med6
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  • Official Full Name
  • mediator complex subunit 6
  • Background
  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
  • Synonyms
  • MED6; mediator complex subunit 6; ARC33; NY-REN-28; mediator of RNA polymerase II transcription subunit 6; CTD-2540L5.5; renal carcinoma antigen NY-REN-28; activator-recruited cofactor 33 kDa component;
Cat.#:MED6-4466HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MED6 Protein, GST-tagged
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Cat.#:MED6-841HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mediator Complex Subunit 6, T7-tagged
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Cat.#:MED6-131HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MED6 protein, T7-tagged
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Cat.#:MED6-557HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MED6 Protein, His-tagged
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Cat.#:MED6-9705MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MED6 Protein
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Cat.#:MED6-3945CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MED6
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Cat.#:MED6-316ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MED6
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Cat.#:MED6-4380HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MED6 293 Cell Lysate
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Involved Pathway

MED6 involved in several pathways and played different roles in them. We selected most pathways MED6 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
BNIP2; GFRA1; DUSP1; GPC1B; MYOG; CLTA; PEA15; COL4A4; LGI1; STX1B
Fatty acid, triacylglycerol, and ketone body metabolism
MED8; ACOT2; MTF1; ANKRD1; MED29; ACOT11B; CYP4A11; GRHL1; ACOT11A; SLC25A1A
Gene Expression
CCNT2A; MAEL; ZNF45; TET3; MTERF; ZNF460; ZNF324; DDX4; JUNB; ZNF547
Generic Transcription Pathway
CCNC; ZNF764; ZNF710; ZNF485; MED31; SKIB; COX8A; ZNF740; KRBA1; ZNF157
Metabolism
CYP11B1; CDO1; PLBD1; CYP3A7; GRX2; SLC25A14; PDK2B; CETP; SCP2B; GLRX
Metabolism of lipids and lipoproteins
LBR; INSIG1; MED22; ACOT11B; FABP12; ACAD11; MED18; FAAH2; CYP2U1; ACOT12
PPARA activates gene expression
GLIPR1; MED19; MTF1; SREBF2; MED7; MED26; MED31; MED22; GRHL1; MED25
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
MED25; MED19; GLIPR1; MED10; MED23; ANKRD1; CTGF; MED6; MED21; MED9

Protein Function

MED6 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly, protein binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED6 itself. We selected most functions MED6 had, and list some proteins which have the same functions with MED6. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly
Related Protein MED6
Function protein binding
Related Protein HIST1H4L; C5orf13; HMGCR; KAT8; STX12; PPP1R2P9; WARS; S100A7; E2F4; GPX7
Function transcription coactivator activity
Related Protein SUB1B; ZEB1; GATA4; TFDP1B; APEX1; TAF6L; MAML1; ATF6; CITED4; NR1H4
Function transcription factor binding
Related Protein PER1; NEUROD1; JUNBA; GTF2B; NLK; HDAC2; TRIB1; MSX2; SIRT1; E2F1

Interacting Protein

MED6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED6.
MED10; MED29; MED19; CDK19; MED26; CDK8

MED6 Related Articles

Ruiz, A; Pauls, E; et al. Characterization of the Influence of Mediator Complex in HIV-1 Transcription. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27665-27676(2014).
Lariviere, L; Plaschka, C; et al. Structure of the Mediator head module. NATURE 492:448-+(2012).