MGST2
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Official Full Name
microsomal glutathione S-transferase 2
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Overview
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. -
Synonyms
MGST2; microsomal glutathione S-transferase 2; MGST II; FLJ27438; GST 2; GST2; MGC14097; MGST 2; MGSTII; Microsomal glutathione S transferase 2; Microsomal GST 2; Microsomal GST II; microsomal GST-2; microsomal GST-II; MGST-II;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Rhesus Macaque
- Zebrafish
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- MGST2 Related Articles
MGST2 involved in several pathways and played different roles in them. We selected most pathways MGST2 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGST2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | ANPEPB;GPX8;GGT1A;MGST1;GPX3;GGCTA;G6PD;GGT1;MGST3 |
| Metabolism of xenobiotics by cytochrome P | GSTO1;GSTA4;UGT2A3;GSTM3;UGT1A9;GSTT1B;MGST2;UGT1A7C;ADH1 |
| Drug metabolism - cytochrome P | UGT1A6B;MGST1.1;UGT1A6A;UGT1A4;GSTA3;AOX4;UGT2B7;AOX2P;UGT1A1 |
| Chemical carcinogenesis | UGT2A3;GSTT2B;FAM84B;UGT2A2;GSTT2;UGT1A7C;GSTA4;CCBL2;AHA-1 |
MGST2 has several biochemical functions, for example, enzyme activator activity, glutathione peroxidase activity, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MGST2 itself. We selected most functions MGST2 had, and list some proteins which have the same functions with MGST2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme activator activity | OGT;RICTOR;CTSA;DCP1B;GTF3C4;MMP24;PRKCD;RAB3GAP2;MMP16 |
| glutathione peroxidase activity | PRDX6;CLIC2;GPX8;MGST1;GPX7;MGST2;GPX4;MGST3;GPX4B |
| glutathione transferase activity | GSTT4;GSTM5;GSTT2;GRX2;GSTT1B;GSTM4;GSTT2B;EEF1E1;GSTT1 |
| leukotriene-C4 synthase activity | MGST2;LTC4S |
MGST2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGST2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MGST2.
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