MED25 Protein, mediator complex subunit 25


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Official Full Name mediator complex subunit 25
Background This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2.
Synonyms MED25; mediator complex subunit 25; mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae); mediator of RNA polymerase II transcription subunit 25; ACID1; ARC92; DKFZp434K0512; TCBAP0758; Activator interaction domain 1 protein; Activator interaction domain-containing protein 1; Activator-recruited cofactor 92 kDa component; ARC/mediator transcriptional coactivator subunit; ARC/mediator transcriptional coactivator subunit ARC92; FLJ10193; MED25 protein; MED25_HUMAN; Mediator of RNA polymerase II transcription, subunit 25 homolog (S cerevisiae); Mediator of RNA polymerase II transcription, subunit 25 homolog (yeast); MGC70671; p78; prostate-derived protein 78 kDa; mediator of RNA polymerase II transcription, subunit 25 homolog; PTOV2; CMT2B2
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED25-4471H Recombinant Human MED25 Protein, GST-tagged Wheat Germ GST
    Human MED25-873H Recombinant Human MED25 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MED25-938H Recombinant Human MED25 Mammalian Cell His
    Mouse MED25-9697M Recombinant Mouse MED25 Protein Mammalian Cell His
    Zebrafish MED25-12783Z Recombinant Zebrafish MED25 Mammalian Cell His

    MED25 involved in several pathways and played different roles in them. We selected most pathways MED25 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology ADAM22; CLTA; EPHB4B; HIF3A; MED22; GFRA1; DPYSL5B; AP2S1; DUSP7; CFL1
    Fatty acid, triacylglycerol, and ketone body metabolism ACOT9.1; CPT1B; MED16; SIN3B; TIAM2; MED20; MED9; ACOT11; ACSF3; ACOT12
    Gene Expression ZNF287; ZNF567; WTAP; JARID2; NRBF2B; IGF2BP2; EEF1A2; SUPT16H; ESR2B; MED15
    Generic Transcription Pathway ZNF560; MED7; ZNF556; NR2F1A; COX5B; ZNF114; ZNF234; NR1H3; COX6A1; ZKSCAN1
    Metabolism AZIN2; ADA; CYP4F22; PDZD11; GPHNA; SLC25A27; TCN1; MED23; MED18; AQP1A.2
    Metabolism of lipids and lipoproteins APOEB; AKR1B15; CYP2AD3; SACM1LB; MED7; EBP; BCHE; AKR1C2; ACOT2; MTF1
    PPARA activates gene expression MED15; MED23; GRHL1; MED21; SREBF2; MED19; CDK19; MED29; MTF1; MED9
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) MED23; G0S2; MTF1; MED31; CDK19; MED29; MED16; MED15; GRHL1; MED7

    MED25 has several biochemical functions, for example, protein binding, retinoic acid receptor binding, retinoid X receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED25 itself. We selected most functions MED25 had, and list some proteins which have the same functions with MED25. You can find most of the proteins on our site.

    Function Related Protein
    protein binding MAPK12; C5orf30; FTH1; VTA1; CXXC5; RPS27; ATL2; MAP6; CDK5R1; TICAM1
    retinoic acid receptor binding PRAMEF2; RXRA; ASXL1; PRAMEF1; HMGA1-RS1; PRAMEF10; NSD1; MED1; MED25; SNW1
    retinoid X receptor binding NR1H4; MED25; HMGA1-RS1; HMGA1; NR1H2; NSD1; NCOA1; NCOR1; NR0B2; RARG
    transcription factor binding HOXA7; TWIST1; NFATC4; NR0B2A; FOSB; CSNK2B; PSMC5; NAAA; FOS; MLXIPL

    MED25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED25 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED25.

    MED10; MED19; RXRA; MED26; MED9; RARA

    Figueiredo, T; Melo, US; et al. Homozygous missense mutation in MED25 segregates with syndromic intellectual disability in a large consanguineous family. JOURNAL OF MEDICAL GENETICS 52:123-127(2015).
    Caillaud, MC; Asai, S; et al. A Downy Mildew Effector Attenuates Salicylic Acid-Triggered Immunity in Arabidopsis by Interacting with the Host Mediator Complex. PLOS BIOLOGY 11:-(2013).

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