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Official Full Name NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
Background This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes.
Synonyms NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 4 (18kD) (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; AQDQ; CI 18
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NDUFS4-1240H Recombinant Human NDUFS4, His-tagged E.coli His
    Human NDUFS4-2509H Recombinant Human NADH Dehydrogenase (ubiquinone) Fe-S Protein 4, 18kDa (NADH-coenzyme Q reductase) E.coli N/A
    Human NDUFS4-28208TH Recombinant Human NDUFS4 E.coli N/A
    Human NDUFS4-29482TH Recombinant Human NDUFS4 E.coli N/A
    Human NDUFS4-367H Recombinant Human NDUFS4 E.coli N/A
    Human NDUFS4-3895HCL Recombinant Human NDUFS4 293 Cell Lysate HEK293 N/A
    Rat NDUFS4-3944R Recombinant Rat NDUFS4 Protein Mammalian Cell His
    Zebrafish NDUFS4-2842Z Recombinant Zebrafish NDUFS4 Mammalian Cell His

    NDUFS4 involved in several pathways and played different roles in them. We selected most pathways NDUFS4 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxidative phosphorylation ATP5S; NDUFB2; NDUFA4L; COX7A2A; NDUFB9; NDUFA9; PPA1; NDUFS7; LHPP; NDUFA10
    Metabolic pathways PFKMA; ST3GAL3; ALG1; POLA2; ACSS1; ALDH3B2; POLR3D; B4GALT7; BTD; NT5C1A
    Non-alcoholic fatty liver disease (NAFLD) MAP3K5; PIK3R2; PRKAB1; NDUFA8; UQCRH; NDUFB1; CDC42; ADIPOQ; NDUFA11; NDUFV1
    Alzheimers disease CYCS; NDUFB4; COX7A2L; PSEN2; ATP2A1; GRIN2A; MT-ATP6; ADAM10; NDUFS3; NDUFS4
    Parkinsons disease NDUFB4; PRKACG; NDUFV3; NDUFA11; PRKACB; mt-Atp8; UBE2G1; COX7B; COX7A2L; Casp3
    Huntingtons disease TBPL1; NDUFB1; VDAC3; HDAC2; POLR2A; NDUFA2; NDUFS5; SDHC; HIP1; ATP5G1

    NDUFS4 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity, contributes_to NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS4 itself. We selected most functions NDUFS4 had, and list some proteins which have the same functions with NDUFS4. You can find most of the proteins on our site.

    Function Related Protein
    NADH dehydrogenase (ubiquinone) activity NDUFB6; NDUFAB1; NDUFS6; NDUFS3; NDUFA10; NDUFA8; NDUFA13; NDUFA4; NDUFA5; NDUFB9
    contributes_to NADH dehydrogenase (ubiquinone) activity NDUFS1; NDUFS8; NDUFS4

    NDUFS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS4.


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