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Official Full Name mediator of DNA-damage checkpoint 1
Background The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
Synonyms MDC1; mediator of DNA-damage checkpoint 1; NFBD1; mediator of DNA damage checkpoint protein 1; nuclear factor with BRCT domains 1; mediator of DNA damage checkpoint 1; homologue to Drosophila photoreceptor protein calphotin;
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Yeast
    • Tag :
    • His
    • SUMO
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MDC1-2039H Recombinant Human MDC1 Protein (1892-2082 aa), His-tagged Yeast His
    Human MDC1-2343H Recombinant Human MDC1 Protein (1892-2082 aa), His-SUMO-tagged E.coli His/SUMO
    Rat MDC1-3626R Recombinant Rat MDC1 Protein Mammalian Cell His
    Rhesus Macaque MDC1-2709R Recombinant Rhesus monkey MDC1 Protein, His-tagged Mammalian Cell His

    MDC1 involved in several pathways and played different roles in them. We selected most pathways MDC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MDC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    MDC1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MDC1 itself. We selected most functions MDC1 had, and list some proteins which have the same functions with MDC1. You can find most of the proteins on our site.

    Function Related Protein

    MDC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDC1.

    Chowdhury, F; Johnson, PW; et al. Ex Vivo Assays of Dendritic Cell Activation and Cytokine Profiles as Predictors of In Vivo Effects in an Anti-Human CD40 Monoclonal Antibody ChiLob 7/4 Phase I Trial. CANCER IMMUNOLOGY RESEARCH 2:229-240(2014).
    Nikoueinejad, H; Amirzargar, A; et al. Dynamic Changes of Regulatory T Cell and Dendritic Cell Subsets in Stable Kidney Transplant Patients A Prospective Analysis. IRANIAN JOURNAL OF KIDNEY DISEASES 8:130-138(2014).

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