NDUFS1 Protein, NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)

NDUFS1

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NDUFS1

Official Full Name NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
Background The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 1 (75kD) (NADH coenzyme Q reductase); NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; CI 75k; complex I 75kDa subunit; NADH ubiquinone oxidoreductase 75 kDa subunit; mitochondrial; Complex I 75Kd; Complex I, mitochondrial respiratory chain, 75 kD subunit; NADH coenzyme Q reductase; NADH dehydrogenase (ubiquinone) FeS protein 1 (75kD) (NADH coenzyme Q reductase); NADH ubiquinone oxidoreductase 75 kDa subunit mitochondrial; PRO1304; complex I, mitochondrial respiratory chain, 75-kD subunit; mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit; CI-75k; CI-75Kd
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NDUFS1-1716H Recombinant Human NDUFS1 protein, His & T7-tagged E.coli His/T7
    Human NDUFS1-272H Recombinant Human NDUFS1 Mammalian Cell His
    Human NDUFS1-3898HCL Recombinant Human NDUFS1 293 Cell Lysate HEK293 N/A
    Mouse NDUFS1-10541M Recombinant Mouse NDUFS1 Protein Mammalian Cell His
    Rat NDUFS1-3942R Recombinant Rat NDUFS1 Protein Mammalian Cell His
    Cynomolgus Monkey NDUFS1-738C Recombinant Cynomolgus NDUFS1 Protein, His-tagged Mammalian Cell His
    Chicken NDUFS1-1656C Recombinant Chicken NDUFS1 Mammalian Cell His
    Zebrafish NDUFS1-1841Z Recombinant Zebrafish NDUFS1 Mammalian Cell His

    NDUFS1 involved in several pathways and played different roles in them. We selected most pathways NDUFS1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxidative phosphorylation NDUFB11; NDUFS1; UQCRC2A; Atp5g2; ATP5IA; mt-Atp8; NDUFA4; MT-ND1; ATP6V1E1; ATP6AP1
    Metabolic pathways PPAP2CB; UGP2; AGPAT4; CYP3A25; HYAL1; CHPF2; ASPA; ALDH3A2A; NDUFS2; PRODH2
    Non-alcoholic fatty liver disease (NAFLD) COX6A2; CEBPA; TNF; NDUFA6; INSR; IRS1; NDUFB5; PRKAA2; BAX; NDUFV2
    Alzheimers disease GRIN1; APAF1; APH1B; COX7A1; TNFRSF1A; NCSTN; CHP; UQCRQ; ATP5A1; MAPK1
    Parkinsons disease NDUFB5; CASP9; NDUFA4L2; SEPT5; ATP5G3; NDUFB4; NDUFC2; NDUFS2; NDUFAB1; NDUFA12
    Huntingtons disease COX7A2; COX7B; PLCB1; POLR2J3; POLR2J; NDUFS6; NDUFB3; COX7C; VDAC1; POLR2G

    NDUFS1 has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, contributes_to NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS1 itself. We selected most functions NDUFS1 had, and list some proteins which have the same functions with NDUFS1. You can find most of the proteins on our site.

    Function Related Protein
    2 iron, 2 sulfur cluster binding ISCA2; AIFM3; GLRX5; SDHB; AOX3; CIAPIN1; XDH; AIFM4; CMAH; AOX3L1
    4 iron, 4 sulfur cluster binding BRIP1; DNA2; ACO2; DEM1; RTEL1; ETFDH; ISCUB; NUBP1; POLA1; LIAS
    contributes_to NADH dehydrogenase (ubiquinone) activity NDUFS8; NDUFS4; NDUFS1
    NADH dehydrogenase (ubiquinone) activity NDUFB9; NDUFA2; NDUFS4; NDUFA3; NDUFAB1; NDUFV1; NDUFA8; NDUFV3; NDUFA7; NDUFS1
    electron carrier activity ACADL; COX7A3; SRD5A1; SDHD; ACADSB; DHRS3; CYP1A2; CYCSB; COX5A; GRXCR1
    iron-sulfur cluster binding AOX4; RTEL1; FXN; CISD3; DPYDB; ISCUB; PRIM2; ELP3; FDX1B; CMAH
    metal ion binding CYP2AD3; ZNF511; ZNF70; ADNP2; CYP3C1L2; TRIM43B; PITPNM1; RXRGB; DMRT3; STK24
    protein binding TTC8; GATA2; NOX5; TRIM37; TSSC4; NR0B2; TNNC2; BMPR1A; ZFPM2; SIP1

    NDUFS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS1.

    NDUFA2; HLA-B; NOA1; TNIP3; ECE2; C1QTNF9; 15-deoxy-delta(12,14; E2F3; NDUFS4; NDUFS5; NDUFS7; NDUFS6; NDUFS3; MYC; VCAM1; NDUFV2; Rab5c; Bmpr1a; HTT

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