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NFX1

Official Full Name

nuclear transcription factor, X-box binding 1
Overview

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
Synonyms

NFX1; nuclear transcription factor, X-box binding 1; transcriptional repressor NF-X1; MGC20369; NFX2; NFX 1; Nuclear transcription factor X box binding 1; Nuclear transcription factor X box binding protein 1; Transcriptional repressor NF X1; OTTHUMP00000021213; OTTHUMP00000021214; OTTHUMP00000021215; nuclear transcription factor, X box-binding protein 1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NFX1-1284H	Recombinant Human NFX1, His-tagged	E.coli	His	771-1120aa	$319 / 25ug
Human	NFX1-3842HCL	Recombinant Human NFX1 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	Nfx1-1824M	Recombinant Mouse Nfx1 Protein, His-tagged	E.coli	N-His	His859-Asp1114	Inquiry

Involved Pathway
Protein Function
Interacting Protein

NFX1 involved in several pathways and played different roles in them. We selected most pathways NFX1 participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Binding and Uptake of Ligands by Scavenger Receptors	SPARC;HP;CD163;IGLC2;IGKV1-5;COL1A2;APOBB.1;COL1A1;HPX
Scavenging of heme from plasma	CD163;HPX;LOC479668;HP;NFX1;AMBP
Vesicle-mediated transport	BLOC1S3;MYO6A;GJB7;HYOU1;MIA3;COPZ1;PICALMA;SCFD1;PUM1

NFX1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by NFX1 itself. We selected most functions NFX1 had, and list some proteins which have the same functions with NFX1. You can find most of the proteins on our site.

Function	Related Protein

NFX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFX1.

UBE2N; UBE2D2; FAM46A