Recombinant Human MAPK10

• Cat.No.: MAPK10-27604TH
• Product Overview: Recombinant full length protein, inactive (Human)

Specification

• Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Source: E. coli
• Tissue specificity: Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.
• Form: Liquid
• Storage buffer: Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: MAPK10 mitogen-activated protein kinase 10 [ Homo sapiens ]
• Official Symbol: MAPK10
• Synonyms: MAPK10; mitogen-activated protein kinase 10; PRKM10; JNK3; p54bSAPK; p493F12
• Gene ID: 5602
• mRNA Refseq: NM_002753
• Protein Refseq: NP_002744
• MIM: 602897
• Uniprot ID: P53779
• Chromosome Location: 4q22-q23
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Activation of the AP-1 family of transcription factors, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Apoptosis, organism-specific biosystem
• Function: ATP binding; JUN kinase activity; MAP kinase activity; MAP kinase kinase activity; nucleotide binding