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MAPK10

  • Official Full Name

    mitogen-activated protein kinase 10

  • Overview

    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms

    MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • S.frugiperda
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPK10-27604TH Recombinant Human MAPK10 E.coli N/A
Human MAPK10-239H Recombinant Human MAPK10 protein, His-tagged E.coli His
Human MAPK10-339H Recombinant Human MAPK10, GST-tagged, Active Sf9 Insect Cell GST
Human MAPK10-752H Recombinant Human Mitogen-activated Protein Kinase 10 E.coli N/A
Human MAPK10-27605TH Recombinant Human MAPK10 N/A
Human MAPK10-1044H Recombinant Human Mitogen-Activated Protein Kinase 10, GST-tagged E.coli GST
Human MAPK10-691H Recombinant Human Mitogen-activated Protein Kinase 10, GST-His S.frugiperda His/GST
Human MAPK10-154H Recombinant Human MAPK10 protein, His/MBP-tagged E.coli His/MBP 21-110 aa
Human MAPK10-4497HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
Human MAPK10-4499HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
Human MAPK10-4498HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
Human MAPK10-3584H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPK10-4539H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPK10-2784H Recombinant Human MAPK10 protein, His-tagged E.coli His 271-408 aa
Human MAPK10-01H Recombinant Human MAPK10 protein, His-tagged Insect Cell His 1-464aa
Human MAPK10-4998H Recombinant Human MAPK10 Protein (Arg88-Ala332), N-His tagged E.coli N-His Arg88-Ala332
Human MAPK10-8439HF Active Recombinant Full Length Human MAPK10 Protein, GST-tagged E.coli GST 1-426
Human MAPK10-1141H Recombinant Human MAPK10 Protein (M1-S423), His tagged E.coli His M1-S423
Human MAPK10-1140H Recombinant Human MAPK10 Protein (M1-S423), Tag Free E.coli No tag M1-S423
Mouse Mapk10-3938M Recombinant Mouse Mapk10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque MAPK10-2671R Recombinant Rhesus monkey MAPK10 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MAPK10-2491R Recombinant Rhesus Macaque MAPK10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MAPK10-2491R-B Recombinant Rhesus Macaque MAPK10 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAPK10-3593Z Recombinant Zebrafish MAPK10 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAPK10 Related Articles
  • MAPK10 Related Research Area
  • MAPK10 Related Signal Pathway

