mylk2
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  • Official Full Name
  • myosin light chain kinase 2
  • Background
  • This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle.
  • Synonyms
  • MYLK2; myosin light chain kinase 2; myosin light chain kinase 2, skeletal muscle; myosin light chain kinase 2, skeletal/cardiac muscle; KMLC; MLCK2; skeletal muscle myosin light chain kinase; skMLCK; MLCK
Cat.#:MYLK2-5824HTag:GST|His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human MYLK2 Protein, GST/His-tagged
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Cat.#:MYLK2-5825HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYLK2 Protein, GST-tagged
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Cat.#:MYLK2-30269THTag:His
Source (Host):Species:Human
Product nameRecombinant Human MYLK2, His-tagged
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Cat.#:MYLK2-365HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Myosin Light Chain Kinase 2, His-tagged, Active
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Cat.#:MYLK2-8030HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYLK2 protein, His & T7-tagged
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Cat.#:Mylk2-8031MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mylk2 protein, His & T7-tagged
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Cat.#:MYLK2-3858RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MYLK2 Protein
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Cat.#:Mylk2-8032RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mylk2 protein, His & T7-tagged
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Cat.#:MYLK2-6944CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MYLK2
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Cat.#:MYLK2-1273HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Myosin Light Chain Kinase 2, GST-tagged
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Cat.#:MYLK2-1435HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MYLK2 (Active), His-tagged
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Cat.#:MYLK2-4016HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MYLK2 293 Cell Lysate
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Involved Pathway

MYLK2 involved in several pathways and played different roles in them. We selected most pathways MYLK2 participated on our site, such as Calcium signaling pathway, Focal Adhesion, Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
CACNA1B; PRKCA; ADORA2B; SLC8A2B; SLC25A4; ORAI2; PTGER1; ADRB3A; NOS2A; ADRB2A
Focal Adhesion
COL1A1B; PTEN; ITGA10; IGF1RB; PRKCB; PAK3; MYLK3; ACTN1; COL27A1B; PPP1CA
Gastric acid secretion
KCNK10; GNAI3; EZR; PLCB3; PRKACG; ATP1B2; MYLK2; CAMK2G; GNAS; ATP1A1
Integrin-mediated cell adhesion
CAPN9; CAPN11; CAPNS1; CAPN10; SEPP1A; MAPK6; CAPN3; TNS1; CAPN3A; MAPK4
Myometrial Relaxation and Contraction Pathways
PKIG; RAMP3; RXFP2; CNN1; IGFBP5; RGS19; CORIN; RGS18; CRCP; GABPA
Oxytocin signaling pathway
CACNB3; PLCB2; PRKAB1; OXT; MAP2K5; MYL6B; CACNA2D1; PIK3CD; NFATC2; MYL9
Platelet activation
P2RY1; TBXA2R; MYLK; ITPR1; PPP1R12A; PRKACA; GNAQ; LCP2; GP6; STIM1

Protein Function

MYLK2 has several biochemical functions, for example, ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYLK2 itself. We selected most functions MYLK2 had, and list some proteins which have the same functions with MYLK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PIK3C3; PLK3; XRCC5; HSPA1A; ALDH18A1; MAP3K14; NLK2; ALPK1; TGFBR1A; ANKK1
Function calmodulin binding
Related Protein CAMKK1; RYR1; CAMKK2; RGS4; MKNK2A; CAMK2D2; STRN; MAPKAPK2; PDE1C; CAMK1G
Function calmodulin-dependent protein kinase activity
Related Protein DAPK1; NETO2; DCX; CAMK2G1; CAMK2B1; CAMK2D2; CAMK2D; CAMK1GA; CAMK4; CAMK2B
Function myosin light chain kinase activity
Related Protein MYLK2; MYLK; MYLK3
Function protein binding
Related Protein CTSL1; NPHP1; RPSA; RAB4B; RNF7; ARHGAP4; POLM; METTL17; ADCYAP1R1; NAA50

Interacting Protein

MYLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYLK2.
ESR1; ESR2; MEF2C; NFKB2; HSP90AB1; TNFRSF1B; TRAF2; MAP3K1; MAP3K3; HSP90AA1

MYLK2 Related Articles

Wang, HG; Dong, JN; et al. Anti-mouse CD52 monoclonal antibody ameliorates intestinal epithelial barrier function in interleukin-10 knockout mice with spontaneous chronic colitis. IMMUNOLOGY 144:254-262(2015).
Gerarduzzi, C; He, QW; et al. Prostaglandin E-2-Dependent Blockade of Actomyosin and Stress Fibre Formation Is Mediated Through S1379 Phosphorylation of ROCK2. JOURNAL OF CELLULAR BIOCHEMISTRY 115:1516-1527(2014).