MED19 Protein, mediator complex subunit 19

MED19

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MED19

Official Full Name mediator complex subunit 19
Background MED19 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
Synonyms MED19; mediator complex subunit 19; LCMR1; DT2P1G7; mediator of RNA polymerase II transcription subunit 19; lung cancer metastasis-related protein 1; mediator of RNA polymerase II transcription, subunit 19 homolog;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED19-362H Recombinant Human MED19 Protein, His-tagged E.coli His
    Human MED19-4390HCL Recombinant Human MED19 293 Cell Lysate HEK293 N/A
    Human MED19-4474H Recombinant Human MED19 Protein, GST-tagged Wheat Germ GST
    Mouse MED19-9691M Recombinant Mouse MED19 Protein Mammalian Cell His

    MED19 involved in several pathways and played different roles in them. We selected most pathways MED19 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology MED19; MED10; MED26; JAK3; TCF3A; PAK4; TRPC4; AP2A1; CDK5R1B; PLXNC1
    Fatty acid, triacylglycerol, and ketone body metabolism ABCA1; ACOT12; CYP4A11; CYP7A1; MED6; MTF1; MED25; MED10; DECR1; SREBF2
    Metabolism FAM96B; SLC25A16; BCHE; CYP2D6; FIG4; CHST14; GSTO2; CYP3A7-CYP3AP1; CYP2V1; UGT1B1
    Metabolism of lipids and lipoproteins DECR1; ABHD4; CPNE6; SLC25A1; ARSI; CRAT; BCHE; CYP2Y3; SLC27A2; Agmo
    PPARA activates gene expression ANKRD1; MED7; MED19; G0S2; GRHL1; MED15; GLIPR1; MED31; MED25; CTGF
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) GLIPR1; MED7; CTGF; MED10; ANKRD1; MED21; GRHL1; MED18; MED29; MED9
    Transcriptional regulation of white adipocyte differentiation MED22; MED21; EBF1; MED9; MED19; EGR2; MED18; NR2F2; MED29; CDK19

    MED19 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED19 itself. We selected most functions MED19 had, and list some proteins which have the same functions with MED19. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription cofactor activity MED9; MED12; MDT-19; MED13B; MED13L; PPARGC1B; MED21; MED4; MED17; MED10
    protein binding MYO10; SHMT2; CENPT; EDC4; LRRC33; YY1AP1; NOD1; ENOX2; FLCN; PPM1K

    MED19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED19 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED19.

    MED10; MED29

    Wu, YM; Chang, JW; et al. Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM. EMBO JOURNAL 31:3575-3587(2012).

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