MSH3 Protein, mutS homolog 3


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Official Full Name mutS homolog 3
Background The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]
Synonyms MSH3; mutS homolog 3; DUP; MRP1; DNA mismatch repair protein Msh3; hMSH3; mismatch repair protein 1; divergent upstream protein;
    • Species :
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MSH3-23HCL Recombinant Human MSH3 HEK293T cell lysate HEK293 Myc/DDK
    Human MSH3-494H Recombinant Human MSH3 protein, His-tagged E.coli His
    Zebrafish MSH3-6056Z Recombinant Zebrafish MSH3 Mammalian Cell His

    MSH3 involved in several pathways and played different roles in them. We selected most pathways MSH3 participated on our site, such as Mismatch repair, Pathways in cancer, Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mismatch repair POLD4; LIG1; RFC2; PCNA; MSH3; RPA3; MLH3; MSH6; SSBP1; POLD2
    Pathways in cancer TRAF1; STAT1; FGF9; HRAS; GNB2; WNT8B; PIK3R2; NOS2; MMP1; WNT3A
    Colorectal cancer PIK3CB; SMAD4; PIK3R3; AKT1; ARAF; MAPK10; APC2; DCC; KRAS; BAD

    MSH3 has several biochemical functions, for example, ATP binding, DNA-dependent ATPase activity, Y-form DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH3 itself. We selected most functions MSH3 had, and list some proteins which have the same functions with MSH3. You can find most of the proteins on our site.

    Function Related Protein
    DNA-dependent ATPase activity SMARCAL1; MSH2; RAD51L3; CHD8; CDK7; ERCC6; CHD6; MSH5; DHX36; SMARCA2
    Y-form DNA binding MSH3; MSH2; MEN1; WRN; RAD18
    centromeric DNA binding ZW10; MLH3; KIF2C; CENPC1; MSH3; CENPB; MSH2
    contributes_to dinucleotide insertion or deletion binding MSH2; MSH3
    contributes_to dinucleotide repeat insertion binding MSH3; MSH2
    double-strand/single-strand DNA junction binding MSH3; MSH2
    enzyme binding PEX7; HIST1H2AE; Alb; LGALS9; POLB; DHCR24; U2AF2; ANK1; EHHADH; MAPT
    NOT guanine/thymine mispair binding MSH3
    heteroduplex DNA loop binding MSH2; MSH3
    contributes_to mismatched DNA binding MSH6; MSH2; MSH3
    NOT contributes_to oxidized purine DNA binding MSH3
    protein binding CIDEB; MC3R; POLRMT; GALR2; SIP1; LGR6; CALM1; RHOT1; SPINK1; HOOK2
    NOT protein homodimerization activity MSH6; MSH3; DDIT3; EXT2; MECOM; NUDT16L1; MYO9B; MLXIPL; KCNA3
    contributes_to single guanine insertion binding MSH6; MSH2; MSH3
    contributes_to single-stranded DNA binding MSH3; POLR2D; MSH2; IGJ; IGHM; MLH1; PMS2

    MSH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH3.

    PCNA; MLH1; MSH2; RCHY1; ssdna_dn

    Muro, Y; Nakashima, R; et al. Autoantibodies to DNA Mismatch Repair Enzymes in Polymyositis/Dermatomyositis and Other Autoimmune Diseases: A Possible Marker of Favorable Prognosis. ARTHRITIS & RHEUMATOLOGY 66:3457-3462(2014).
    Tome, S; Simard, JP; et al. Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. DNA REPAIR 12:46-52(2013).

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