• Official Full Name
  • nuclear transcription factor, X-box binding 1
  • Background
  • MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
  • Synonyms
  • NFX1; nuclear transcription factor, X-box binding 1; transcriptional repressor NF-X1; MGC20369; NFX2; NFX 1; Nuclear transcription factor X box binding 1; Nuclear transcription factor X box binding protein 1; Transcriptional repressor NF X1; OTTHUMP00000021213; OTTHUMP00000021214; OTTHUMP00000021215; nuclear transcription factor, X box-binding protein 1
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFX1, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human NFX1 293 Cell Lysate

Involved Pathway

NFX1 involved in several pathways and played different roles in them. We selected most pathways NFX1 participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Binding and Uptake of Ligands by Scavenger Receptors
COL1A2; IGKC; SCGB3A2; IGKV1-5; SAA1; APOBB.1; NFX1; CD163; LOC479668; STAB2
Scavenging of heme from plasma
CD163; AMBP; HPX; LOC479668; HP; NFX1
Vesicle-mediated transport

Interacting Protein

NFX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFX1.