nkd2
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  • Official Full Name
  • naked cuticle homolog 2 (Drosophila)
  • Background
  • In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.
  • Synonyms
  • NKD2; naked cuticle homolog 2 (Drosophila); protein naked cuticle homolog 2; Dvl binding protein NKD2; naked cuticle 2; Naked2; hNkd2; Naked 2; naked-2; naked cuticle-2; OTTHUMP00000115406; OTTHUMP00000220490; Dvl-binding protein NKD2
Cat.#:NKD2-5888HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NKD2 Protein, GST-tagged
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Cat.#:NKD2-445HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NKD2 Protein, His-tagged
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Cat.#:NKD2-1198HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NKD2 cell lysate
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Involved Pathway

NKD2 involved in several pathways and played different roles in them. We selected most pathways NKD2 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKD2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
WNT2BB; SFRP2; AXIN1; WNT8A; PRICKLE2B; RHOAB; SMAD4; CXXC4; WIF1; CAMK2D2

Protein Function

NKD2 has several biochemical functions, for example, calcium ion binding, growth factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKD2 itself. We selected most functions NKD2 had, and list some proteins which have the same functions with NKD2. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein CDH5; MELK; TTN; PLSCR3; OVAL; PLSCR2; ABP1; CALB2; CDH23; EFCAB2
Function growth factor binding
Related Protein ACVR1C; IGFBP2A; HTRA1A; A2M; GHR; NRP1; LTBP4; TEK; KDR; NRP2
Function protein binding
Related Protein GDAP2; RAB41; SRPK2; CYTH1; PTGFRN; KLRC2; ING1; ZNF131; ARNT; FLT4
Function ubiquitin protein ligase binding
Related Protein GPR19; DTX1; GABARAP; PIAS2; TPI1; EIF4E2; FZD8; CCT2; YWHAZ; CDC34

Interacting Protein

NKD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKD2.
RCHY1; DVL1; TGFA; VDR; FUS; CDKN1A; GRB2; gltD1; ANAPC11; WWOX