MED15 Protein, mediator complex subunit 15

MED15

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MED15

Official Full Name mediator complex subunit 15
Background The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms MED15; mediator complex subunit 15; PC2 (positive cofactor 2, multiprotein complex) glutamine/Q rich associated protein , PCQAP, TNRC7, trinucleotide repeat containing 7; mediator of RNA polymerase II transcription subunit 15; Arc105; CAG7A; TIG 1; Activator-recruited cofactor 105 kDa component; CTG repeat protein 7a; CTG7A; PC2 glutamine/Q-rich-associated protein; Positive cofactor 2 glutamine/Q-rich-associated protein; TIG-1; TIG1; TPA-inducible gene 1 protein; OTTHUMP00000198544; OTTHUMP00000198545; OTTHUMP00000198546; OTTHUMP00000198567; TPA inducible gene-1; TPA inducible protein; trinucleotide repeat containin; PCQAP; TNRC7
    • Species :
    • Human
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED15-4392HCL Recombinant Human MED15 293 Cell Lysate HEK293 N/A
    Human MED15-4478H Recombinant Human MED15 Protein, GST-tagged Wheat Germ GST
    Zebrafish MED15-12302Z Recombinant Zebrafish MED15 Mammalian Cell His

    MED15 involved in several pathways and played different roles in them. We selected most pathways MED15 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology SPRED1; LAMTOR2; MED19; COL4A4; DUSP2; ARPC5; GFRA4; MYF6; ACTR3; MED21
    Fatty acid, triacylglycerol, and ketone body metabolism MED10; PPARGC1B; APOA5; TIAM2; MED6; ACOT6; CYP7A1; CPT1B; G0S2; MED19
    Gene Expression EIF2B1; ESR2A; ZNF485; MED20; ZNF747; TP53RK; ESRRG; COBRA1; SNAPC2; DNAJC8
    Generic Transcription Pathway ZNF625; SCO1; ZNF10; PSTPIP2; ZNF701; MED10; LAMTOR1; ESRRG; ZNF426; ZNF571
    Metabolism NUDT3; TPMT.2; GGTLC1; GLYAT; ACY3.1; NUDT10; ARSI; SLC27A5; AQP1A.1; AZIN1B
    Metabolism of lipids and lipoproteins NEU4; PNPLA8; ANKRD1; ACOT10; PPARGC1B; ACOT9.2; PPM1L; NFYAL; CPNE7; CYP46A1
    PPARA activates gene expression MED25; MED31; MED21; PLIN2; MED18; MED26; ANKRD1; MED8; TIAM2; MED20
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) MED19; MED21; MED7; MED6; MED18; PLIN2; MED23; MED9; MED22; MED26

    MED15 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED15 itself. We selected most functions MED15 had, and list some proteins which have the same functions with MED15. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription cofactor activity NKX2; PPARGC1B; MED20; MED21; MED13A; MED4; MED13L; PPRC1; MED30; MED10
    protein binding SLC22A5; TFPT; TCF25; BLOC1S3; ZNF148; TNKS2; NOL4; ITCH; GFM2; ECHS1

    MED15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED15 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED15.

    CDK8; SREBF1; MED10; CDK19; MED19; MED26

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