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MCOLN2

Official Full Name

mucolipin 2
Overview

Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential;superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM;607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and;C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 (PubMed;17662026)).
Synonyms

MCOLN2; mucolipin 2; mucolipin-2; FLJ36691; TRP ML2; TRPML2; TRP-ML2;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Homo sapiens (Human)
Mouse
Mus musculus (Mouse)
Zebrafish

Source

E.coli expression system
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Mouse	MCOLN2-9645M	Recombinant Mouse MCOLN2 Protein	Mammalian Cell	His		Inquiry
Mouse	MCOLN2-5419M	Recombinant Mouse MCOLN2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	MCOLN2-5419M-B	Recombinant Mouse MCOLN2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL25089HF	Recombinant Full Length Human Mucolipin-2(Mcoln2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-566)	Inquiry
Mus musculus (Mouse)	RFL12255MF	Recombinant Full Length Mouse Mucolipin-2(Mcoln2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-566)	Inquiry
Zebrafish	MCOLN2-11367Z	Recombinant Zebrafish MCOLN2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MCOLN2 involved in several pathways and played different roles in them. We selected most pathways MCOLN2 participated on our site, such as Ion channel transport, Stimuli-sensing channels, TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCOLN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ion channel transport	ATP1A1A.2;HTR3C;ANO9;TRPM6;ANO10A;NHEDC1;ATP2B3A;ATP1A1A.4;CLCN2
Stimuli-sensing channels	WNK1;NHEDC1;TRDN;TRPM4A;WNK2;FKBP1B;MCOLN2;CLCN4;ANO7
TRP channels	TRPM1B;TRPM4A;TRPC4A;TRPM1A;TRPC5A;TRPC4;TRPC4APB;TRPM4C;TRPV3
Transmembrane transport of small molecules	TSC22D3;SLC13A1;ANO8;MRS2;SLC24A5;SLC14A1;ATP2C2;RHCGL1;SLC29A1A

MCOLN2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MCOLN2 itself. We selected most functions MCOLN2 had, and list some proteins which have the same functions with MCOLN2. You can find most of the proteins on our site.

Function	Related Protein

MCOLN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCOLN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCOLN2.