|Official Full Name||methyl-CpG binding domain protein 3|
|Background||DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]|
|Synonyms||MBD3; methyl-CpG binding domain protein 3; methyl-CpG-binding domain protein 3;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
MBD3 involved in several pathways and played different roles in them. We selected most pathways MBD3 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Chromatin modifying enzymes||ING4; ANO9A; SMARCA2; KDM1A; EP400; DPY30; ARID2; KAT6A; GATAD2B; PHF21A|
|Chromatin organization||KDM4D; KAT7B; PRMT6; ASH2L; SETD3; SMARCD3; MBD3A; KAT7A; KDM5A; MBD3|
|Gene Expression||ZNF792; TNRC6B; SNAPC5; NR1I2; JUNB; ZNF556; ZNF496; GTF3C2; NELFE; ESR2B|
|HDACs deacetylate histones||CHD4; MTA3; MTA2; GATAD2AB; SUDS3; MBD3; SAP30L; MBD3A; MTA1; MBD3B|
|RNA Polymerase I Promoter Clearance||TAF1A; RRN3; GATAD2B; CHD4A; MTA1; CD3EAP; GATAD2A; MTA2; EFCAB11; UBTF|
|RNA Polymerase I Transcription||MBD3B; TAF1C; TAF1D; TAF1A; UBTF; CBX3; CHD4; GATAD2B; CBX3A; MTA2|
|RNA Polymerase I Transcription Initiation||CHD4; MTA3; MBD3; GATAD2A; GATAD2AB; UBTF; MBD3A; MBD3B; CHD4A; MTA2|
|RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription||GTF3C2; GTF3C5; NFIX; MBD3B; CHD4; BRF2; SNAPC1A; MTERF; NFIA; CBX3|
MBD3 has several biochemical functions, for example, DNA binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding, contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MBD3 itself. We selected most functions MBD3 had, and list some proteins which have the same functions with MBD3. You can find most of the proteins on our site.
|DNA binding||ZBED5; ETV5B; TOPORS; MAP1S; KHDRBS1; ZNF182; NUP153; SMAD5; ZMAT4; MGMT|
|contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding||GATAD2B; ACTL6A; RBBP4; SMARCE1; ACTB; SMARCB1; HDAC2; MBD3; HDAC1; SMARCC1|
|contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding||GATAD2B; MTA2; SMARCE1; SMARCC2; HDAC1; SMARCC1; ACTB; SMARCA4; MBD3; ACTL6A|
|methyl-CpG binding||LRWD1; ZBTB33; MBD3; MBD1B; MBD3L1; UHRF1; ZBTB4; DNMT1; ZNF295; MBD3A|
|contributes_to nucleosomal DNA binding||HDAC2; GATAD2B; SMARCA4; SMARCE1; MTA2; SMARCB1; MBD3; ACTL6A; SMARCC1; SMARCC2|
|protein binding||RBL1; ANKMY2; ATG12; ACACB; CSDE1; NR1D1; SRPK3; ZMAT2; MYH9; DDX39A|
MBD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD3.
HDAC1; HDAC2; GATAD2B; MTA2; MTA3