mcf2l
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  • Official Full Name
  • MCF.2 cell line derived transforming sequence-like
  • Background
  • Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene.
  • Synonyms
  • MCF2L; MCF.2 cell line derived transforming sequence-like; guanine nucleotide exchange factor DBS; ARHGEF14; DBS; KIAA0362; OST; DBLs big sister; MCF2 transforming sequence-like protein; FLJ12122
Cat.#:MCF2L-4536CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MCF2L
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Cat.#:MCF2L-1068HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MCF2L cell lysate
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Involved Pathway

MCF2L involved in several pathways and played different roles in them. We selected most pathways MCF2L participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCF2L were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell death signalling via NRAGE, NRIF and NADE
ARHGEF9; ECT2; BCL2L11; CASP2; OBSCN; FGD4; FGD4A; KALRN; ARHGEF1A; ARHGEF18A
G alpha (12/13) signalling events
FGD2; ARHGAP4; FGD4; FGD4A; ABR; TIAM2; ARHGEF9; ARHGEF17; AKAP13; PLEKHG2
GPCR downstream signaling
RXFP2; DGKQ; ADM2; PROK2; EDN1; OPN1MW2; NPFF; APLNR; RLN3; SOUL3
NRAGE signals death through JNK
NET1; ARHGEF18; FGD2; ARHGAP4; AKAP13; ARHGAP4A; AATF; FGD4A; ABR; FGD4
Neurotrophic factor-mediated Trk receptor signaling
RGS19; FAIM; MCF2L; RIT1; DYNLT1; GIPC1; RIT2
Regulation of CDC42 activity
SPATA13; DOCK9; ITSN2; ARHGAP1; ARHGEF25; DOCK6; DOCK10; BCAR3; MCF2L; DNMBP
Regulation of RhoA activity
ARHGEF10L; ARHGEF28; ARHGEF3; FARP1; OBSCN; ARHGEF25; ABR; MCF2L; ECT2; MYO9B
Rho GTPase cycle
ARHGAP17A; ARHGEF3; ARHGAP28; MCF2L; ARHGAP40; ARHGAP1; ARHGAP17B; CHN1; ARHGAP26; RHOT2

Protein Function

MCF2L has several biochemical functions, for example, 1-phosphatidylinositol binding, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCF2L itself. We selected most functions MCF2L had, and list some proteins which have the same functions with MCF2L. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol binding
Related Protein SNX9; PLEKHA2; PICALM; FRMPD2; PICALMA; EPB41; PLEKHA3; SCARB1; PICALMB; SYT1
Function Rho guanyl-nucleotide exchange factor activity
Related Protein ARHGEF1A; ITSN2B; ARHGEF19; ARHGEF25; ARHGEF11; ARHGEF28; C3A.1; ARHGEF9; ITSN2; ARHGEF7

Interacting Protein

MCF2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCF2L here. Most of them are supplied by our site. Hope this information will be useful for your research of MCF2L.
SMAD2; AIMP2; YAE1D1; RABAC1; AGO1