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NOS1

  • Official Full Name

    Nos1 nitric oxide synthase 1, neuronal

  • Overview

    The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from;L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including;neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric;oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke;and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This;protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that;differ in the 5 UTR have been described for this gene but the full-length nature of these transcripts is not known.Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been;found for this gene.
  • Synonyms

    NOS1; nitric oxide synthase 1, neuronal; nitric oxide synthase, brain; N-NOS; NC-NOS; NOS type I; neuronal NOS; constitutive NOS; neuronal nitric oxide synthase; peptidyl-cysteine S-nitrosylase NOS1; NO; bNOS; nNOS; NOS-I; Nos-1; 2310005C01Rik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NOS1-16H Active Recombinant Human NOS1 protein E.coli N/A
Human NOS1-612H Recombinant Human Nitric Oxide Synthase 1 (Neuronal) E.coli N/A
Human NOS1-7736H Recombinant Human NOS1 protein, His-tagged E.coli His Ile1199~Ile1399 (Accession # P29475)
Human NOS1-299H Recombinant Human NOS1 Mammalian Cell His
Human NOS1-3761HCL Recombinant Human NOS1 293 Cell Lysate HEK293 N/A
Human NOS1-2714H Recombinant Human NOS1 protein(231-310 aa), C-His-tagged E. coli C-His 231-310 aa
Human NOS1-5989H Recombinant Human NOS1 Protein, GST-tagged Wheat Germ GST
Human NOS1-1567HFL Recombinant Full Length Human NOS1 Protein, C-Flag-tagged Mammalian cells Flag
Human NOS1-4204H Recombinant Human NOS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NOS1-1524H Recombinant Human NOS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NOS1-1524H-B Recombinant Human NOS1 Protein Pre-coupled Magnetic Beads HEK293
Human NOS1-4715H Recombinant Human NOS1 Protein (Val1193-Asn1393), N-His tagged E.coli N-His Val1193-Asn1393
Mouse Nos1-7738M Recombinant Mouse Nos1 protein, His-tagged E.coli His Leu455~Asn601 (Accession # Q9Z0J4)
Mouse Nos1-7737M Recombinant Mouse Nos1 protein, His-tagged E.coli His Glu53~Pro247 (Accession # Q9Z0J4)
Mouse Nos1-7740M Recombinant Mouse Nos1 protein, His-tagged E.coli His Ser1213~Arg1337 (Accession # Q9Z0J4)
Mouse NOS1-10784M Recombinant Mouse NOS1 Protein Mammalian Cell His
Mouse Nos1-7739M Recombinant Mouse Nos1 protein, His-tagged E.coli His Phe691~Met826
Mouse NOS1-6135M-B Recombinant Mouse NOS1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Nos1-4460M Recombinant Mouse Nos1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NOS1-6135M Recombinant Mouse NOS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NOS1-4022R Recombinant Rat NOS1 Protein Mammalian Cell His
Rat Nos1-7742R Recombinant Rat Nos1 protein, His-tagged E.coli His Gly468~Leu616 (Accession # P29476)
Rat Nos1-7743R Recombinant Rat Nos1 protein, His-tagged E.coli His Arg726~Asp894 (Accession # P29476)
Rat Nos1-7741R Recombinant Rat Nos1 protein, His-tagged E.coli His Gln9~Ser136 (Accession # P29476)
Rat NOS1-3681R-B Recombinant Rat NOS1 Protein Pre-coupled Magnetic Beads HEK293
Rat NOS1-3681R Recombinant Rat NOS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish NOS1-9191Z Recombinant Zebrafish NOS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NOS1 Related Articles

