npffr2
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  • Official Full Name
  • neuropeptide FF receptor 2
  • Background
  • This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • NPFFR2; neuropeptide FF receptor 2; G protein coupled receptor 74 , GPR74; neuropeptide FF 2; NPFF2; NPGPR; G protein coupled receptor 74; G protein coupled receptor HLWAR 77; G protein coupled receptor HLWAR77; G-protein coupled receptor 74; G-protein coupled receptor HLWAR77; GPR 74; GPR74; HLWAR 77; HLWAR77; Neuropeptide G protein coupled receptor; Neuropeptide G-protein coupled receptor; NPFF 2; NPFF R2; NPFF2_HUMAN; NPFFR 2; G protein-coupled receptor 74
Cat.#:NPFFR2-6025HTag:N/A
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NPFFR2 Protein
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Cat.#:NPFFR2-1341HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NPFFR2, His-tagged
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Cat.#:NPFFR2-10818MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NPFFR2 Protein
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Cat.#:NPFFR2-4041RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NPFFR2 Protein
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Cat.#:NPFFR2-3283CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NPFFR2
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Cat.#:NPFFR2-1209HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human NPFFR2 cell lysate
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Involved Pathway

NPFFR2 involved in several pathways and played different roles in them. We selected most pathways NPFFR2 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPFFR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)
LPAR2A; GPR55; PROKR1; OXGR1A.1; CCL19A.2; CCL35.2; MLN; OPN4; SST; SSTR2
G alpha (q) signalling events
NPFF; APPB; FFAR3; EDN1; CCK; GPR17; GPR132B; RASGRP2; MLN; RGS18
GPCR downstream signaling
RAMP1; NET1; PROKR2; TAC1; RGS18; TAS2R16; GPR18; NPS; RGS10; SST1.1
GPCR ligand binding
ADRA2B; EDNRAB; GPR132B; UTS2D; AGT; NPS; TAC1; NPFFR2; SCT; ADORA3
GPCRs, Class A Rhodopsin-like
FPR-RS4; SSTR1; DRD4; CCBP2; GPR75; OPN1MW2; CCR1; GPR171; GPR1; OR10A5
Gastrin-CREB signalling pathway via PKC and MAPK
ABHD6B; NPFFR2; NMUR1; PROKR1; EDN1; DGKB; GPRC6A; NMS; QRFPR; OXTRL
Neuroactive ligand-receptor interaction
GABRR1; GNRHR; CHRM5A; PTGER2; NPY7R; TACR3; TAAR12F; P2RX3B; GRIA4; P2RX5
Orexin and neuropeptides FF and QRFP bind to their respective receptors
NPFFR2; NPFF; HCRT; QRFPR; QRFP

Protein Function

NPFFR2 has several biochemical functions, for example, G-protein coupled receptor activity, neuropeptide receptor activity, opioid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPFFR2 itself. We selected most functions NPFFR2 had, and list some proteins which have the same functions with NPFFR2. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor activity
Related Protein GPR146; MTNR1B; VMN1R46; VIPR1B; OLFR495; PRLHR2A; OPN1MW4; MRGPRB1; OLFCG4; GPR81
Function neuropeptide receptor activity
Related Protein KISS1RA; HCRTR1; NPBWR2; NPSR1; KISS1R; NPFFR2.1; NPFFR1L1; KISS1RB; MCHR1; NPFFR2
Function opioid receptor binding
Related Protein NPFFR2; NPFFR2.1
Function peptide binding
Related Protein CRIP1; PLOD1; GPR37; CLTB; NPFFR2.1; LTA4H; PCSK5; ANPEPA; CRHBP; GNRHR