mll1
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  • Official Full Name
  • myeloid/lymphoid or mixed-lineage leukemia 1
  • Background
  • Histone-lysine N-methyltransferase HRX is an enzyme that in humans is encoded by the MLL (ALL1) gene. MLL stands for Myeloid/Lymphoid, or Mixed-Lineage, Leukemia.
  • Synonyms
  • Mll1; myeloid/lymphoid or mixed-lineage leukemia 1; HRX; Mll; All1; ALL-1; Cxxc7; HTRX1; KMT2A; mKIAA4050; 6430520K01
Cat.#:MLL1-9881MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MLL1 Protein
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Cat.#:Kit-1781Tag:N/A
Source (Host):Species:
Product nameMLL1 Complex Chemiluminescent Assay Kit
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Cat.#:Kit-1977Tag:N/A
Source (Host):Species:
Product nameMLL1 SAM-Screener Assay Kit
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Involved Pathway

Mll1 involved in several pathways and played different roles in them. We selected most pathways Mll1 participated on our site, such as Lysine degradation, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with Mll1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Lysine degradation
PLOD1A; GLT25D1; WHSC1L1; ACAT2; SUV39H1; OGDHL; PLOD1; ALDH7A1; ALDH9A1A.1; HADH
Transcriptional misregulation in cancer
NFKBIZ; REL; NR4A3; GRIA3; CLSTN2; ITGAM; PPARG; BCL2A1A; BIRC3; HIST1H3F

Protein Function

Mll1 has several biochemical functions, for example, DNA binding, chromatin binding, core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Mll1 itself. We selected most functions Mll1 had, and list some proteins which have the same functions with Mll1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF184; SATB1A; ZFP473; ZFP512; IKZF1; HOXA13A; ZFP14; SIX2B; LIG4; SPRTN
Function chromatin binding
Related Protein NFIA; MECP2; PHC1; HOXC13; ZFP354B; BRD3; MLH3; JUN; IFT74; HMG20B
Function core promoter sequence-specific DNA binding
Related Protein SP1; TP53; NFYA; ATF4; PDX1; ESR2; NR1D1; ZFHX3; TOP1; SOX9
Function histone methyltransferase activity (H3-K4 specific)
Related Protein KMT2A; WDR82; MLL5; ASH1L; SMYD1B; WBP7; SETD3; SETMAR; KMT2E; MLL1
Function histone-lysine N-methyltransferase activity
Related Protein SUV39H1A; PRDM9; DOT1L; SMYD2A; SETD2; WBP7; EHMT1B; PRDM6; MLL5; EHMT1
Function identical protein binding
Related Protein PUF60; NPR2; ALCAMB; PKD2; ASS1; ALDH4A1; YWHAZ; SNX1; E2F7; KCNJ10
Function lysine-acetylated histone binding
Related Protein MLL1; BRDT; ATAD2B; PHIP; BRD7; BAZ2A; TAF1; PSME4B; TRIM24; BAZ1B
Function metal ion binding
Related Protein MGAT4C; KLF6A; PPARAB; SP8; Adamts19; ZNF394; PIR; CYP2X8; HPDA; OAS3
Function methyltransferase activity
Related Protein METTL17; EHMT1B; PRDM11; PMT; TYW3; CIAPIN1; WBP7; METTL18; TRMT13; GART
Function protein binding
Related Protein SND1; FAM125A; SALL4; CASP6; DDIT3; MLF1; INCA1; UBR2; PSMA7; ELL
Function protein homodimerization activity
Related Protein RAB11FIP4B; DAPK3; DARS2; GRPEL2; UBE4A; BOK; TBX18; ACVR1; MTMR2; GPD1B
Function transcription regulatory region DNA binding
Related Protein MEN1; ZFP161; TP63; KLF11; FOXC1; IKZF3; PPARG; GABPB2; ATMIN; TBL1X
Function transferase activity
Related Protein TRIO; KAT6A; PFKMB; TOMT; CKBA; EOGT; GALNTL4; ZDHHC16; TGFBR1A; B3GNT2B
Function unmethylated CpG binding
Related Protein DNMT3B; DNMT3A; KDM2A; CXXC1; MLL1
Function zinc ion binding
Related Protein TRAF4A; VDRB; NR4A2A; NR1H3; CXXC1; RBM5; PHF13; LIMCH1A; PML; RARAA

Interacting Protein

Mll1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Mll1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Mll1.
siglecg_mouse_gene; Rbbp5