myl3
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  • Official Full Name
  • myosin, light chain 3, alkali; ventricular, skeletal, slow
  • Background
  • MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.
  • Synonyms
  • MYL3; myosin, light chain 3, alkali; ventricular, skeletal, slow; myosin, light polypeptide 3, alkali; ventricular, skeletal, slow; myosin light chain 3; CMH8; MLC1SB; MLC1V; VLC1; CMLC1; cardiac myosin light chain 1; ventricular/slow twitch myosin alkali
Cat.#:MYL3-5809HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYL3 Protein, GST-tagged
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Cat.#:MYL3-1134HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYL3, GST-tagged
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Cat.#:MYL3-8027HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYL3 protein, His-tagged
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Cat.#:MYL3-10315MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MYL3 Protein
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Cat.#:Myl3-8028MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Myl3 protein, His & GST-tagged
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Cat.#:MYL3-3855RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MYL3 Protein
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Cat.#:MYL3-6715CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MYL3
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Cat.#:MYL3-4027HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MYL3 293 Cell Lysate
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Involved Pathway

MYL3 involved in several pathways and played different roles in them. We selected most pathways MYL3 participated on our site, such as Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with MYL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cardiac muscle contraction
CACNG3; CACNA2D3; UQCRC2A; CACNA2D1; ATP1A1A.1; COX7A2; ATP1B1; COX5A; COX6A2; CACNB2
Adrenergic signaling in cardiomyocytes
PIK3CD; PPP1CAA; CACNB2; ATP1B2A; TPM4B; ACTC1A; PPP1CA; ATP1A1B; ATP2B3B; SCN1B
Hypertrophic cardiomyopathy (HCM)
ITGA4; ITGA7; CACNG1; ITGB3; LAMA2; TPM1; EMD; CACNG6; TPM4; TPM2
Dilated cardiomyopathy
ITGA3; ITGA8; CACNB2; ACTB; ITGA1; ITGB7; ITGA5; PRKACG; SGCD; ITGB8

Protein Function

MYL3 has several biochemical functions, for example, actin monomer binding, calcium ion binding, motor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYL3 itself. We selected most functions MYL3 had, and list some proteins which have the same functions with MYL3. You can find most of the proteins on our site.
Function
Related Protein
Function actin monomer binding
Related Protein MKL1B; PFN4; TWF1; KLHL8; TMSB; MYL2; NOS3; PFN2; PKNOX2; TMSB4Y
Function calcium ion binding
Related Protein DUOX2; S100A10B; CDH8; PCDH2AB8; PCDHGA12; MMP13; EFCC1; THBS3; RASGRP2; CAPN1B
Function motor activity
Related Protein DYNC1I1; DYNLT3; DNAIC2; CGNL1; MYHZ2; VMHC; MYH7B; MYH1E; MYHZ1.2; SMYHC2
Function myosin II heavy chain binding
Related Protein MYL3; MYL4
Function structural constituent of muscle
Related Protein MYL1; MYL2; ASPH; TPM2; MYL6; SMTN; SORBS2; MYL5; MYL3; NEXN

Interacting Protein

MYL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYL3.
Mylk; FTH1; ATG101; YWHAZ