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MBD3

  • Official Full Name

    methyl-CpG binding domain protein 3

  • Overview

    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
  • Synonyms

    MBD3; methyl-CpG binding domain protein 3; methyl-CpG-binding domain protein 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MBD3-7179H Recombinant Human Methyl-CpG Binding Domain Protein 3, His-tagged E.coli His 1-291aa
Human MBD3-28525TH Recombinant Human MBD3, His-tagged E.coli His
Human MBD3-223H Recombinant Human MBD3 protein, T7/His-tagged E.coli T7/His
Human MBD3-1065HCL Recombinant Human MBD3 cell lysate N/A
Rhesus Macaque MBD3-2692R Recombinant Rhesus monkey MBD3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MBD3-2512R Recombinant Rhesus Macaque MBD3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MBD3-2512R-B Recombinant Rhesus Macaque MBD3 Protein Pre-coupled Magnetic Beads HEK293
Chicken MBD3-3583C Recombinant Chicken MBD3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MBD3 Related Articles

MBD3 involved in several pathways and played different roles in them. We selected most pathways MBD3 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesCOPRS;C20orf20;GATAD2B;MORF4L1;ING5A;MTA1;RBB4L;MBD3;DPY30
Chromatin organizationMTA3;ING5;ANO9A;SUZ12;MTA2;WDR77;PHF17;TAF6L;ENY2
Gene ExpressionTXN;ZNF584;DARS;NR2F6B;LAGE3;ZNF92;ZNF471;NSUN2;GTF3AB
HDACs deacetylate histonesGATAD2AB;MBD3B;MTA1;SAP30L;SAP18;GATAD2B;MTA2;SAP30;GATAD2A
RNA Polymerase I Promoter ClearanceMBD3;CD3EAP;TAF1C;GATAD2AB;CHD4;TAF1A;CHD4A;EFCAB11;MBD3B
RNA Polymerase I TranscriptionGATAD2A;CD3EAP;MBD3B;CHD4A;CHD4;PTRFB;TAF1D;GATAD2B;MBD3
RNA Polymerase I Transcription InitiationMBD3B;GATAD2AB;MBD3;CHD4A;MTA2;UBTF;MTA1;MBD3A;CHD4
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionSNAPC3;NFIA;GTF3C5;SNAPC1;ZNF143B;GTF3AB;POU2F1B;CBX3A;CHD4

MBD3 has several biochemical functions, for example, DNA binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding, contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MBD3 itself. We selected most functions MBD3 had, and list some proteins which have the same functions with MBD3. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZSCAN4F;GM14477;PCBP2;PROX2;IRX5A;HOXC11A;ZNF136;MAPK1;LHX2A
contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA bindingACTL6A;MBD3;HDAC1;RBBP4;CHD4;SMARCC1;SMARCC2;SMARCB1;GATAD2B
contributes_to RNA polymerase II distal enhancer sequence-specific DNA bindingMBD3;RBBP4;SMARCC2;SMARCE1;GATAD2B;ACTL6A;HDAC2;HDAC1;MTA2
methyl-CpG bindingMECP2;ZBTB33;MBD3B;ZBTB4;DNMT1;MBD1;ZNF295;LRWD1;MBD1B
contributes_to nucleosomal DNA bindingSMARCA4;MTA2;HDAC1;CHD4;GATAD2B;ACTB;SMARCC2;SMARCC1;ACTL6A
protein bindingPOU3F2;UTF1;ADAMTSL5;CKS1B;DALRD3;DIAP1;MYOM1;SEMA6A;CD2BP2

MBD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD3.

HDAC1; HDAC2; GATAD2B; MTA2; MTA3

Linke, M; May, A; et al. The Impact of Ovarian Stimulation on the Expression of Candidate Reprogramming Genes in Mouse Preimplantation Embryos. CYTOGENETIC AND GENOME RESEARCH 139:71-79(2013).
Lei, W; Luo, Y; et al. Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 38:369-374(2009).
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