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NAGLU

Official Full Name

N-acetylglucosaminidase, alpha
Overview

This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008]
Synonyms

NAGLU; N-acetylglucosaminidase, alpha; NAG; MPS3B; UFHSD; MPS-IIIB; alpha-N-acetylglucosaminidase; N-acetyl-alpha-glucosaminidase;

Type

Recombinant Proteins

Species

Human
Mouse
Rat

Source

CHO
E. coli
E.coli
Wheat Germ

Tag

His
His|GST
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NAGLU-27921TH	Recombinant Human NAGLU	Wheat Germ	N/A	99 amino acids	Inquiry
Human	NAGLU-1901H	Recombinant Human NAGLU, His-tagged	CHO	His		$498 / 10ug $1,998 / 50ug $3,698 / 100ug
Human	NAGLU-7905H	Recombinant Human NAGLU protein, His & T7-tagged	E.coli	His/T7	Val485~Trp743 (Accession # P54802)	Inquiry
Human	NAGLU-4658H	Recombinant Human NAGLU Protein (Val485-Trp743), N-His tagged	E.coli	N-His	Val485-Trp743	Inquiry
Human	NAGLU-705H	Recombinant Human NAGLU protein, His-tagged	E. coli	His	394-743 aa	Inquiry
Mouse	Naglu-7906M	Recombinant Mouse Naglu protein, His & GST-tagged	E.coli	His/GST	Arg429~Lys710 (Accession # O88325)	Inquiry
Mouse	NAGLU-3217M	Recombinant Mouse NAGLU protein, His-tagged	E.coli	His	Arg429~Lys710	Inquiry
Rat	Naglu-7907R	Recombinant Rat Naglu protein, His & GST-tagged	E.coli	His/GST	Asn449~Asn709 (Accession # D3ZZL3)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
NAGLU Related Articles

NAGLU involved in several pathways and played different roles in them. We selected most pathways NAGLU participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAGLU were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycosaminoglycan degradation	HYAL4;SPAM1;ARSB;HYAL3;NAGLU;GNS;HYAL2;GALNS;HYAL6
Metabolic pathways	PKLR;SDSL;GSS;UGT2A3;QDPR;SPRA;SPTLC2A;CECR1;PLD1
Lysosome	NPC1;LAPTM4B;CTPS1B;GNSB;IDS;MFSD8;GGA3;TCIRG1;ATP6V0A4

NAGLU has several biochemical functions, for example, alpha-N-acetylglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAGLU itself. We selected most functions NAGLU had, and list some proteins which have the same functions with NAGLU. You can find most of the proteins on our site.

Function	Related Protein
alpha-N-acetylglucosaminidase activity

NAGLU has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAGLU here. Most of them are supplied by our site. Hope this information will be useful for your research of NAGLU.

pi3p

Murrey, DA; Naughton, BJ; et al. Feasibility and Safety of Systemic rAAV9-hNAGLU Delivery for Treating Mucopolysaccharidosis IIIB: Toxicology, Biodistribution, and Immunological Assessments in Primates. HUMAN GENE THERAPY CLINICAL DEVELOPMENT 25:72-84(2014).

Winder-Rhodes, SE; Garcia-Reitbock, P; et al. Genetic and pathological links between Parkinson's disease and the lysosomal disorder Sanfilippo syndrome. MOVEMENT DISORDERS 27:312-315(2012).