med25
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  • Official Full Name
  • mediator complex subunit 25
  • Background
  • This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2.
  • Synonyms
  • MED25; mediator complex subunit 25; mediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae); mediator of RNA polymerase II transcription subunit 25; ACID1; ARC92; DKFZp434K0512; TCBAP0758; Activator interaction domain 1 protein; Activator interaction domain-containing protein 1; Activator-recruited cofactor 92 kDa component; ARC/mediator transcriptional coactivator subunit; ARC/mediator transcriptional coactivator subunit ARC92; FLJ10193; MED25 protein; MED25_HUMAN; Mediator of RNA polymerase II transcription, subunit 25 homolog (S cerevisiae); Mediator of RNA polymerase II transcription, subunit 25 homolog (yeast); MGC70671; p78; prostate-derived protein 78 kDa; mediator of RNA polymerase II transcription, subunit 25 homolog; PTOV2; CMT2B2
Cat.#:MED25-4471HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MED25 Protein, GST-tagged
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Cat.#:MED25-873HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MED25 Protein, MYC/DDK-tagged
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Cat.#:MED25-938HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MED25
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Cat.#:MED25-9697MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MED25 Protein
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Cat.#:MED25-12783ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MED25
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Involved Pathway

MED25 involved in several pathways and played different roles in them. We selected most pathways MED25 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED25 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
NRP1A; SMAD3B; RHOGA; JAK3; DPYSL5A; FGF18B; COL6A2; COL4A5; COL6A1; CFC1
Fatty acid, triacylglycerol, and ketone body metabolism
CPT1B; CYP4A11; MED10; DGAT1B; GLIPR1; ACOT7; MTF1; Agmo; MED16; DECR1
Gene Expression
ZNF773; ZNF613; PAIP1; METTL14; C2orf49; NRBF2B; NR2E3; GATAD2B; QTRT1; MAEL
Generic Transcription Pathway
RARGA; ZNF549; ZNF606; ZNF70; ZNF205; ZNF707; ZNF625; CDK8; ZNF483; C7orf59
Metabolism
SACM1L; COX10; SLC5A9; CPNE1; PYGMB; PDK3B; NHLRC1; AQP1A.1; SLC25A12; GNG13A
Metabolism of lipids and lipoproteins
AKR1C2; DECR1; GLIPR1; PMVK; MED25; PITPNB; OSBP; HSD17B11; ALOX5AP; TIAM2
PPARA activates gene expression
MED8; MED9; MED10; PLIN2; CTGF; ANKRD1; MTF1; APOA5; MED21; MED16
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
MED31; MED7; PLIN2; MED9; GRHL1; MED19; MED29; MED15; G0S2; ANKRD1

Protein Function

MED25 has several biochemical functions, for example, protein binding, retinoic acid receptor binding, retinoid X receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED25 itself. We selected most functions MED25 had, and list some proteins which have the same functions with MED25. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein CASQ2; DYNC1H1; KCNE4; DNALI1; RAP1B; HFE2; MT1H; CHGB; ARID3A; PAX9
Function retinoic acid receptor binding
Related Protein AASS; PRAMEF2; ACTN4; HMGA1; CTBP2; PRAME; MED25; ASXL1; LRIF1; CNOT1
Function retinoid X receptor binding
Related Protein NSD1; NR4A2; HMGA1; RARG; NR1H4; FUS; NRIP1; NR0B2; VDR; PPARG
Function transcription factor binding
Related Protein DACT2; PER1; PRICKLE1; PPARGC1A; RELA; PARK7; HES6; CDK9; HDAC5; NCOR2

Interacting Protein

MED25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED25 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED25.
MED10; MED19; RXRA; MED26; MED9; RARA

MED25 Related Articles

Figueiredo, T; Melo, US; et al. Homozygous missense mutation in MED25 segregates with syndromic intellectual disability in a large consanguineous family. JOURNAL OF MEDICAL GENETICS 52:123-127(2015).
Caillaud, MC; Asai, S; et al. A Downy Mildew Effector Attenuates Salicylic Acid-Triggered Immunity in Arabidopsis by Interacting with the Host Mediator Complex. PLOS BIOLOGY 11:-(2013).