metap2
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  • Official Full Name
  • methionyl aminopeptidase 2
  • Background
  • This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2.
  • Synonyms
  • METAP2; methionyl aminopeptidase 2; methionine aminopeptidase 2; MAP2; MNPEP; p67; Peptidase M; MAP 2; metAP 2; peptidase M 2; eIF-2-associated p67 homolog; initiation factor 2-associated 67 kDa glycoprotein; p67eIF2
Cat.#:METAP2-4415HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human METAP2 Protein, GST-tagged
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Cat.#:METAP2-203HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human METAP2 Protein, His-tagged
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Cat.#:METAP2-630HTag:HA
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human METAP2 protein, HA-tagged
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Cat.#:METAP2-876MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse METAP2 Protein, His-tagged
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Cat.#:METAP2-3654RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat METAP2 Protein
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Cat.#:METAP2-2736RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey METAP2 Protein, His-tagged
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Cat.#:METAP2-1380CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken METAP2
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Cat.#:METAP2-635HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:
Product nameRecombinant Human METAP2, His-tagged
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Cat.#:METAP2-457MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse METAP2 cell lysate
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Involved Pathway

METAP2 involved in several pathways and played different roles in them. We selected most pathways METAP2 participated on our site, such as Inactivation, recovery and regulation of the phototransduction cascade, Signal Transduction, The phototransduction cascade, which may be useful for your reference. Also, other proteins which involved in the same pathway with METAP2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inactivation, recovery and regulation of the phototransduction cascade
SAGB; GNB5A; RHOL; RLN1; NMT1A; METAP2A; RGS9BP; PPEF1; CNGA1; GRK7
Signal Transduction
CCK; RNF31; RGS9BP; SST1.1; NPFF; PTHRP2; ASH2L; DHRS4; OTUD7B; CLIP3
The phototransduction cascade
GUCA1E; METAP2B; METAP1; RLN1; CNGA1; NMT1A; NMT1B; METAP2A; GRK7; PPEF1
Visual phototransduction
RDH12; APOA4A; DHRS3; RPE65A; DHRS3A; RLN1; RPE65B; MYO7AA; RLBP1B; METAP2A

Protein Function

METAP2 has several biochemical functions, for example, aminopeptidase activity, hydrolase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by METAP2 itself. We selected most functions METAP2 had, and list some proteins which have the same functions with METAP2. You can find most of the proteins on our site.
Function
Related Protein
Function aminopeptidase activity
Related Protein TRHDE; Npepo; LNPEP; DNPEP; PHEX; CTSL2; ERAP1; ERAP2; METAP1D; RNPEP
Function hydrolase activity
Related Protein ABCB4; DHX33; ADAMTS12; DDX19; CAPN12; LACTB; MPPED2A; PM20D1.1; PLA2G2F; USPL1
Function metal ion binding
Related Protein NSF; MGAT1; ZFR; CAHZ; PHYH; MOCS3; MGAT4B; ACSM3; ZDHHC16; ATP1A1B
Function metalloexopeptidase activity
Related Protein NUDT16; METAP2B; METAP1D; NPEPL1; RNPEP; DPEP3; METAP2; DPEP1; DPEP2; ERAP1
Function peptidase activity
Related Protein HTRA2; REN2; DESI2; IHHB; MMP13A; MMP25; Shh; Casp3; CTRC; PGCP
Function poly(A) RNA binding
Related Protein SLTM; FUBP3; HIST1H1C; ZMAT3; RPS7; ZC3HAV1; STAU2; EMG1; EIF4G1; TUFM
Function protein binding
Related Protein TBL1X; LAX1; ZCCHC13; BCLAF1; SSBP1; VPS11; GTF3C3; PRMT3; GAS2L3; BIRC3