METAP2

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METAP2

Official Full Name methionyl aminopeptidase 2
Background This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2.
Synonyms METAP2; methionyl aminopeptidase 2; methionine aminopeptidase 2; MAP2; MNPEP; p67; Peptidase M; MAP 2; metAP 2; peptidase M 2; eIF-2-associated p67 homolog; initiation factor 2-associated 67 kDa glycoprotein; p67eIF2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Spodoptera Frugiperda
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • HA
    • His
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human METAP2-1454H Recombinant Human METAP2 Protein (2-478 aa), His-tagged Yeast His
    Human METAP2-2675H Recombinant Human METAP2 Protein (2-478 aa), His-Myc-tagged E.coli His/Myc
    Human METAP2-203H Recombinant Human METAP2 Protein, His-tagged Insect Cell His
    Human METAP2-4415H Recombinant Human METAP2 Protein, GST-tagged Wheat Germ GST
    Human METAP2-630H Recombinant Human METAP2 protein, HA-tagged Insect Cell HA
    Mouse METAP2-457MCL Recombinant Mouse METAP2 cell lysate Insect Cell N/A
    Mouse METAP2-876M Recombinant Mouse METAP2 Protein, His-tagged Insect Cell His
    Rat METAP2-3654R Recombinant Rat METAP2 Protein Mammalian Cell His
    Rhesus Macaque METAP2-2736R Recombinant Rhesus monkey METAP2 Protein, His-tagged Mammalian Cell His
    Chicken METAP2-1380C Recombinant Chicken METAP2 Mammalian Cell His
    METAP2-635H Recombinant Human METAP2, His-tagged Spodoptera Frugiperda His

    METAP2 involved in several pathways and played different roles in them. We selected most pathways METAP2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with METAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inactivation, recovery and regulation of the phototransduction cascade GUCA1E; NMT2; GNB5A; NMT1A; NMT1B; RGS9BP; RHOL; SAGB; METAP1; METAP2A
    Signal Transduction PENKB; RTKN; RSPO3; APOA4B.2; LRP12; CCK; PROKR1A; MKL1B; GDI1; RHOUA
    The phototransduction cascade CNGA1; NMT1A; SAGB; RGS9BP; METAP2; GRK7; NMT1B; PPEF1; METAP2B; METAP2A
    Visual phototransduction MYO7AA; BCO2A; RBP3; RLBP1A; STRA6; IRBP; BCO2; APOM; DHRS3A; RDH10

    METAP2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by METAP2 itself. We selected most functions METAP2 had, and list some proteins which have the same functions with METAP2. You can find most of the proteins on our site.

    Function Related Protein
    aminopeptidase activity XPNPEP2; TRHDE; METAP1D; METAP2A; NPEPL1; XPNPEP1; PHEX; PEPD; ERAP1; METAP2B
    hydrolase activity ASPG; IRGC; DESI1; PM20D1.2; DNASE2A; RTEL1; RNASEKB; CTDSPL2B; TDRD9; GZMF
    metal ion binding ACSM3; ZEB2A; SMYD2; FRAS1; GNAI2; HSCB; ZNF396; ZNF227; ZRSR2; PPP1CA
    metalloexopeptidase activity METAP1D; ERAP1; NPEPL1; METAP1; DPEP1; DPEP3; METAP2; METAP2B; DPEP2; RNPEP
    peptidase activity TMPRSS4B; PRSS40; CTSSA; HTRA1A; KLK1B8; PM20D1.2; CTSBB; HTRA2; TPP1; OVCH2
    poly(A) RNA binding RRP7A; BOP1; RBM47; UNK; OTUD4; TCP1; SNW1; TRMT2A; RPL32; ANXA7
    protein binding DPCD; SHISA3; NUP205; ARHGEF16; HMGCR; STAP1; BRD9; CYFIP2; GTF2B; ODF1

    METAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with METAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of METAP2.

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