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MED6

  • Official Full Name

    mediator complex subunit 6

  • Overview

    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
  • Synonyms

    MED6; mediator complex subunit 6; ARC33; NY-REN-28; mediator of RNA polymerase II transcription subunit 6; CTD-2540L5.5; renal carcinoma antigen NY-REN-28; activator-recruited cofactor 33 kDa component;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MED6-841H Recombinant Human Mediator Complex Subunit 6, T7-tagged E.coli T7
Human MED6-557H Recombinant Human MED6 Protein, His-tagged E.coli His
Human MED6-131H Recombinant Human MED6 protein, T7-tagged E.coli T7
Human MED6-4380HCL Recombinant Human MED6 293 Cell Lysate HEK293 N/A
Human MED6-6251HF Recombinant Full Length Human MED6 Protein, GST-tagged In Vitro Cell Free System GST 246 amino acids
Human MED6-4466H Recombinant Human MED6 Protein, GST-tagged Wheat Germ GST
Mouse MED6-9705M Recombinant Mouse MED6 Protein Mammalian Cell His
Mouse MED6-5461M Recombinant Mouse MED6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MED6-5461M-B Recombinant Mouse MED6 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MED6-316Z Recombinant Zebrafish MED6 Mammalian Cell His
Chicken MED6-3945C Recombinant Chicken MED6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MED6 Related Articles

MED6 involved in several pathways and played different roles in them. We selected most pathways MED6 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Developmental BiologyACTR2B;GPC1B;ITGB3A;NKX2.2A;SPRED1;SPTB;JAK1;ARPC1B;SPAG9
Fatty acid, triacylglycerol, and ketone body metabolismTHEM5;TIAM2;ACOT12;MED21;MED10;YAP1;MTF1;CPT1B;ACOT9.2
Gene ExpressionMTA2;SAP30L;CSTF1;GTF3C3;GM3258;ZNF597;ELL;ZNF697;HNRNPL
Generic Transcription PathwayZKSCAN1;ZNF37A;ZNF624;NKX2;ZIM2;ZNF157;ZNF285A;COX4I1;ZNF263
MetabolismSLC5A6A;CYP2Y3;SIN3B;ACER1;UGT1B2;DAO1;TPMT.2;DGUOK;Gpc2
Metabolism of lipids and lipoproteinsSIN3B;APOC2;FABP9;FABP11B;PLIN2;DECR1;LBR;FABP11A;GRHL1
PPARA activates gene expressionG0S2;MED6;MTF1;MED9;CTGF;MED31;MED15;MED8;MED20
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)MED31;MED6;MED25;MED22;MED16;MED9;CTGF;MED10;MED15

MED6 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly, protein binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED6 itself. We selected most functions MED6 had, and list some proteins which have the same functions with MED6. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly
protein bindingCIR1;TMEM59;KRT4;TMEM67;CTH;PMP22;DLG3;PHLDA1;APBB3
transcription coactivator activityTADA3;NFKB2;NR1I2;NEUROG3;MED23;MAK;MYCBP;JUN;KLF7
transcription factor bindingPDX1;HEY2;TP53;VDRA;BRD7;MDFIC;HDAC8;TWIST1;IRF4

MED6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED6.

MED10; MED29; MED19; CDK19; MED26; CDK8

Ruiz, A; Pauls, E; et al. Characterization of the Influence of Mediator Complex in HIV-1 Transcription. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27665-27676(2014).
Lariviere, L; Plaschka, C; et al. Structure of the Mediator head module. NATURE 492:448-+(2012).
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