAPK12; CCND1; NRAS; INS
    Adipocytokine signaling pathway NFKB1; ADIPOQB; NFKBIA; AKT3A; PRKCQ; RXRGA; LEPB; PPARA; NFKBIAA; CAMKK2
    Type II diabetes mellitus IKBKB; CACNA1G; PRKCE; HKDC1; INS-IGF2; IRS2; IRS4; SOCS3; PIK3CB; PIK3R1
    Insulin resistance INSB; PIK3R3; CREB3L3L; RELA; SLC27A3; PTENB; OGT.1; IKBKB; AKT2; PRKAG2A
    Non-alcoholic fatty liver disease (NAFLD) UQCRFS1; SOCS3; UQCRB; MAP3K11; COX4I2; NR1H3; IRS1; NDUFS2; PRKAB1; NDUFB10
    Epithelial cell signaling in Helicobacter pylori infection TCIRG1; ATP6V1G1; F11R; PAK1; ATP6AP1; NOD1; MAP3K14; MAP2K4; LYN; RELA
    Shigellosis U2AF1; HCLS1; ITGB1; PFN2; MAPK13; PFN3; MAPK1; FBXW11; WAS; WASF1
    Salmonella infection IL1A; ARPC4L; KLC4; CXCL2; CXCL8B.3; CASPA; IL1B; ACTG1; TLR5; RILP
    Pertussis Il23a; IRF1; ITGB1; C1QB; TICAM2; IL-8; MAPK3; ITGAM; C1QC; C1RA
    Chagas disease (American trypanosomiasis) GNAS; GNA11; TNF; PPP2R2A; IFNGR2; GNAI2; TGFB1; C1QA; TLR9; NFKBIA
    Toxoplasmosis TYK2; HLA-DQA1; GNAI2; IFNGR2; HLA-DRA; IRAK1; H2-AA; IFNG; HLA-DQA2; PDPK1
    Tuberculosis APAF1; CD14; ATP6V0D2; TLR4; Cd209g; FCGR2A; ATP6V0A4; ATP6V1H; BCL10; HLA-DRB1
    Hepatitis C PPP2CB; EIF2AK4; MAPK13; CLDN16; NR1H3; TRAF2; OAS3; PIK3R1; RAF1; IRF9
    Hepatitis B DDX3X; CASP9; TGFB2; PIK3R5; PIK3CD; MAP3K1; TLR3; TGFB3; CASP8; BIRC5
    Herpes simplex infection Ccl12; SRSF7; CDC34; CUL1; THOC4; PVRL1B; EEF1DA; SRSF4; TAF5; BF1
    Epstein-Barr virus infection RBPJ; NCOR2; CCNA2; HDAC4; TRAF1; MAP2K6; HDAC1; HLA-C; PSMD8; PSMC5
    Pathways in cancer LPAR6; FZD3; FGF4; ARNT2; CCNE2; GNB1; PML; PTGER4; TRAF5; LAMC1
    Colorectal cancer PIK3R1; RAC2; TCF7L2; MSH6; RAC1; FOS; AXIN2; MAP2K1; TGFB2; TCF7
    Pancreatic cancer TGFBR2; TP53; AKT1; PIK3CA; RAC3; MAPK3; RB1; AKT2; SMAD2; ARHGEF6
    Choline metabolism in cancer PLA2G4B; DGKB; PDGFD; Pdgfa&Pdgfb; PLA2G4F; PDGFB; PCYT1A; PDGFC; PIP5K1A; PLCG1

    MAPK10 has several biochemical functions, for example, ATP binding, JUN kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK10 itself. We selected most functions MAPK10 had, and list some proteins which have the same functions with MAPK10. You can find most of the proteins on our site.

    Function Related Protein
    JUN kinase activity MAPK8; MAPK10; MAPK9; ALPK2
    MAP kinase kinase activity PAK3; LRRK2; MAPK10; MAP3K14; MAP2K7; MAP2K1; MAP2K2A; MAP2K2B; MAPK14; MAP2K2
    protein binding NIPAL1; LLGL2; RTN4RL1B; LTF; OCA2; CEP350; IL1RAPL1; SND1; PXMP4; APOA1

    MAPK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK10.

    ARRB1; JUN; HAX1; RELA; ARRB2; CEP290; GTF3C1; UNC119; TNIP1; CREBBP; PLIN2; KIF26A; linkable pd173955 analogue; gefitinib; WDR62

    Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
    Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).

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