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MMAA

Official Full Name

methylmalonic aciduria (cobalamin deficiency) cblA type
Overview

The protein encoded by this gene is involved in the translocation of cobalamin into the mitochondrion, where it is used in the final steps of adenosylcobalamin synthesis. Adenosylcobalamin is a coenzyme required for the activity of methylmalonyl-CoA mutase. Defects in this gene are a cause of methylmalonic aciduria.
Synonyms

MMAA; methylmalonic aciduria (cobalamin deficiency) cblA type; methylmalonic aciduria (cobalamin deficiency) type A; methylmalonic aciduria type A protein, mitochondrial; cblA; mitochondrial; Methylmalonic aciduria type A protein; Methylmalonic aciduria type A protein mitochondrial; MGC120010; MGC120011; MGC120012; MGC120013; MMAA_HUMAN; OTTHUMP00000220105; OTTHUMP00000220104;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
MYC
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MMAA-573H	Recombinant Human MMAA Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	MMAA-4286HCL	Recombinant Human MMAA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MMAA-2148H	Recombinant Human MMAA Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	MMAA-6384HF	Recombinant Full Length Human MMAA Protein, GST-tagged	In Vitro Cell Free System	GST	418 amino acids	Inquiry
Human	MMAA-5403H	Recombinant Human MMAA Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	MMAA-9895M	Recombinant Mouse MMAA Protein	Mammalian Cell	His		Inquiry
Mouse	MMAA-5591M	Recombinant Mouse MMAA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Mmaa-404M	Recombinant Mouse Mmaa Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Mouse	MMAA-5591M-B	Recombinant Mouse MMAA Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MMAA-5990Z	Recombinant Zebrafish MMAA	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MMAA involved in several pathways and played different roles in them. We selected most pathways MMAA participated on our site, such as Cobalamin (Cbl, vitamin B12) transport and metabolism, Defective MMAA causes methylmalonic aciduria type cblA, Defective MUT causes methylmalonic aciduria mut type, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMAA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cobalamin (Cbl, vitamin B12) transport and metabolism	AMN;LOC100686744;TCN1;ELA2L;MTRR;CD320;ELA2;CTRB1;MMAA
Defective MMAA causes methylmalonic aciduria type cblA
Defective MUT causes methylmalonic aciduria mut type
Defects in cobalamin (B12) metabolism	AMN;MMAA;MTRR;MMADHC
Defects in vitamin and cofactor metabolism	MMADHC;AMN;MTRR;MMAA
Disease	STX1B;PPIA;COBRA1;NA;PDCD6IP;DOCK2;KERA;NMT2;TIRAP
Diseases of metabolism	FDXR;GYG1;SFTPB;CCDC59;GYG2;MMADHC;MMAA;MTRR;AMN
Fatty acid, triacylglycerol, and ketone body metabolism	SREBF2;YAP1;ACOT9.2;CCNC;MED25;CYP7A1;ABCA1;MED8;MED18

MMAA has several biochemical functions, for example, GTP binding, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMAA itself. We selected most functions MMAA had, and list some proteins which have the same functions with MMAA. You can find most of the proteins on our site.

Function	Related Protein
GTP binding	RABL2A;GNAIA;SEPT4A;RHEBL1;DIRAS1A;GTPBP1L;OLA1;GUCY1A3;RABL6
hydrolase activity	MPPED1;MBLAC2;INPPL1;MPPED2;ATP1A1B;PTPN4A;CAPN2B;RPE65A;ACP5B

MMAA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMAA here. Most of them are supplied by our site. Hope this information will be useful for your research of MMAA.

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