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MCF2L

Official Full Name

MCF.2 cell line derived transforming sequence-like
Overview

Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene.
Synonyms

MCF2L; MCF.2 cell line derived transforming sequence-like; guanine nucleotide exchange factor DBS; ARHGEF14; DBS; KIAA0362; OST; DBLs big sister; MCF2 transforming sequence-like protein; FLJ12122;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MCF2L-1068HCL	Recombinant Human MCF2L cell lysate		N/A		Inquiry
Human	MCF2L-301406H	Recombinant Human MCF2L protein, GST-tagged	E.coli	GST	Phe328-Glu591	Inquiry
Mouse	Mcf2l-3993M	Recombinant Mouse Mcf2l Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Chicken	MCF2L-4536C	Recombinant Chicken MCF2L	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MCF2L involved in several pathways and played different roles in them. We selected most pathways MCF2L participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCF2L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell death signalling via NRAGE, NRIF and NADE	ARHGEF18A;ITGB3BP;ARHGAP4A;ARHGEF3;ITSN1;OBSCN;AATF;BCL2L11;TIAM2
G alpha (12/13) signalling events	TIAM2;ARHGEF1B;OBSCN;FGD4A;GNA13B;ARHGEF1A;RHOC;ARHGEF16;DCLRE1B
GPCR downstream signaling	FGD2;OXGR1A.2;CCR8;PTHRP2;DCLRE1B;CCR3;NET1;AGTR2;SOUL4
NRAGE signals death through JNK	DCLRE1B;ARHGEF18;ARHGEF18A;ARHGAP4A;ECT2;ARHGEF1A;ARHGEF3;FGD2;MCF2L
Neurotrophic factor-mediated Trk receptor signaling	RIT2;RGS19;RIT1;MCF2L;DYNLT1;FAIM;GIPC1
Regulation of CDC42 activity	DOCK9;SPATA13;ARHGEF25;DOCK6;MCF2L;DNMBP;ITSN2;ARHGAP17;BCAR3
Regulation of RhoA activity	NET1;ECT2;ARHGEF18;ARHGEF10;ARHGEF3;ABR;AKAP13;OBSCN;MCF2L
Rho GTPase cycle	ECT2;RALBP1;GDI2;RHOT1;RHOV;PLEKHG2;STARD8;FAM13B;DLC1

MCF2L has several biochemical functions, for example, 1-phosphatidylinositol binding, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCF2L itself. We selected most functions MCF2L had, and list some proteins which have the same functions with MCF2L. You can find most of the proteins on our site.

Function	Related Protein
1-phosphatidylinositol binding	SNX10;PICALM;SCARB1;PICALMA;SCIN;FRMPD2;EEA1;CCDC167;SNAP91
Rho guanyl-nucleotide exchange factor activity	FGD6;ITSN2;PLEKHG7;ARHGEF10;ARHGEF1B;DOCK10;ARHGEF7A;ITSN1;ALS2CL

MCF2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCF2L here. Most of them are supplied by our site. Hope this information will be useful for your research of MCF2L.

SMAD2; AIMP2; YAE1D1; RABAC1; AGO1