Recombinant Human MAPK10 Protein (M1-S423), Tag Free
Cat.No. : | MAPK10-1140H |
Product Overview : | Recombinant Human JNK3(M1-S423) Protein was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock. Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1. |
Source : | E. coli |
Species : | Human |
Tag : | No tag |
Form : | Liquid |
Protein Length : | M1-S423 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | MAPK10 mitogen-activated protein kinase 10 [ Homo sapiens (human) ] |
Official Symbol : | MAPK10 |
Synonyms : | MAPK10; mitogen-activated protein kinase 10; PRKM10; JNK3; p54bSAPK; p493F12; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3; JNK3A; SAPK1b; FLJ12099; FLJ33785; MGC50974; |
Gene ID : | 5602 |
mRNA Refseq : | NM_002753 |
Protein Refseq : | NP_002744 |
MIM : | 602897 |
UniProt ID : | P53779 |
Products Types
◆ Recombinant Protein | ||
Mapk10-3938M | Recombinant Mouse Mapk10 Protein, Myc/DDK-tagged | +Inquiry |
MAPK10-2491R | Recombinant Rhesus Macaque MAPK10 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAPK10-1141H | Recombinant Human MAPK10 Protein (M1-S423), His tagged | +Inquiry |
MAPK10-2671R | Recombinant Rhesus monkey MAPK10 Protein, His-tagged | +Inquiry |
MAPK10-4998H | Recombinant Human MAPK10 Protein (Arg88-Ala332), N-His tagged | +Inquiry |
◆ Lysates | ||
MAPK10-4498HCL | Recombinant Human MAPK10 293 Cell Lysate | +Inquiry |
MAPK10-4497HCL | Recombinant Human MAPK10 293 Cell Lysate | +Inquiry |
MAPK10-4499HCL | Recombinant Human MAPK10 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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