|Official Full Name||Malate Dehydrogenase|
|Background||Malate dehydrogenase (EC 126.96.36.199) (MDH) is an enzyme in the citric acid cycle that catalyzes the conversion of malate into oxaloacetate (using NAD+) and vice versa (this is a reversible reaction). Malate dehydrogenase is not to be confused with malic enzyme, which catalyzes the conversion of malate to pyruvate, producing NADPH. Malate dehydrogenase is also involved in gluconeogenesis, the synthesis of glucose from smaller molecules. Pyruvate in the mitochondria is acted upon by pyruvate carboxylase to form oxaloacetate, a citric acid cycle intermediate. In order to get the oxaloacetate out of the mitochondria, malate dehydrogenase reduces it to malate, and it then traverses the inner mitochondrial membrane. Once in the cytosol, the malate is oxidized back to oxaloacetate by cytosolic malate dehydrogenase. Finally, phosphoenol-pyruvate carboxy kinase (PEPCK) converts oxaloacetate to phosphoenol pyruvate.|
|Synonyms||Cytoplasmic malate dehydrogenase; Cytosolic malate dehydrogenase; Malate dehydrogenase 1; Malate dehydrogenase 1 NAD (soluble); Malate dehydrogenase 2; Malate dehydrogenase 2 NAD (mitochondrial); MDH 1; MDH 2; MDH; MDH1; MDH2; MDHA; MDHm; MDHs; MMDH; Mor 1; Mor 2; Mor1; MOR2; SMDH; Soluble malate dehydrogenase; Malate dehydrogenase; rMDH; EC 188.8.131.52|
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MDH involved in several pathways and played different roles in them. We selected most pathways MDH participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
MDH has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MDH itself. We selected most functions MDH had, and list some proteins which have the same functions with MDH. You can find most of the proteins on our site.
MDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDH here. Most of them are supplied by our site. Hope this information will be useful for your research of MDH.