mgst2
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  • Official Full Name
  • microsomal glutathione S-transferase 2
  • Background
  • The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
  • Synonyms
  • MGST2; microsomal glutathione S-transferase 2; MGST II; FLJ27438; GST 2; GST2; MGC14097; MGST 2; MGSTII; Microsomal glutathione S transferase 2; Microsomal GST 2; Microsomal GST II; microsomal GST-2; microsomal GST-II; MGST-II
Cat.#:MGST2-5310HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MGST2 Protein, GST-tagged
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Cat.#:MGST2-693CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MGST2 Protein, His-tagged
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Cat.#:MGST2-2766RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MGST2 Protein, His-tagged
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Cat.#:MGST2-4292ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MGST2
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Cat.#:MGST2-4327HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MGST2 293 Cell Lysate
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Involved Pathway

MGST2 involved in several pathways and played different roles in them. We selected most pathways MGST2 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGST2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glutathione metabolism
GGT6; PGD; GSTM5; GPX1A; GGCT; GPX4; GSTM; SRM; GSTA3; GPX8
Metabolism of xenobiotics by cytochrome P
GSTP2; ALDH3A1; CBR3; UGT1A6B; GSTM4; MGST3; AKR7A3; UGT1AB; GSTM2; DHDH
Drug metabolism - cytochrome P
UGT2A3; UGT2B7; GSTA1; GSTM4; GSTM2; GSTP1; GSTT2B; GSTA; GSTA2; GSTAL
Chemical carcinogenesis
CYP2C55; ADH5; CYP2C50; HSD11B1; GSTM4; GSTM3; PTGS2; MGST2; CYP1A1; GSTO1

Protein Function

MGST2 has several biochemical functions, for example, enzyme activator activity, glutathione peroxidase activity, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MGST2 itself. We selected most functions MGST2 had, and list some proteins which have the same functions with MGST2. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme activator activity
Related Protein SAE1; RAB3GAP2; PRKCD; CLPSL1; ARL1; RICTOR; DBNL; DBF4; SLX4; GM749
Function glutathione peroxidase activity
Related Protein GPX1A; CLIC2; GPX8; MGST3; GRX2; MGST2; GSTT1; GPX7; GPX1B; GPX4B
Function glutathione transferase activity
Related Protein GSTA3; GSTA4; GSTM1; GSTA5; GSTM7; GSTM5; GSTT2; MGST2; EEF1G; MGST1
Function leukotriene-C4 synthase activity
Related Protein MGST2; LTC4S

MGST2 Related Articles

Weng, ZQ; Greenhaw, J; et al. Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes. TOXICOLOGY LETTERS 214:328-338(2012).
Bhattacharya, P; Keating, AF; et al. Protective role for ovarian glutathione S-transferase isoform pi during 7,12-dimethylbenz[a]anthracene-induced ovotoxicity. TOXICOLOGY AND APPLIED PHARMACOLOGY 260:201-208(2012).