ndufs4
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  • Official Full Name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
  • Background
  • This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes.
  • Synonyms
  • NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 4 (18kD) (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; AQDQ; CI 18
Cat.#:NDUFS4-2509HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NADH Dehydrogenase (ubiquinone) Fe-S Protein 4, 18kDa (NADH-coenzyme Q reductase)
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Cat.#:NDUFS4-367HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDUFS4
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Cat.#:NDUFS4-1240HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDUFS4, His-tagged
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Cat.#:NDUFS4-28208THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDUFS4
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Cat.#:NDUFS4-29482THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDUFS4
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Cat.#:NDUFS4-3944RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NDUFS4 Protein
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Cat.#:NDUFS4-2842ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NDUFS4
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Cat.#:NDUFS4-3895HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDUFS4 293 Cell Lysate
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Involved Pathway

NDUFS4 involved in several pathways and played different roles in them. We selected most pathways NDUFS4 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
ATP6V1G1; NDUFS7; UQCRC2B; NDUFS3; NDUFB8; COX8C; COX6B2; ATP6V0E1; UQCRH; COX7A1
Metabolic pathways
PTGES3B; NDUFB4; MPI; ST6GALNAC3; PNP5A; ACAD8; COX7B; OXSR1; COX6B1; OTC
Non-alcoholic fatty liver disease (NAFLD)
PIK3CG; SREBF1; IL1B; PIK3R5; PRKAB1; Il6ra; NDUFC1; PRKAG2; ITCH; IL6R
Alzheimers disease
ATP5B; RYR3; BID; CALM1; UQCR11; PPP3R1; CAPN1; LRP1; IL1B2; MT-ATP6
Parkinsons disease
SLC25A31; NDUFAB1; NDUFS7; UQCRFS1; NDUFC2-KCTD14; COX6B2; UBA1; UCHL1; SNCAIP; PPIF
Huntingtons disease
DCTN2; DCTN4; COX8A; BAX; NDUFS2; SDHB; POLR2C; NDUFV1; HAP1; NDUFB8

Protein Function

NDUFS4 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity, contributes_to NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS4 itself. We selected most functions NDUFS4 had, and list some proteins which have the same functions with NDUFS4. You can find most of the proteins on our site.
Function
Related Protein
Function NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFS4; NDUFB6; NDUFAB1; NDUFB2; NDUFB10; NDUFV1; NDUFA7; NDUFA2; NDUFA3; NDUFB5
Function contributes_to NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFS4; NDUFS1; NDUFS8

Interacting Protein

NDUFS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS4.
NDUFA2; UBE2G2; NDUFS8; COX7A2L; NDUFS5; NDUFS2; NDUFS3; NDUFB4; NDUFB8; NDUFA7; NDUFB10; MT-ND1; MT-ND4; MT-ND5; NDUFV2; NDUFS1; NDUFV1; NDUFV3