NDUFS1
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Official Full Name
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -
Overview
The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NDUFS1;NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase);NADH dehydrogenase (ubiquinone) Fe S protein 1 (75kD) (NADH coenzyme Q reductase);NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial;CI 75k;complex I 75kDa subunit;NADH ubiquinone oxidoreductase 75 kDa subunit;mitochondrial;Complex I 75Kd;Complex I, mitochondrial respiratory chain, 75 kD subunit;NADH coenzyme Q reductase;NADH dehydrogenase (ubiquinone) FeS protein 1 (75kD) (NADH coenzyme Q reductase);NADH ubiquinone oxidoreductase 75 kDa subunit mitochondrial;PRO1304;complex I, mitochondrial respiratory chain, 75-kD subunit;mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit;CI-75k;CI-75Kd
Recombinant Proteins
- Mouse
- Chicken
- Zebrafish
- Human
- Rat
- Cynomolgus
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- T7
- Avi
- Fc
- DDK
- Myc
Involved Pathway
NDUFS1 involved in several pathways and played different roles in them. We selected most pathways NDUFS1 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | ATP6V1C2,ATP6V1H,NDUFS5,UQCR11,ATP4A,COX7B,COX5A,MT-ND1,ATP6V1E2,COX7A2L |
| Metabolic pathways | PAFAH1B3,NDUFA9A,AMY2A4,ACSL3B,B3GALNT1,MTMR7B,SPTLC2B,DAO,NANP,ATP6V1E2 |
| Parkinsons disease | NDUFS5,GNAL,VDAC2,MT-ATP6,NDUFS3,PRKACG,UQCRFS1,mt-Atp8,PARK2,NDUFB4 |
| Alzheimers disease | MME,LPL,UQCRFS1,NDUFS7,NDUFB4,NDUFA7,IDE,NDUFA2,SDHA,NDUFC2 |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFB11,SOCS3,NDUFAB1,NDUFB3,UQCR11,IL1A,SDHD,MAP3K11,IL-8,PIK3R5 |
| Huntingtons disease | COX4I1,DNAH5,GPX1,NRF1,HAP1,SDHD,UCP1,HDAC1,IFT57,NDUFS4 |
Protein Function
NDUFS1 has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding,4 iron, 4 sulfur cluster binding,contributes_to NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS1 itself. We selected most functions NDUFS1 had, and list some proteins which have the same functions with NDUFS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFA13,NDUFAB1,NDUFV3,NDUFA9,NDUFS4,NDUFB10,NDUFS5,NDUFA4,NDUFAF2,NDUFS6 |
| 2 iron, 2 sulfur cluster binding | FDX1,ISCU,AIFM3,CISD2,FDX1B,FXN,RFESD,AOX4,AOX3,SDHB |
| iron-sulfur cluster binding | ABAT,DPYDB,DPYDA.1,RTEL1,CMAH,EXO5,PRIM2,AIFM4,ELP3,AOX4 |
| contributes_to NADH dehydrogenase (ubiquinone) activity | NDUFS8,NDUFS4 |
| 4 iron, 4 sulfur cluster binding | TYW1,ISCA1,NUBP1,MOCS1,CDKAL1,EXO5,ACO2,ERCC2,NUBP2,MUTYH |
| metal ion binding | ZBTB16A,MMP30,RNF128A,PPP1CB,BNC2,PDP2,VPS29,FBXO30A,ADNP2B,XRCC6BP1 |
| protein binding | ALPL,BBS12,SLC25A18,EIF2B3,ROR2,FAM9A,TCEB1,ESYT2,E2F2,CNOT7 |
| electron carrier activity | FDX1L,GCDH,FDX1B,ACADVL,GCDHA,ACADM,ETFB,AIFM1,ME1,ACADS |
Interacting Protein
NDUFS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS1.
NDUFA2;HLA-B;NOA1;TNIP3;ECE2;C1QTNF9;15-deoxy-delta(12,14;E2F3;NDUFS4;NDUFS5;NDUFS7;NDUFS6;NDUFS3;MYC;VCAM1;NDUFV2;Rab5c;Bmpr1a;HTT
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