• Official Full Name
  • NCK-associated protein 1-like
  • Background
  • This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.
  • Synonyms
  • NCKAP1L; NCK-associated protein 1-like; HEM1, hematopoietic protein 1; 4930568P13Rik; AI463083; HEM1; Hematopoietic protein 1; HEMATOPOIETIC PROTEIN HEM-1; Hemp1; Membrane associated protein hem1; Membrane-associated protein HEM-1; NCK associated protein 1 like; NCKPL_HUMAN
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NCKAP1L, GST-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NCKAP1L

Involved Pathway

NCKAP1L involved in several pathways and played different roles in them. We selected most pathways NCKAP1L participated on our site, such as Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCKAP1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Regulation of actin cytoskeleton

Protein Function

NCKAP1L has several biochemical functions, for example, GTPase activator activity, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCKAP1L itself. We selected most functions NCKAP1L had, and list some proteins which have the same functions with NCKAP1L. You can find most of the proteins on our site.
Related Protein
Function GTPase activator activity
Related Protein ARHGAP35; CDC42EP2; ARFGAP2; ARRB1; ARHGAP36; RABGAP1; ARAP1; FAM13B1; RGS19; EVI5
Function protein binding
Related Protein GABPB2; PNMA2; DRD4; CTLA4; DCTN1; EPB42; HPSE; ZBTB17; SEMA6A; PGR
Function protein complex binding
Related Protein EP300; MLC1; FYB; ITPR1; NDUFA9; BAG3; Casp3; LRP2; RPH3A; TUB
Function protein kinase activator activity
Related Protein MT3; WNT11; STRADA; PIK3CA; NCKAP1L; DAXX; MARK2; GPRC5B; CAB39; FGF13

Interacting Protein

NCKAP1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCKAP1L here. Most of them are supplied by our site. Hope this information will be useful for your research of NCKAP1L.
GAS7; 15-deoxy-delta(12,14