mbd3
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  • Official Full Name
  • methyl-CpG binding domain protein 3
  • Background
  • DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
  • Synonyms
  • MBD3; methyl-CpG binding domain protein 3; methyl-CpG-binding domain protein 3;
Cat.#:MBD3-223HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MBD3 protein, T7/His-tagged
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Cat.#:MBD3-28525THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MBD3, His-tagged
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Cat.#:MBD3-7179HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Methyl-CpG Binding Domain Protein 3, His-tagged
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Cat.#:MBD3-2692RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MBD3 Protein, His-tagged
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Cat.#:MBD3-3583CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MBD3
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Cat.#:MBD3-1065HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MBD3 cell lysate
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Involved Pathway

MBD3 involved in several pathways and played different roles in them. We selected most pathways MBD3 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
ELP2; ATXN7L3; KAT7; SMARCD3; SETD3; PHF20B; GATAD2A; C17orf81; RBBP4; KAT8
Chromatin organization
BRPF1; ZZZ3; MORF4L2; PBRM1L; SAP30; MSL3; PADI2; SETD3; KDM5BB; RBBP4
Gene Expression
PPARAA; EIF2B1; TNPO1; ZNF75D; CTDP1; ZNF2; RARG; MED8; MED10; ZNF43
HDACs deacetylate histones
SUDS3; SAP30L; GATAD2AB; ANO9A; MBD3A; MTA3; GATAD2A; BRMS1; ARID4A; SAP18
RNA Polymerase I Promoter Clearance
EFCAB11; UBTF; CHD4A; MBD3B; GATAD2A; MBD3; MTA2; MTA3; TAF1B; EHMT2
RNA Polymerase I Transcription
MTA2; CBX3; CBX3A; MBD3A; PTRF; TAF1A; EFCAB11; MBD3; PTRFB; GATAD2B
RNA Polymerase I Transcription Initiation
GATAD2A; MBD3; MBD3A; MTA3; CHD4; GATAD2AB; RRN3; MTA1; GATAD2B; MBD3B
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
GTF3AA; PTRFB; GTF3C3; SNAPC4; NFIX; MTA3; BRF1; NFIC; SNAPC1A; GTF3AB

Protein Function

MBD3 has several biochemical functions, for example, DNA binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding, contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MBD3 itself. We selected most functions MBD3 had, and list some proteins which have the same functions with MBD3. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein FOXG1A; KCNIP3; HIST1H2B7; LHX1B; BLZF1; SOX19A; RAD51L3; MEF2CA; ESRRGB; CHD8
Function contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein SMARCE1; RBBP4; ACTB; ACTL6A; SMARCA4; HDAC2; SMARCC2; CHD4; HDAC1; SMARCB1
Function contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein MBD3; HDAC2; ACTL6A; SMARCC2; SMARCE1; GATAD2B; RBBP4; SMARCA4; ACTB; MTA2
Function methyl-CpG binding
Related Protein MBD3A; MBD3B; MECP2; UHRF1; MBD3L1; DNMT1; MBD3; LRWD1; MBD1B; ZNF295
Function contributes_to nucleosomal DNA binding
Related Protein ACTB; SMARCB1; CHD4; SMARCC1; GATAD2B; MBD3; HDAC2; MTA2; RBBP4; ACTL6A
Function protein binding
Related Protein MAPK13; MEGF6; NAALADL2; MRPS6; FERD3L; FUNDC1; PDE4C; COMT; PSMG1; SPATA24

Interacting Protein

MBD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD3.
HDAC1; HDAC2; GATAD2B; MTA2; MTA3

MBD3 Related Articles

Linke, M; May, A; et al. The Impact of Ovarian Stimulation on the Expression of Candidate Reprogramming Genes in Mouse Preimplantation Embryos. CYTOGENETIC AND GENOME RESEARCH 139:71-79(2013).
Lei, W; Luo, Y; et al. Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 38:369-374(2009).