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Official Full Name methyl-CpG binding domain protein 3
Background DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Synonyms MBD3; methyl-CpG binding domain protein 3; methyl-CpG-binding domain protein 3;
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MBD3-1065HCL Recombinant Human MBD3 cell lysate N/A
    Human MBD3-223H Recombinant Human MBD3 protein, T7/His-tagged E.coli T7/His
    Human MBD3-28525TH Recombinant Human MBD3, His-tagged E.coli His
    Human MBD3-7179H Recombinant Human Methyl-CpG Binding Domain Protein 3, His-tagged E.coli His
    Rhesus Macaque MBD3-2692R Recombinant Rhesus monkey MBD3 Protein, His-tagged Mammalian Cell His
    Chicken MBD3-3583C Recombinant Chicken MBD3 Mammalian Cell His

    MBD3 involved in several pathways and played different roles in them. We selected most pathways MBD3 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes ING4; ANO9A; SMARCA2; KDM1A; EP400; DPY30; ARID2; KAT6A; GATAD2B; PHF21A
    Chromatin organization KDM4D; KAT7B; PRMT6; ASH2L; SETD3; SMARCD3; MBD3A; KAT7A; KDM5A; MBD3
    Gene Expression ZNF792; TNRC6B; SNAPC5; NR1I2; JUNB; ZNF556; ZNF496; GTF3C2; NELFE; ESR2B
    HDACs deacetylate histones CHD4; MTA3; MTA2; GATAD2AB; SUDS3; MBD3; SAP30L; MBD3A; MTA1; MBD3B
    RNA Polymerase I Promoter Clearance TAF1A; RRN3; GATAD2B; CHD4A; MTA1; CD3EAP; GATAD2A; MTA2; EFCAB11; UBTF
    RNA Polymerase I Transcription MBD3B; TAF1C; TAF1D; TAF1A; UBTF; CBX3; CHD4; GATAD2B; CBX3A; MTA2
    RNA Polymerase I Transcription Initiation CHD4; MTA3; MBD3; GATAD2A; GATAD2AB; UBTF; MBD3A; MBD3B; CHD4A; MTA2
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription GTF3C2; GTF3C5; NFIX; MBD3B; CHD4; BRF2; SNAPC1A; MTERF; NFIA; CBX3

    MBD3 has several biochemical functions, for example, DNA binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding, contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MBD3 itself. We selected most functions MBD3 had, and list some proteins which have the same functions with MBD3. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding GATAD2B; ACTL6A; RBBP4; SMARCE1; ACTB; SMARCB1; HDAC2; MBD3; HDAC1; SMARCC1
    contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding GATAD2B; MTA2; SMARCE1; SMARCC2; HDAC1; SMARCC1; ACTB; SMARCA4; MBD3; ACTL6A
    methyl-CpG binding LRWD1; ZBTB33; MBD3; MBD1B; MBD3L1; UHRF1; ZBTB4; DNMT1; ZNF295; MBD3A
    contributes_to nucleosomal DNA binding HDAC2; GATAD2B; SMARCA4; SMARCE1; MTA2; SMARCB1; MBD3; ACTL6A; SMARCC1; SMARCC2
    protein binding RBL1; ANKMY2; ATG12; ACACB; CSDE1; NR1D1; SRPK3; ZMAT2; MYH9; DDX39A

    MBD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD3.


    Linke, M; May, A; et al. The Impact of Ovarian Stimulation on the Expression of Candidate Reprogramming Genes in Mouse Preimplantation Embryos. CYTOGENETIC AND GENOME RESEARCH 139:71-79(2013).
    Lei, W; Luo, Y; et al. Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 38:369-374(2009).

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