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MRPL21

Official Full Name

mitochondrial ribosomal protein L21
Overview

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD).
Synonyms

MRPL21; mitochondrial ribosomal protein L21; 39S ribosomal protein L21, mitochondrial; 39S ribosomal protein L21, mitochondrial precursor; mitochondrial; 39S ribosomal protein L21; L21mt; MGC62013; MRP L21; MRP-L21; RM21_HUMAN;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MRPL21-989H	Recombinant Human MRPL21, His-tagged	E.coli	His	1-209aa	$319 / 25ug
Human	MRPL21-4188HCL	Recombinant Human MRPL21 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MRPL21-5566H	Recombinant Human MRPL21 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MRPL21-6413HF	Recombinant Full Length Human MRPL21 Protein, GST-tagged	In Vitro Cell Free System	GST	209 amino acids	Inquiry
Zebrafish	MRPL21-4742Z	Recombinant Zebrafish MRPL21	Mammalian Cell	His		Inquiry
Chicken	MRPL21-4357C	Recombinant Chicken MRPL21	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MRPL21 Related Articles

MRPL21 involved in several pathways and played different roles in them. We selected most pathways MRPL21 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ribosome	RPL13A;RPS29;RPS20;RPL3;RPSA;RPL29;RPS19;MRPL33;MRPS10

MRPL21 has several biochemical functions, for example, poly(A) RNA binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL21 itself. We selected most functions MRPL21 had, and list some proteins which have the same functions with MRPL21. You can find most of the proteins on our site.

Function	Related Protein
poly(A) RNA binding	ZCCHC11;PDCD11;LSM6;WDR36;ZNFX1;SRSF5;DDX39B;DDX52;EPPK1
structural constituent of ribosome	MRPL52;MRPL41;RPL11;RPS14;RPL13A;MRPS16;RPS29;RPL36AL;RPL22

MRPL21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL21 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL21.

Brwd3; C1qbp; ICT1; MRPL50; MRPL9; MRPL1

Ueda, M; Kadowaki, KI; et al. Gene Content and Gene Transfer from Mitochondria to the Nucleus During Evolution. MITOCHONDRIAL GENOME EVOLUTION 63:21-40(2012).

Portereiko, MF; Sandaklie-Nikolova, L; et al. Nuclear fusion defective1 encodes the Arabidopsis RPL21M protein and is required for karyogamy during female gametophyte development and fertilization. PLANT PHYSIOLOGY 141:957-965(2006).