mbd4
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  • Official Full Name
  • methyl-CpG binding domain protein 4
  • Background
  • DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.
  • Synonyms
  • MBD4; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; MED1; G/T mismatch glycosylase; G/U mismatch glycosylase; methyl-CpG-binding protein MBD4; 3,N(4)-ethenocytosine glycosylase; methyl-CpG-binding endonuclease 1; mismatch-speci
Cat.#:MBD4-333HTag:His
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human MBD4 Protein, His-tagged
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Cat.#:MBD4-224HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MBD4 protein, T7/His-tagged
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Cat.#:MBD4-6259CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MBD4
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Cat.#:MBD4-403HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MBD4 lysate
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Involved Pathway

MBD4 involved in several pathways and played different roles in them. We selected most pathways MBD4 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Base excision repair
OGG1; POLE3; POLD1; APEX1; MPG; MBD4; POLE2; POLD3; UNGA; SMUG1

Protein Function

MBD4 has several biochemical functions, for example, endodeoxyribonuclease activity, protein binding, pyrimidine-specific mismatch base pair DNA N-glycosylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MBD4 itself. We selected most functions MBD4 had, and list some proteins which have the same functions with MBD4. You can find most of the proteins on our site.
Function
Related Protein
Function endodeoxyribonuclease activity
Related Protein DNASE1; APEX1; DNASE1L3; RPS3; DNASE1L2; DNASE1L3L; DNASE1L1; ZRANB3; MRE11A; APLF
Function protein binding
Related Protein HSF1; MED14; SYK; PRADC1; LCMT1; LPXN; OSBPL6; S100P; RAD52; GTPBP4
Function pyrimidine-specific mismatch base pair DNA N-glycosylase activity
Related Protein TDG; TDG.1; MBD4
Function satellite DNA binding
Related Protein MLH3; CENPB; MBD4

Interacting Protein

MBD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD4.
FADD; SUV39H1; KDM1A; TRIM27; FAS; HTT; CSNK2B; CDCA2; Prkci; Cep78

MBD4 Related Articles

Thabet, Y; Le Dantec, C; et al. Epigenetic dysregulation in salivary glands from patients with primary Sjogren's syndrome may be ascribed to infiltrating B cells. JOURNAL OF AUTOIMMUNITY 41:175-181(2013).
Linke, M; May, A; et al. The Impact of Ovarian Stimulation on the Expression of Candidate Reprogramming Genes in Mouse Preimplantation Embryos. CYTOGENETIC AND GENOME RESEARCH 139:71-79(2013).