|Official Full Name||mediator complex subunit 13|
|Background||This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]|
|Synonyms||MED13; mediator complex subunit 13; ARC250; THRAP1; DRIP250; HSPC221; TRAP240; mediator of RNA polymerase II transcription subunit 13; thyroid hormone receptor associated protein 1; thyroid hormone receptor-associated protein 1; activator-recruited cofactor 250 kDa component; thyroid hormone receptor-associated protein, 240 kDa subunit; mediator of RNA polymerase II transcription, subunit 13 homolog; vitamin D3 receptor-interacting protein complex component DRIP250; thyroid hormone receptor-associated protein complex 240 kDa component; thyroid hormone receptor-associated protein complex component TRAP240;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
MED13 involved in several pathways and played different roles in them. We selected most pathways MED13 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Thyroid hormone signaling pathway||MAP2K2; RHEB; PLCG1; PRKACG; MED30; AKT1; PLCB1; DIO3; BMP4; MAPK1|
MED13 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, receptor activity, thyroid hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED13 itself. We selected most functions MED13 had, and list some proteins which have the same functions with MED13. You can find most of the proteins on our site.
|RNA polymerase II transcription cofactor activity||MED15; MED9; MED17; CNOT2; MED18; MED21; MED13A; MED8; CRSP7; MED22|
|receptor activity||MED17; PVRL2L; RTN4R; NLGN1; NLGN4Y; CADM3; PLAUR; NLGN4B; LDLR; KRT1|
|thyroid hormone receptor binding||MED30; MED13; NR0B2; MED17; NCOA3; NCOR1; HMGN3; TRIP12; MED4; MED12|
|transcription coactivator activity||CDK7; MLL5; CEBPA; MED7; NR1I3; SP4; CCAR1; PRMT2; GMEB1; APEX1|
|transcription cofactor activity||MAP3K7; ZFP710; ZFP865; MAX; MED12; NRG1; MED14; HES6; PSMC5; MED1|
MED13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED13.
Tfcp2l1; Tada2a; Kat2a