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MRPL3

Official Full Name

mitochondrial ribosomal protein L3
Overview

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q.
Synonyms

MRPL3; mitochondrial ribosomal protein L3; RPML3; 39S ribosomal protein L3, mitochondrial; MRL3; L3mt; Mitochondrial 39S ribosomal protein L3; mitochondrial 60S ribosomal protein L3; mitochondrial ribosomal protein; MRP-L3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MRPL3-994H	Recombinant Human MRPL3, GST-tagged	E.coli	GST	1-348aa	$319 / 25ug
Human	MRPL3-4181HCL	Recombinant Human MRPL3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MRPL3-6436HF	Recombinant Full Length Human MRPL3 Protein, GST-tagged	In Vitro Cell Free System	GST	348 amino acids	Inquiry
Human	MRPL3-5573H	Recombinant Human MRPL3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	MRPL3-10058M	Recombinant Mouse MRPL3 Protein	Mammalian Cell	His		Inquiry
Mouse	MRPL3-5694M	Recombinant Mouse MRPL3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	MRPL3-5694M-B	Recombinant Mouse MRPL3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MRPL3-10368Z	Recombinant Zebrafish MRPL3	Mammalian Cell	His		Inquiry
Chicken	MRPL3-1509C	Recombinant Chicken MRPL3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MRPL3 Related Articles

MRPL3 involved in several pathways and played different roles in them. We selected most pathways MRPL3 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Mitochondrial translation	PTCD3;MRPL42;MRPL54;MRPL55;MRPL52;MRPL44;MRPL39;MRPS27;MRPS26
Mitochondrial translation elongation	MRPS25;MRPL41;MRPL51;MRPL50;MRPL37;AURKAIP1;MRPL46;PTCD3;MRPL49
Mitochondrial translation initiation	CHCHD1;MRPL28;MRPS34;MRPL39;MRPS36;MRPL41;MRPL38;MRPL47;MRPL49
Mitochondrial translation termination	CHCHD1;MRPL50;MRPL45;MRPL10;MRPL40;MRPS23;AURKAIP1;MRPS24;MRPS36
Organelle biogenesis and maintenance	PPRC1;BBS9;TSFM;DYNLRB1;ARL3;MRPS31;MRPL37;GABPA;MRPL41
Ribosome	MRPS12;MRPL14;RPL10;MRPL2;RPL7;RPL37A;RPS20;RPL41;RPSA

MRPL3 has several biochemical functions, for example, RNA binding, poly(A) RNA binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL3 itself. We selected most functions MRPL3 had, and list some proteins which have the same functions with MRPL3. You can find most of the proteins on our site.

Function	Related Protein
RNA binding	OOEP;MIF4GDA;BXDC2;TTC6;ZFP346;RCAN3;HNRNPA1;EIF1AXA;KHDRBS1A
poly(A) RNA binding	ABT1;PRRC2A;SRPR;SRP68;AATF;DNM1;HNRNPDL;GTF2E2;SMC1A
structural constituent of ribosome	RPS26L;RPS9;MRPS11;MRPS24;RPL10L;MRPL32;MRPS22;MRPL14;RPS12

MRPL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL3.

ICT1; C1qbp; Nfya; CENPA; YBX1; Bach1; Gbf1; Gpsm1; Topbp1; MRPL50; Ccdc12; NAF1; SCAF11; MRPL20; MRPL9; MRPL1; Vps28; TIMM13

Ridlon, L; Skodova, I; et al. The Importance of the 45 S Ribosomal Small Subunit-related Complex for Mitochondrial Translation in Trypanosoma brucei. JOURNAL OF BIOLOGICAL CHEMISTRY 288:32963-32978(2013).

Dzido, J; Kijewska, A; et al. Selected mitochondrial genes as species markers of the Arctic Contracaecum osculatum complex. JOURNAL OF HELMINTHOLOGY 86:252-258(2012).