nnt
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  • Official Full Name
  • nicotinamide nucleotide transhydrogenase
  • Background
  • This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene.
  • Synonyms
  • NNT; nicotinamide nucleotide transhydrogenase; NAD(P) transhydrogenase, mitochondrial; mitochondrial; MS701; NAD(P) transhydrogenase; NAD(P) transhydrogenase mitochondrial; NNTM; NNTM_HUMAN; Pyridine nucleotide transhydrogenase; OTTHUMP00000122432; OTTHUMP00000122433; OTTHUMP00000221608
Cat.#:NNT-5957HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NNT Protein, GST-tagged
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Cat.#:NNT-1321HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NNT, GST-tagged
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Cat.#:NNT-12777ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NNT
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Cat.#:NNT-3777HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NNT 293 Cell Lysate
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Cat.#:NNT-3778HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NNT 293 Cell Lysate
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Involved Pathway

NNT involved in several pathways and played different roles in them. We selected most pathways NNT participated on our site, such as Nicotinate and nicotinamide metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NNT were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Nicotinate and nicotinamide metabolism
AOX2P; NT5C3A; NT5C3L; NADKA; NT5C1AA; MIBP; BST1; AOX1; NMNAT1; CD38
Metabolic pathways
GART; DOLK; INPP5J; GLUD1A; CEPT1B; DPYDB; ATP6V0A1A; MUT; ACACA; ST3GAL1

Protein Function

NNT has several biochemical functions, for example, NAD binding, NAD(P)+ transhydrogenase (AB-specific) activity, NAD(P)+ transhydrogenase (B-specific) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NNT itself. We selected most functions NNT had, and list some proteins which have the same functions with NNT. You can find most of the proteins on our site.
Function
Related Protein
Function NAD binding
Related Protein GAPDH; HSD17B10; IDH1; SORD; IDH2; AOX3; HPGD; NDUFS2; HSD11B2; HADHA
Function NAD(P)+ transhydrogenase (AB-specific) activity
Related Protein NNT
Function NAD(P)+ transhydrogenase (B-specific) activity
Related Protein NNT
Function NAD(P)+ transhydrogenase activity
Related Protein DHDH; NNT
Function NADP binding
Related Protein NOS3; ASPDH; NOX5; FMO1; ME1; NOS2; DHFRL1; GAPDH; NDOR1; FMO5

Interacting Protein

NNT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NNT here. Most of them are supplied by our site. Hope this information will be useful for your research of NNT.
MVP; PAPD5; Wiz; Mkln1; MME; Junb; Papss1; HUWE1; ATL2; NEIL3; Cdc26; Mis12; SLAIN2