ndufs2
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  • Official Full Name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
  • Background
  • The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 2 (49kD) (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; CI 49; complex I 49kDa subunit; NADH dehydrogenase [ubiquinone] iron sulfur protein 2; mitochondrial; CI 49kD; CI-49kD; Complex I 49kD; Complex I-49kD; NADH dehydrogenase [ubiquinone] iron sulfur protein 2, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2; NADH ubiquinone oxidoreductase 49 kDa subunit; NADH-ubiquinone oxidoreductase 49 kDa subunit; NDUS2_HUMAN; OTTHUMP00000032241; NADH-ubiquinone oxidoreductase NDUFS2 subunit; complex 1, mitochondrial res; CI-49
Cat.#:NDUFS2-2463HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human NDUFS2, His-tagged
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Cat.#:NDUFS2-30372THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NDUFS2
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Cat.#:NDUFS2-10542MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NDUFS2 Protein
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Cat.#:NDUFS2-3943RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NDUFS2 Protein
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Cat.#:NDUFS2-2988RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NDUFS2 Protein, His-tagged
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Cat.#:NDUFS2-2818ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NDUFS2
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Cat.#:NDUFS2-3897HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDUFS2 293 Cell Lysate
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Involved Pathway

NDUFS2 involved in several pathways and played different roles in them. We selected most pathways NDUFS2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
ATP6V0A2; ATP5A1; ATP6V1H; ATP6V0CA; NDUFA13; Atp5k; NDUFS1; ATP5L; NDUFC1; NDUFB10
Metabolic pathways
G6PC; HSD17B1; LIPG; AMPD2; TPO; CYP51A1; ADK; G6PC3; PYGL; MTMR7B
Non-alcoholic fatty liver disease (NAFLD)
NDUFV2; ADIPOR2; COX7A2; NDUFC2-KCTD14; COX7A1; COX7A2L; MAPK9; SDHD; NDUFAB1; INSR
Alzheimers disease
SDHA; PSEN2; NDUFB10; COX4I2; NDUFS2; NDUFA1; NDUFA2; BACE2; UQCRQ; APAF1
Parkinsons disease
ATP5E; SLC6A3; mt-Atp8; ATP5D; SLC18A2; SDHA; DRD1A; COX7A1; ATP5C1; CYCS
Huntingtons disease
TAF4B; NDUFA10; NDUFS8; CASP9; COX8A; ATP5D; NDUFS4; DNAH14; HTT; SDHA

Protein Function

NDUFS2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, NAD binding, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS2 itself. We selected most functions NDUFS2 had, and list some proteins which have the same functions with NDUFS2. You can find most of the proteins on our site.
Function
Related Protein
Function 4 iron, 4 sulfur cluster binding
Related Protein NDUFS7; RSAD2; DNA2; PPAT; ISCA1; CDKAL1; MUTYH; ETFDH; ISCA2; NDUFS8
Function NAD binding
Related Protein ME3; PHGDH; DLD; AOX3; NDUFS2; LDHA; CYB5R3; ADH4; HADHA; GRHPRA
Function NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFA7; NDUFB1; NDUFB10; NDUFC2-KCTD14; NDUFA4; NDUFV1; NDUFA1; NDUFA10; NDUFA3; NDUFB3
Function contributes_to NADH dehydrogenase activity
Related Protein NDUFS7; NDUFS2; NDUFV1; NDUFS8
Function electron carrier activity
Related Protein AOX4; NDUFV2; FDX1B; AKR1C4; ACAD11; GPX2; IVD; P4HA2; GLRX; ADH5
Function metal ion binding
Related Protein ZIC5; CYP8B2; TKTL2; S100T; GNA11; DAGLB; IMPDH1A; RYBPA; NUDT10; ZNF726
Function protein binding
Related Protein ID3; SEPT9; ISOC1; C2orf57; ARAF; USP19; EFNA1; KRT8; BLZF1; NINJ2
Function quinone binding
Related Protein NDUFS2; ABP1; HHIP; AOC1; TP53I3; ETFDH; SQRDL; AOC2; VKORC1L1; VKORC1
Function ubiquitin protein ligase binding
Related Protein CUL3B; MID1; HERC2; ACTG1; TPI1; UBE2G1; ANAPC2; POU5F1; DERL1; UBE2U

Interacting Protein

NDUFS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS2.
NDUFS3; NDUFA9; NDUFAF3; MYC; NDUFV2; NDUFA2; DMWD; SQSTM1; EGR2