ndufs1
Share
  • Official Full Name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
  • Background
  • The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 1 (75kD) (NADH coenzyme Q reductase); NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; CI 75k; complex I 75kDa subunit; NADH ubiquinone oxidoreductase 75 kDa subunit; mitochondrial; Complex I 75Kd; Complex I, mitochondrial respiratory chain, 75 kD subunit; NADH coenzyme Q reductase; NADH dehydrogenase (ubiquinone) FeS protein 1 (75kD) (NADH coenzyme Q reductase); NADH ubiquinone oxidoreductase 75 kDa subunit mitochondrial; PRO1304; complex I, mitochondrial respiratory chain, 75-kD subunit; mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit; CI-75k; CI-75Kd
Cat.#:NDUFS1-1716HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDUFS1 protein, His & T7-tagged
+Inquiry
Cat.#:NDUFS1-272HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NDUFS1
+Inquiry
Cat.#:NDUFS1-10541MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NDUFS1 Protein
+Inquiry
Cat.#:NDUFS1-3942RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NDUFS1 Protein
+Inquiry
Cat.#:NDUFS1-738CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus NDUFS1 Protein, His-tagged
+Inquiry
Cat.#:NDUFS1-1656CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NDUFS1
+Inquiry
Cat.#:NDUFS1-1841ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NDUFS1
+Inquiry
Cat.#:NDUFS1-3898HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDUFS1 293 Cell Lysate
+Inquiry

Involved Pathway

NDUFS1 involved in several pathways and played different roles in them. We selected most pathways NDUFS1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
COX5AA; ATP5H; COX5A; NDUFA6; COX6B2; ATP6V0C; COX15; SDHB; ATP5D; NDUFV2
Metabolic pathways
ST3GAL2; MTMR7A; CES1C; PRODH; ASAH2; PDHA2; UOX; ACSM1; MTMR1; FUT7
Non-alcoholic fatty liver disease (NAFLD)
LEPR; TRAF2; COX7A1; BID; NDUFS1; FASLG; INS; PIK3CD; NDUFB5; IL6R
Alzheimers disease
ATP5F1; PSEN1; CYCS; COX7B; UQCRC1; CASP7; COX4I2; CALM2; CAPN1; AKR1C1
Parkinsons disease
SLC25A31; ATP5E; NDUFS4; MT-ATP6; UBE2L3; UQCRH; NDUFV1; COX8C; ATP5A1; UBE2J2
Huntingtons disease
GRIN2B; HIP1; NDUFA5; NDUFB9; NDUFA9; DNAI2; DNAH11; DNAIC2; COX8A; NDUFA13

Protein Function

NDUFS1 has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, contributes_to NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS1 itself. We selected most functions NDUFS1 had, and list some proteins which have the same functions with NDUFS1. You can find most of the proteins on our site.
Function
Related Protein
Function 2 iron, 2 sulfur cluster binding
Related Protein FXN; CISD2; AOX4; CISD1; AOX3L1; ISCA1; SDHB; ISCU; CMAH; XDH
Function 4 iron, 4 sulfur cluster binding
Related Protein ACO2; DDX11; NDUFS8B; NUBPL; NUBP1; LIAS; RSAD2; NDUFS8; ISCUB; POLD1
Function contributes_to NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFS4; NDUFS8; NDUFS1
Function NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFA2; NDUFS6; NDUFB6; NDUFA1; NDUFA12; NDUFS4; NDUFB10; NDUFA9; NDUFS1; NDUFA4
Function electron carrier activity
Related Protein AKR1C4; ACOX2; QDPR; GLRX5; NDUFA12; UGDH; AOX3L1; IVD; MAOB; FDX1
Function iron-sulfur cluster binding
Related Protein AIFM4; FXN; DPYDA.1; NUBP1; CMAH; DPYDB; NFS1; AOX4; RPS3; REV3L
Function metal ion binding
Related Protein PRIM1; Car12; ITGA6; ADO; Trl; BMPR1BA; ZBED5; SAR1B; ZBTB24; CAPN8
Function protein binding
Related Protein NDUFB9; ETS1; IGF1R; FOXP2; IGSF8; TOPORS; SNX20; ZFP932; ADAP1; ISYNA1

Interacting Protein

NDUFS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS1.
NDUFA2; HLA-B; NOA1; TNIP3; ECE2; C1QTNF9; 15-deoxy-delta(12,14; E2F3; NDUFS4; NDUFS5; NDUFS7; NDUFS6; NDUFS3; MYC; VCAM1; NDUFV2; Rab5c; Bmpr1a; HTT