mxd1
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  • Official Full Name
  • MAX dimerization protein 1
  • Background
  • This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms
  • MXD1; MAX dimerization protein 1; MAD; bHLHc58; MAD1; max dimerizer 1; MAX-binding protein; antagonizer of myc transcriptional activity; MGC104659
Cat.#:MXD1-2778MTag:His|Myc
Source (Host):BaculovirusSpecies:Mouse
Product nameRecombinant Mouse MXD1 Protein (1-227 aa), His-Myc-tagged
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Cat.#:MXD1-5773HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MXD1 Protein, GST-tagged
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Cat.#:MXD1-2502HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAX Dimerization Protein 1
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Cat.#:MXD1-28856THTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MXD1, FLAG-tagged
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Cat.#:MXD1-2913RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MXD1 Protein, His-tagged
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Cat.#:MXD1-3369CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MXD1
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Cat.#:MXD1-427HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MXD1 lysate
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Involved Pathway

MXD1 involved in several pathways and played different roles in them. We selected most pathways MXD1 participated on our site, such as Regulation of Telomerase, Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with MXD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Regulation of Telomerase
CMTM2A; MXD1; NR2F2; TNKS; PINX1; SP3; DKC1
Signaling events mediated by HDAC Class I
GATA2; PRMT5; SIRT2; SIRT4; SIRT5; FKBP3; GATA1; NR2C1; SIRT7; TFCP2

Protein Function

MXD1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MXD1 itself. We selected most functions MXD1 had, and list some proteins which have the same functions with MXD1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein JUNBA; EBF1; YBX1; RBPJL; CEBPG; ETV4; ELK3; MAX; CLOCK; FEZF1
Function protein binding
Related Protein ZHX2; ACTN3; VIPR1; TMEM41A; ARL4C; UBR2; APPL1; E2F1; APBB2; CLOCKB
Function protein dimerization activity
Related Protein MYCN; MEF2D; HEY2; TFE3A; FIGLA; POLR2C; BHLHA15; TFAP2C; GGN; HNF1BA
Function transcription cofactor activity
Related Protein SLC26A3; TMF1; PRKCBP1L; MAP3K7; PSMC5; LDB2A; NFE2L1; NMI; ZNF710; NFKBIZ
Function transcription corepressor activity
Related Protein TGIF1; ZNF274; TMEM38A; SIRT6; HDAC7A; SP100; GMNN; LHX1; SSX1; MXI1
Function transcription factor activity, sequence-specific DNA binding
Related Protein YBX1; ZNF461; EGR2; PA2G4; WT1B; NKX2-5; POU3F2A; ZFP629; PRDM15; SMAD3B
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein HOXA2; RELA; PRDM5; HSF1; TCF21; GCFC2; ASCL2; ATF3; CC2D1A; HMGA2

Interacting Protein

MXD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MXD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MXD1.
SIN3B; MAX; MLX