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MLH1

  • Official Full Name

    mutL homolog 1

  • Overview

    This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009]
  • Synonyms

    MLH1; mutL homolog 1; FCC2; COCA2; HNPCC; hMLH1; HNPCC2; DNA mismatch repair protein Mlh1; mutL homolog 1, colon cancer, nonpolyposis type 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MLH1-233H Recombinant Human MLH1, StrepII-tagged Human Cell Strep II 410-652, 243 a.a.
Human MLH1-1306H Recombinant Human MLH1 E.coli N/A
Human MLH1-234H Recombinant Human MLH1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MLH1-4295HCL Recombinant Human MLH1 293 Cell Lysate HEK293 N/A
Human MLH1-1290H Recombinant Human MLH1 protein, His-tagged E.coli His Met1~Thr347
Human MLH1-2320H Recombinant Human MLH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MLH1-5385H Recombinant Human MLH1 Protein, GST-tagged Wheat Germ GST
Human MLH1-7335HFL Recombinant Full Length Human MLH1 protein, Flag-tagged Mamanlian cells Flag
Human MLH1-1291H Recombinant Human MLH1 protein, His-tagged E.coli His Ser486~Lys751
Human MLH1-6353HF Recombinant Full Length Human MLH1 Protein, GST-tagged In Vitro Cell Free System GST 756 amino acids
Human MLH1-4555H Recombinant Human MLH1 Protein (Gln407-Cys756), N-His tagged E.coli N-His Gln407-Cys756
Mouse MLH1-9877M Recombinant Mouse MLH1 Protein Mammalian Cell His
Mouse Mlh1-4089M Recombinant Mouse Mlh1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MLH1-5580M Recombinant Mouse MLH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MLH1-5580M-B Recombinant Mouse MLH1 Protein Pre-coupled Magnetic Beads HEK293
Rat MLH1-3701R Recombinant Rat MLH1 Protein Mammalian Cell His
Rat MLH1-3357R-B Recombinant Rat MLH1 Protein Pre-coupled Magnetic Beads HEK293
Rat MLH1-3357R Recombinant Rat MLH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MLH1-10928Z Recombinant Zebrafish MLH1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MLH1 Related Articles
  • MLH1 Related Research Area

MLH1 involved in several pathways and played different roles in them. We selected most pathways MLH1 participated on our site, such as Mismatch repair, Fanconi anemia pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Mismatch repairMSH6;RFC5;PCNA;POLD4;MSH2;EXO1;MLH1;RPA3;RFC1
Fanconi anemia pathwayAPITD1;EME1;ATRIP;RPA1;RPA4;ERCC4;TOP3A;HER9;POLK
Pathways in cancerARHGEF1;IGF1R;LAMA4;GNAQ;WNT8B;F2RL3;MAP2K2;LPAR6;PTGER1
Colorectal cancerAKT2;RHOA;BRAF;Casp3;ARAF;MSH3;PIK3CG;LEF1;TCF7L2
Endometrial cancerBAD;TCF7;HRAS;CASP9;MAPK3;MAPK1;PDPK1;AXIN2;NRAS

MLH1 has several biochemical functions, for example, ATP binding, ATPase activity, contributes_to MutSalpha complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLH1 itself. We selected most functions MLH1 had, and list some proteins which have the same functions with MLH1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAP2K2A;ABCB6;TGFBR2;NME3;RPS6KA4;PKDCCA;NLRX1;MAT2AL;ACTR8
ATPase activityDNAH11;DYNC2H1;ABCG2A;ABCA4;ATAD2B;VCP;KIFC2;ABCG2D;DYNC1H1
contributes_to MutSalpha complex bindingPMS2;MLH1
mismatched DNA bindingMSH5;PMS1;MSH6;MSH4;MLH3;MLH1;TDG
protein bindingBORA;ERCC1;TMBIM6;SMARCD1;EXOC3;UNC45B;TGIF1;SLC4A4;NRXN1
contributes_to protein bindingINTS10;TGFBR3;TAF10;MEF2A;INHA;ACVR2A;CPSF3L;MLH1;CRY1A
contributes_to single-stranded DNA bindingMSH3;POLR2D;MSH2;PMS2;MLH1;IGHM;IGJ

MLH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLH1.

PMS2; TMSB4X

Roth, RM; Hampel, H; et al. A Modified Lynch Syndrome Screening Algorithm in Colon Cancer BRAF Immunohistochemistry Is Efficacious and Cost Beneficial. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:336-343(2015).
Bettington, ML; Walker, NI; et al. A clinicopathological and molecular analysis of 200 traditional serrated adenomas. MODERN PATHOLOGY 28:414-427(2015).
  • Q&As
  • Reviews

Q&As (7)

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What is the impact of germline mutations in MLH1 on Lynch syndrome and associated cancer risks? 05/11/2022

Germline mutations in MLH1 are linked to Lynch syndrome, increasing the risk of various cancers.

What role does MLH1 play in the prevention of colorectal and other hereditary cancers? 03/25/2022

MLH1 helps prevent the development of colorectal and other hereditary cancers by maintaining DNA integrity.

How do alterations in MLH1 expression or function affect chemotherapy efficacy in cancer treatment? 12/18/2021

Changes in MLH1 function can influence the effectiveness of certain chemotherapies in treating cancer.

How does MLH1 influence the cellular response to DNA damage and the maintenance of replication fidelity? 08/14/2021

MLH1 plays a role in the cellular response to DNA damage, maintaining replication accuracy.

How does MLH1 deficiency lead to microsatellite instability in cancer cells? 04/08/2021

MLH1 deficiency results in microsatellite instability, a hallmark of certain types of cancer.

How does MLH1 (MutL Homolog 1) contribute to DNA mismatch repair and genomic stability? 07/20/2019

MLH1 is essential for DNA mismatch repair, ensuring genomic stability by correcting replication errors.

What are the mechanisms by which MLH1 modulates apoptosis in response to DNA damage? 03/31/2018

MLH1 modulates apoptosis in cells with DNA damage, preventing the proliferation of damaged cells.

Customer Reviews (3)

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Reviews
11/23/2022

    Timely protein expression optimization, greatly boosts our research.

    04/22/2022

      Accurate protein structural analysis, a cornerstone of our investigations.

      10/01/2020

        Precise antibody validation, enhances our immunoprecipitation accuracy.

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