mmaa
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  • Official Full Name
  • methylmalonic aciduria (cobalamin deficiency) cblA type
  • Background
  • The protein encoded by this gene is involved in the translocation of cobalamin into the mitochondrion, where it is used in the final steps of adenosylcobalamin synthesis. Adenosylcobalamin is a coenzyme required for the activity of methylmalonyl-CoA mutase. Defects in this gene are a cause of methylmalonic aciduria.
  • Synonyms
  • MMAA; methylmalonic aciduria (cobalamin deficiency) cblA type; methylmalonic aciduria (cobalamin deficiency) type A; methylmalonic aciduria type A protein, mitochondrial; cblA; mitochondrial; Methylmalonic aciduria type A protein; Methylmalonic aciduria type A protein mitochondrial; MGC120010; MGC120011; MGC120012; MGC120013; MMAA_HUMAN; OTTHUMP00000220105; OTTHUMP00000220104
Cat.#:MMAA-5403HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MMAA Protein, GST-tagged
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Cat.#:MMAA-573HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMAA Protein, MYC/DDK-tagged
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Cat.#:MMAA-9895MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MMAA Protein
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Cat.#:MMAA-5990ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MMAA
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Cat.#:MMAA-4286HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MMAA 293 Cell Lysate
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Involved Pathway

MMAA involved in several pathways and played different roles in them. We selected most pathways MMAA participated on our site, such as Cobalamin (Cbl, vitamin B12) transport and metabolism, Defective MMAA causes methylmalonic aciduria type cblA, Defective MUT causes methylmalonic aciduria mut type, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMAA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cobalamin (Cbl, vitamin B12) transport and metabolism
ELA2L; MTRR; LOC100686744; TCN1; CTRC; CD320; AMN; MMADHC; MMAA; ELA2
Defective MMAA causes methylmalonic aciduria type cblA
MMAA
Defective MUT causes methylmalonic aciduria mut type
MMAA
Defects in cobalamin (B12) metabolism
AMN; MTRR; MMADHC; MMAA
Defects in vitamin and cofactor metabolism
MMAA; AMN; MMADHC; MTRR
Disease
GPC5; SUPT5H; PRELP; FDXR; SUPT4H1; LRRFIP1; APOBEC3G; CPSF6; RBP4; EEF2
Diseases of metabolism
SFTPB; SFTPC; MTRR; AMN; CYP11A1; FDX1L; FDX1; EPM2A; GYG2; CCDC59
Fatty acid, triacylglycerol, and ketone body metabolism
ABCA1; AGPAT1; MED19; SLC25A1A; ACOT13; CCNC; DECR1; SIN3B; Agmo; STIL

Protein Function

MMAA has several biochemical functions, for example, GTP binding, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMAA itself. We selected most functions MMAA had, and list some proteins which have the same functions with MMAA. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein DNM2B; EIF2B2; RAB7A; RHOT1B; ARL1; RHEB; RAB17; C9orf86; ARF1L; IRGF1
Function hydrolase activity
Related Protein PPM1H; DHX36; MMP30; TMPPE; ANG4; DNASE1L3L; DDHD1; TIGARA; DUSP22A; PTPN2A

Interacting Protein

MMAA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMAA here. Most of them are supplied by our site. Hope this information will be useful for your research of MMAA.
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