NOS1 involved in several pathways and played different roles in them. We selected most pathways NOS1 participated on our site, such as Arginine biosynthesis, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arginine biosynthesisCPS1;NOS3;GLUD2;ASL;ACY1;OTC;ARG2;GOT2A;ybaS
Arginine and proline metabolismODC1;NOS3;SAT2B;DAO.3;ALDH7A1;CNDP1;ALDH2.2;DHDPSL;SAT1
Metabolic pathwaysIMPAD1;TYMP;THA1;ACOT5;GBGT1L4;PNP5A;CYP3A25;RABGNT1;CYP4A10
Calcium signaling pathwayGNAS;PTAFR;TACR3L;GNA14;ADRB2A;ERBB3B;GNA15.1;PLCD1;CACNA1D
PhagosomeCD209;DYNC1LI1;THBS1;RAB7;RAC1;MARCO;RAC1B;Ctsl;HLA-DRB5
Circadian entrainmentKCNJ9;CALM2;FOS;PRKCA;GNG12;CALM4;RYR2;RYR3;CAMK2D
Long-term depressionGNA13;ITPR1;PRKCA;GNAI2;PRKCG;CRHR1;MAP2K1;GNAZ;MAPK3
Salivary secretionPRH2;ATP1B2;CALM2;CST5;PRKCB;PRKCA;LYZ;PRKACA;VAMP2
Alzheimers diseaseBACE2;NDUFV1;PSEN2;NDUFS8;NDUFB7;CASP8;CALM3;ATF6;GAPDH
Amyotrophic lateral sclerosis (ALS)PPP3R2;DAXX;MAPK11;SLC1A2;MAPK13;BCL2;NOS1;TNFRSF1A;MAPK12

NOS1 has several biochemical functions, for example, FMN binding, NADP binding, NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NOS1 itself. We selected most functions NOS1 had, and list some proteins which have the same functions with NOS1. You can find most of the proteins on our site.

Function Related Protein
FMN bindingHAO2;NDOR1;CREG1;NOS2;POR;TYW1;CREG2;NOS1;HAO1
NADP bindingPOR;GAPDHS;GAPDH;NOX5;G6PD;ME1;GSR;CRYZL1;FMO1
NADPH-hemoprotein reductase activityMTRR;NDOR1;CYP2J6;NOS2A;NOS2B;POR;NOS3;NOS2;NOS1
arginine bindingRARS;NAGS;NOS1;NOS3;NOS2
cadmium ion bindingNOS1;P2RX2;SLC11A2;MT3;NOS3
calmodulin bindingMAPKAPK2;PPP3CA;RRAD;ADD3;PLA2G6;CNGA2;KCNN3;MARCKSB;MYO1D
enzyme bindingCALU;CAD;SCNM1;CYP2C8;PIAS1;CYP3A4;APBA3;CYB5A;XRCC1
flavin adenine dinucleotide bindingSDHA;LDHD;TXNRD3;AIFM3;CYBB;FMO1;ACOX1;ACADL;ACAD9
heme bindingCYP2Y3;CYP2X7;FECH;SDHD;CYP4F22;CYP2C50;CYP2C19;CYP26C1;CYBB
ion channel bindingFHL1;NEDD4L;KCNH5;LRRK2;CALM2;KCNIP2;KCNC1;EPN1;HSP90AB1
iron ion bindingACO2;HIF1AN;ALOX5;HBE1;EGLN3;CYP2N13;CYP4A10;ISCU;HBAA1
nitric-oxide synthase activityNOS1;NOS2;NOS2B;NOS3;NOS2A
protein bindingKIAA1191;LIN28B;PEBP1;PTTG1;SNW1;CCR3;ZNF490;MIIP;RGP1
protein homodimerization activityCIDEA;IRF3;RAB11FIP2;PPP2R4;VAPB;BMP2B;ADH1;SYNDIG1;PARK7
scaffold protein bindingNCK2;ATP2B4;CASP8;CACNA1G;SCN5A;NOS3;KRT5;CRIPT;TREM2
sodium channel regulator activityAGT;SCN1BB;SGK2;FXYD2;NOS1;FXYD4;FXYD7;GPLD1;PTPN3
tetrahydrobiopterin bindingTH;NOS1;NOS2;NOS3

NOS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOS1.

VAC14; Scn7a; Htr2b

Bergner, AJ; Stamp, LA; et al. Birthdating of Myenteric Neuron Subtypes in the Small Intestine of the Mouse. JOURNAL OF COMPARATIVE NEUROLOGY 522:514-527(2014).
Yoshimura, T; Moon, TC; et al. Expression of nitric oxide synthases in leukocytes in nasal polyps. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 108:172-U133(2012).
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