MBD4
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Official Full Name
methyl-CpG binding domain protein 4 -
Overview
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. -
Synonyms
MBD4;methyl-CpG binding domain protein 4;methyl-CpG-binding domain protein 4;MED1;G/T mismatch glycosylase;G/U mismatch glycosylase;methyl-CpG-binding protein MBD4;3,N(4)-ethenocytosine glycosylase;methyl-CpG-binding endonuclease 1;mismatch-speci
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MBD4-224H | Recombinant Human MBD4 protein, T7/His-tagged | E.coli | Human | His&T7 |
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| MBD4-6259C | Recombinant Chicken MBD4 | Mammalian Cells | Chicken | His |
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| MBD4-403HCL | Recombinant Human MBD4 lysate | HEK293 | Human | Non |
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| MBD4-333H | Recombinant Human MBD4 Protein, His-tagged | Insect Cells | Human | His | Full L. |
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Involved Pathway
MBD4 involved in several pathways and played different roles in them. We selected most pathways MBD4 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | PNKP,PCNA,FEN1,NEIL2,LIG1,nth,TDG.1,MUTYH,POLD1,APEX2 |
Protein Function
MBD4 has several biochemical functions, for example, endodeoxyribonuclease activity,protein binding,pyrimidine-specific mismatch base pair DNA N-glycosylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MBD4 itself. We selected most functions MBD4 had, and list some proteins which have the same functions with MBD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pyrimidine-specific mismatch base pair DNA N-glycosylase activity | TDG,TDG.1 |
| satellite DNA binding | CENPB,MLH3 |
| protein binding | CHRNB2,HSPA6,ASPSCR1,CNST,VAMP5,PC,CLEC18A,U2AF2,CRCT1,FDX1L |
| endodeoxyribonuclease activity | ERCC4,APLF,DNASE1L1,ERCC5,APEX1,DNASE1L3L,DNASE1,DNASE1L3,MRE11A,RPS3 |
Interacting Protein
MBD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD4.
FADD;SUV39H1;KDM1A;TRIM27;FAS;HTT;CSNK2B;CDCA2;Prkci;Cep78
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References
- Thabet, Y; Le Dantec, C; et al. Epigenetic dysregulation in salivary glands from patients with primary Sjogren's syndrome may be ascribed to infiltrating B cells. JOURNAL OF AUTOIMMUNITY 41:175-181(2013).
- Linke, M; May, A; et al. The Impact of Ovarian Stimulation on the Expression of Candidate Reprogramming Genes in Mouse Preimplantation Embryos. CYTOGENETIC AND GENOME RESEARCH 139:71-79(2013).
