mllt4
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  • Official Full Name
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
  • Background
  • This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.
  • Synonyms
  • MLLT4; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; myeloid/lymphoid or mixed lineage leukemia (trithorax (Drosophila) homolog); afadin; AF 6; AF6; protein AF-6; ALL1-fused gene from c
Cat.#:MLLT4-1011HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MLLT4, Ras-binding Domain
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Cat.#:MLLT4-29200THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MLLT4, GST-tagged
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Cat.#:MLLT4-9888MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MLLT4 Protein
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Cat.#:Mllt4-3234RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Mllt4, His-tagged
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Cat.#:MLLT4-3703RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MLLT4 Protein
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Involved Pathway

MLLT4 involved in several pathways and played different roles in them. We selected most pathways MLLT4 participated on our site, such as Ras signaling pathway, Rap signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLLT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
CALM2; ETS1; RASGRF2; GRIN2A; FGF2; INS2; GRB2; NGFR; FGF22; ARF6
Rap signaling pathway
FGFR3; FGF8; ANGPT2; RAC3; PLCB4; ITGAM; RASSF5; PRKCG; PRKD1; SIPA1L2
cAMP signaling pathway
PDE4C; PPARA; FXYD1; CREB5; NFKB1; AKT2; PIK3CD; ACOX3; HCAR2; NFKBIA
Adherens junction
ACTN1; RAC1; ACTB; PVRL1; FGFR1A; YES1; CSNK2B; PVRL3; CDC42; CSNK2A2
Tight junction
PTEN; MYH3; ACTN3B; CASK; CLDN4; CLDN7B; RAB3B; CASKB; CLDN9; CLDNE
Leukocyte transendothelial migration
RAP1B; MMP2; Itgam&Itgb2; PIK3CA; GNAI2; CLDN9; CLDN3; RAC1; ACTN1; RASSF5

Protein Function

MLLT4 has several biochemical functions, for example, Ras GTPase binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLLT4 itself. We selected most functions MLLT4 had, and list some proteins which have the same functions with MLLT4. You can find most of the proteins on our site.
Function
Related Protein
Function Ras GTPase binding
Related Protein RAP1GAP; SPHK2; MAPKAP1; MAP2K1; RASGRP3; RGL3; RAPGEF6; PLCE1; CIB1; SH3BP4
Function protein C-terminus binding
Related Protein EFHC1; HOMER3; TOP2B; VGLL1; SIRT1; NEIL1; SAE1; SDCBP2; TCF4; ITGB3BP
Function protein binding
Related Protein GMPPB; CPSF7; FCGR1A; ATP6AP2; PLD1; SEMG2; GAGE2D; UBE2K; FAIM; ZWINT

Interacting Protein

MLLT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLLT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLLT4.
SRC; PVRL3; YWHAG; PVRL2; LMO2; DBN1

MLLT4 Related Articles

Aalbers, AM; van den Heuvel-Eibrink, MM; et al. Bone marrow immunophenotyping by flow cytometry in refractory cytopenia of childhood. HAEMATOLOGICA 100:315-323(2015).
Baird, JH; Minniti, CP; et al. Oscillatory haematopoiesis in adults with sickle cell disease treated with hydroxycarbamide. BRITISH JOURNAL OF HAEMATOLOGY 168:737-746(2015).