MMAA

  • Official Full Name

    methylmalonic aciduria (cobalamin deficiency) cblA type

  • Overview

    The protein encoded by this gene is involved in the translocation of cobalamin into the mitochondrion, where it is used in the final steps of adenosylcobalamin synthesis. Adenosylcobalamin is a coenzyme required for the activity of methylmalonyl-CoA mutase. Defects in this gene are a cause of methylmalonic aciduria.

  • Synonyms

    MMAA;methylmalonic aciduria (cobalamin deficiency) cblA type;methylmalonic aciduria (cobalamin deficiency) type A;methylmalonic aciduria type A protein, mitochondrial;cblA;mitochondrial;Methylmalonic aciduria type A protein;Methylmalonic aciduria type A protein mitochondrial;MGC120010;MGC120011;MGC120012;MGC120013;MMAA_HUMAN;OTTHUMP00000220105;OTTHUMP00000220104

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • HEK293
  • Mammalian Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • DDK
  • Myc
  • His
  • Non
  • GST
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
MMAA-573H Recombinant Human MMAA Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
MMAA-5990Z Recombinant Zebrafish MMAA Mammalian Cells Zebrafish His
MMAA-9895M Recombinant Mouse MMAA Protein Mammalian Cells Mouse His
MMAA-4286HCL Recombinant Human MMAA 293 Cell Lysate HEK293 Human Non
MMAA-2148H Recombinant Human MMAA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Mmaa-404M Recombinant Mouse Mmaa Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
MMAA-5403H Recombinant Human MMAA Protein, GST-tagged Wheat Germ Human GST
MMAA-5591M Recombinant Mouse MMAA Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
MMAA-5591M-B Recombinant Mouse MMAA Protein Pre-coupled Magnetic Beads HEK293 Mouse
MMAA-6384HF Recombinant Full Length Human MMAA Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 418 amino acids

    Involved Pathway

    MMAA involved in several pathways and played different roles in them. We selected most pathways MMAA participated on our site, such as Cobalamin (Cbl, vitamin B12) transport and metabolism,Defective MMAA causes methylmalonic aciduria type cblA,Defective MUT causes methylmalonic aciduria mut type, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMAA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fatty acid, triacylglycerol, and ketone body metabolism DGAT1B,MED10,ACSF2,CDK8,AGPAT1,MED25,AGPAT2,MED7,SREBF2,ACOT9
    Diseases of metabolism GYG2,FDXR,FDX1,MTRR,SFTPB,GYG1,EPM2A,AMN,MMADHC,FDX1L
    Defects in cobalamin (B12) metabolism AMN,MTRR,MMADHC
    Defects in vitamin and cofactor metabolism MMADHC,MTRR,AMN
    Cobalamin (Cbl, vitamin B12) transport and metabolism CTRC,ELA2L,CD320,MTRR,ELA2,TCN1,AMN,MMADHC,CBLC-1,CTRB1
    Disease NUP35,NMT1,SFTPB,SUPT4H1,KERA,TLR6,GCKR,TRIM24,FDXR,FGFR1OP2

    Protein Function

    MMAA has several biochemical functions, for example, GTP binding,hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMAA itself. We selected most functions MMAA had, and list some proteins which have the same functions with MMAA. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding RAB11BA,HSP90AB1,RHOU,RAB42B,HHAT,DNM1L,RABL2B,MFN1,GNAO1B,ARL5C
    hydrolase activity ATP6V0E2,C1rb,SHHB,CELL,SPACA5,Ces2c,PLCD3A,PL10,DUSP19B,RTEL1

    Interacting Protein

    MMAA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMAA here. Most of them are supplied by our site. Hope this information will be useful for your research of MMAA.

    SIRT4

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