MAPK10 involved in several pathways and played different roles in them. We selected most pathways MAPK10 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCACNA1G;RAC3;PLA2G4A;PLA2G4F;PPP3CA;MAP2K2A;FGF10A;CACNG2A;CACNA1B
ErbB signaling pathwayPAK4;ERBB4;CBLB;BADB;PRKCA;MAP2K2A;NCK1;NRAS;SHC2
Ras signaling pathwayPIK3CG;PAK1;KSR1;RASA3;KIT;FLT1;SHC3;MAPK9;MRAS
cAMP signaling pathwayCAMK4;HTR1B;PRKACB;RAC3;RYR2;F2R;CAMK2G;ATP1A3;GLI1
FoxO signaling pathwayARAF;AKT2L;MAPK1;MAPK8A;PIK3R3A;PRKAG1;PIK3CA;TGFB1;Fasl
Sphingolipid signaling pathwayHRAS;S1PR5;GNAI3;PIK3CB;ASAH2;SPHK2;RHOA;PIK3R3;NRAS
Protein processing in endoplasmic reticulumPDIA6;UFD1L;DNAJB12A;HSP26;CRYABA;SEC61G;CAPN2L;VCP;UBE2G1B
Wnt signaling pathwayBAMBIA;APC;GSK3AA;PRKACBB;FOSL1;CAMK2G1;DKK1B;GPC4;NLK2
Osteoclast differentiationMAPK13;MITF;FCGR4;LILRB2;SOCS3;TEC;ITGB3;TYROBP;MAPK8
Focal adhesionSOS1;CAPN2;ITGA3B;BIRC2;EGFRA;LAMB3;HGF;PAK7;MYL5
Toll-like receptor signaling pathwayCD86;AKT2L;IRF5;TMED7-TICAM2;MAP2K2A;IL12B;CCL4L2;TLR1LA;TLR9
NOD-like receptor signaling pathwaySGUT1;TRIP6;MAPK8A;MAPK12;CASPA;ERBB2IP;NAIP6;TAB3;NFKB1
RIG-I-like receptor signaling pathwayIFNA3;IFNA2;RNF125;IL-8;Ifna15;IFNA17;OTUD5A;IRF7;TRAF3
Fc epsilon RI signaling pathwayGAB2;TNF;MAP2K3;MAPK13;PIK3CD;PIK3R1;AKT2;LCP2;IL5
TNF signaling pathwayPIK3CB;AKT2;CXCL10;IL18R1;MAP2K6;NFKBIA;CXCL1;MAP2K3;PIK3CG
Neurotrophin signaling pathwayPIK3CD;TP53;FOXO3;CALML5;ZFP110;MAPK8;KRAS;MAPK9;CALM1
Retrograde endocannabinoid signalingGNG5;GABRA2;GABRG2;PLCB1;GABRG1;Adcy4;GNAI2;ITPR1;GNG7
Dopaminergic synapseGNB2;GNGT2;PPP1CA;GNAI2;GNG3;SLC18A2;CAMK2G;MAOB;ITPR1
Inflammatory mediator regulation of TRP channelsCYP2J6;IL1R1;ITPR1;ALOX12;PLA2G4D;CALM1;CYP2C50;ASIC4;TRPM8
Insulin signaling pathwayCALML3;PDPK1;CALML5;FLOT2;PCK2;MAPK8A;PRKAG2;G6PC;FLOT2A
GnRH signaling pathwayCAMK2G1;GNRHR2;PRKCDA;MAPK12A;PTK2BB;CALML5;MAP2K2;CACNA1SB;MMP14
Progesterone-mediated oocyte maturationCPEB2;RPS6KA3;SPDYB;AKT3A;MAPK8A;PRKACAA;RAF1B;RPS6KAL;INS
Prolactin signaling pathwayELF5;RELA;MAPK1;PIK3R5;PIK3CB;AKT2;NEK3;GRB2;TH
Adipocytokine signaling pathwayMAPK8;RXRA;STAT3;IKBKB;ACSL4;PTPN11A;AKT3A;CAMKK2;TNFRSF1A
Type II diabetes mellitusPKM;IRS1;PIK3CD;HKDC1;ADIPOQ;TNF;IRS2;SOCS2;HK1
Insulin resistancePRKCD;INSRA;INS2;PRKCQ;PTPRF;RPS6KA6;SLC27A4;PDPK1B;INSRB
Non-alcoholic fatty liver disease (NAFLD)AKT2;COX7A1;COX7B;NDUFS7;FASLG;IL1A;NDUFB6;NDUFA4;FAS
Epithelial cell signaling in Helicobacter pylori infectionMAPK8;LYN;ATP6V1E2;ATP6V0E1;MAP3K14;ATP6V1G2;ATP6V1F;PLCG2;MAP2K4
ShigellosisDIAPH1;MAPK1;U2AF1;ITGB1;PFN1;SRC;NFKBIB;ATG5;VCL
Salmonella infectionROCK2B;FLNA;FLNC;ROCK1;CDC42L2;WASF1;KLC1;DYNC1LI1;CCL3L3
PertussisC4BPB;C5;C2;PYCARD;IL23;IL-8;IRAK1;CALM3;CALM1
Chagas disease (American trypanosomiasis)PIK3CG;PLCB1;CD3E;TGFB1;GNA11;IL6;CCL3;FOS;GNAQ
ToxoplasmosisLDLR;IRGM1;TRAF6;HLA-DMB;HLA-DQB1;TLR4;HLA-DRB1;MAP2K3;IKBKB
TuberculosisRELA;HLA-DOB;BCL2;AKT2;RAB7A;IRAK2;HSPA9;HLA-DQA1;TLR1
Hepatitis CPIK3R1;IFN-a;PPP2R2B;EIF2AK3;SOS1;IRF3;PPARA;IFNA2;IFIT1
Hepatitis BIKBKG;PTEN;SMAD3;ATF4;IKBKE;TBK1;TIRAP;PRKCA;CYCS
Influenza ATYK2;PIK3R3;MAVS;IRF7;SOCS3;HSPA1B;MAP2K7;DDX58;HLA-DPA1
Herpes simplex infectionTLR2-2;CLOCK;SFRS9;MHC2DEB;SRSF2;MAPK9;SRSF7A;NFKBIAA;TRAF5
Epstein-Barr virus infectionTRADD;POLR2A;MAP3K14;NFKBIB;MAPK12;HSPB2;TBK1;MDM2;YWHAB
Pathways in cancerZBTB16;PLCB2;LAMA5;NFKB2;BAX;BMP4;HDAC2;Kitl;FGF17
Colorectal cancerPIK3CG;CYCS;MAPK1;MSH3;MLH1;TGFBR2;RAC1;PIK3R5;FOS
Pancreatic cancerSMAD2;RALGDS;TRP53;PIK3CB;CCND1;CASP9;TGFB3;PIK3CA;RAF1
Choline metabolism in cancerPIP5K1C;PLA2G4B;EGF;PLCG1;RHEB;PIK3R5;KRAS;SP1;WASF2

MAPK10 has several biochemical functions, for example, ATP binding, JUN kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK10 itself. We selected most functions MAPK10 had, and list some proteins which have the same functions with MAPK10. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP1A1A.4;ACSBG2;HSP104;MYO6;ABCG2B;YARS2;ROR2;IRAK1;CLCN3
JUN kinase activityMAPK10;MAPK9;ALPK2;MAPK8
MAP kinase kinase activityMAP2K7;PAK3;MAP2K1;MAP2K2A;MAP3K20;ALPK2;MAP3K9;MAP2K6;MAP2K2
protein bindingPOU2F3;PER2;SNAP47;KRT17;USP10;ASIC1;ATP6V1D;CCND2;B3GAT3

MAPK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK10.

ARRB1; JUN; HAX1; RELA; ARRB2; CEP290; GTF3C1; UNC119; TNIP1; CREBBP; PLIN2; KIF26A; linkable pd173955 analogue; gefitinib; WDR62

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).
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