Recombinant Human METAP2 Protein (2-478 aa), His-Myc-tagged
Cat.No. : | METAP2-2675H |
Product Overview : | Recombinant Human METAP2 Protein (2-478 aa) is produced by E. coli expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Research Area: Metabolism. Protein Description: Full Length of Mature Protein. |
- Specification
- Gene Information
- Related Products
Description : | Cotranslationally roves the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
Source : | E. coli |
Species : | Human |
Tag : | His-Myc |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 59.8 kDa |
Protein length : | 2-478 aa |
AA Sequence : | AGVEEVAASGSHLNGDLDPDDREEG AASTAEEAAKKKRRKKKKSKGPSAA GEQEPDKESGASVDEVARQLERSAL EDKERDEDDEDGDGDGDGATGKKKK KKKKKRGPKVQTDPPSVPICDLYPN GVFPKGQECEYPPTQDGRTAAWRTT SEEKKALDQASEEIWNDFREAAEAH RQVRKYVMSWIKPGMTMIEICEKLE DCSRKLIKENGLNAGLAFPTGCSLN NCAAHYTPNAGDTTVLQYDDICKID FGTHISGRIIDCAFTVTFNPKYDTL LKAVKDATNTGIKCAGIDVRLCDVG EAIQEVMESYEVEIDGKTYQVKPIR NLNGHSIGQYRIHAGKTVPIVKGGE ATRMEEGEVYAIETFGSTGKGVVHD DMECSHYMKNFDVGHVPIRLPRTKH LLNVINENFGTLAFCRRWLDRLGES KYLMALKNLCDLGIVDPYPPLCDIK GSYTAQFEHTILLRPTCKEVVSRGD DY |
Purity : | > 85% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA will be sent along with the products. Please refer to it for detailed information. |
Gene Name : | METAP2 methionyl aminopeptidase 2 [ Homo sapiens ] |
Official Symbol : | METAP2 |
Synonyms : | METAP2; methionyl aminopeptidase 2; methionine aminopeptidase 2; MAP2; MNPEP; p67; Peptidase M; MAP 2; metAP 2; peptidase M 2; |
Gene ID : | 10988 |
mRNA Refseq : | NM_006838 |
Protein Refseq : | NP_006829 |
MIM : | 601870 |
UniProt ID : | P50579 |
Products Types
◆ Recombinant Protein | ||
METAP2-1454H | Recombinant Human METAP2 Protein (2-478 aa), His-tagged | +Inquiry |
METAP2-876M | Active Recombinant Mouse METAP2 protein(Ala2-Tyr478), His-tagged | +Inquiry |
METAP2-2780H | Recombinant Human METAP2 protein(51-190 aa), C-His-tagged | +Inquiry |
METAP2-2557R | Recombinant Rhesus Macaque METAP2 Protein, His (Fc)-Avi-tagged | +Inquiry |
METAP2-4415H | Recombinant Human METAP2 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
METAP2-457MCL | Recombinant Mouse METAP2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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