mmp15
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  • Official Full Name
  • matrix metallopeptidase 15 (membrane-inserted)
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MMP15; matrix metallopeptidase 15 (membrane-inserted); MTMMP2; SMCP-2; MT2-MMP; matrix metalloproteinase-15; MMP-15; MT2MMP; MT-MMP 2; membrane-type matrix metalloproteinase 2; membrane-type-2 matrix metalloproteinase; matrix metalloproteinase 15 (membrane-inserted);
Cat.#:MMP15-607HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP15, Catalytic Domain
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Cat.#:MMP15-459HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP15 Protein, His/GST-tagged
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Cat.#:MMP15-608HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human MMP15 protein, His-tagged
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Cat.#:Mmp15-460MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mmp15 Protein, His-tagged
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Cat.#:MMP15-9910MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MMP15 Protein
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Cat.#:MMP15-4278HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MMP15 293 Cell Lysate
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Involved Pathway

MMP15 involved in several pathways and played different roles in them. We selected most pathways MMP15 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of Matrix Metalloproteinases
MMP10; MMP24; MMP13; MGC174152; CTSG; ELANE; MMP8; MMP15; TIMP2B; MGC174155
Collagen degradation
COL17A1; CTSK; MMP19; COL9A1; CTSL1; ADAM9; ADAM10; CTS7; ELANE; MMP12
Degradation of the extracellular matrix
BSG; CTSL2; TIMP2B; CTSS; BMP1B; TLDC2; MMP10; MMP15; COL13A1; MMP20
Extracellular matrix organization
COL4A3; CEACAM1; FBN1; CD151; COL9A1B; MATN3B; MMP10; MMP12; COMP; ADAMTS2
Matrix Metalloproteinases
MMP11; MMP10; MMP12; MMP25; MMP23B; MMP17; MMP28; MMP26; MMP15; MMP8

Protein Function

MMP15 has several biochemical functions, for example, calcium ion binding, enzyme activator activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP15 itself. We selected most functions MMP15 had, and list some proteins which have the same functions with MMP15. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein FSTL1A; GUCA1D; MYL12B; MFGE8A; PCDH2AB9; MASP1; IHH; CDH19; CCDC47; S100A1
Function enzyme activator activity
Related Protein DBF4; ALOX5AP; DBNL; CLPSL1; ASAP2; HSPB2; CTSA; SLX4; PRKCE; RICTOR
Function metalloendopeptidase activity
Related Protein C6AST4; ADAM30; MBTPS2; MMP13; ADAMTS16; MMEL1; MMP2; ZMPSTE24; TLL2; MMP23BB
Function protein binding
Related Protein RRAS2; pab1; CC2D1B; RPS14; NOTCH1; MYO5B; SLC8A1; INTS4; LRRIQ3; ADNP
Function zinc ion binding
Related Protein RNF113A; HE2; TRAF1; ZDHHC23; USP20; ATXN7L3; RNF128A; TXNDC17; NSMCE2; SCEL

Interacting Protein

MMP15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP15 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP15.
PROC; Gorasp2

MMP15 Related Gene Family

MMPs